Nitric Oxide-Producing Multiple Functional Nanoparticle Remodeling Tumor Microenvironment for Synergistic Photodynamic Immunotherapy against Hypoxic Tumor DOI
Shuyu Xu, Xinxin Xie, Ping He

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

The treatment of pancreatic cancer faces significant challenges due to connective tissue hyperplasia and severe hypoxia. Unlike oxygen-dependent Type II photosensitizers, I photosensitizers can produce a substantial amount reactive oxygen species, even under hypoxic conditions, making them more suitable for photodynamic therapy cancer. However, the dense extracellular matrix limits penetration efficiency presence immunosuppressive cells in tumor microenvironment reduces therapeutic effect. To address these challenges, we designed photoimmunotherapeutic M1@PAP nanoparticles composed photosensitizer anti-PD-L1 siRNA (siPD-L1), which was encapsulated into M1 macrophage membrane vesicles. In this system, pyropheophorbide-a (PPA) covalently conjugated poly-l-arginine (Arg9). Notably, it capable generating sufficient superoxide anions thereby functioning as photosensitizer. Furthermore, Arg9 acted nitric oxide (NO) donor, enhancing nanophotosensitizer by inhibiting cancer-associated fibroblast (CAF) activation decomposing matrix. Additionally, vesicles provided active targeting capabilities reeducated immunosuppressed M2 macrophages. reversal further promoted efficacy immunotherapy, showing great potential synergistic immunotherapy against tumor.

Language: Английский

Recent Advances in Nanomaterials-Based Targeted Drug Delivery for Preclinical Cancer Diagnosis and Therapeutics DOI Creative Commons
Harshita Tiwari, Nilesh Rai, Swati Singh

et al.

Bioengineering, Journal Year: 2023, Volume and Issue: 10(7), P. 760 - 760

Published: June 25, 2023

Nano-oncology is a branch of biomedical research and engineering that focuses on using nanotechnology in cancer diagnosis treatment. Nanomaterials are extensively employed the field oncology because their minute size ultra-specificity. A wide range nanocarriers, such as dendrimers, micelles, PEGylated liposomes, polymeric nanoparticles used to facilitate efficient transport anti-cancer drugs at target tumor site. Real-time labeling monitoring cells quantum dots essential for determining level therapy needed The drug targeted site either by passive or active means. Passive targeting makes use microenvironment enhanced permeability retention effect, while involves ligand-coated nanoparticles. Nanotechnology being diagnose early stage detecting cancer-specific biomarkers imaging. implication employs photoinduced nanosensitizers, reverse multidrug resistance, enabling delivery CRISPR/Cas9 RNA molecules therapeutic applications. However, despite recent advancements nano-oncology, there need delve deeper into domain designing applying improved diagnostics.

Language: Английский

Citations

74
Oxygen-independent organic photosensitizer with ultralow-power NIR photoexcitation for tumor-specific photodynamic therapy DOI Creative Commons
Yufu Tang, Yuanyuan Li, Bowen Li

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: March 21, 2024

Abstract Photodynamic therapy (PDT) is a promising cancer treatment but has limitations due to its dependence on oxygen and high-power-density photoexcitation. Here, we report polymer-based organic photosensitizers (PSs) through rational PS skeleton design precise side-chain engineering generate •O 2 − •OH under oxygen-free conditions using ultralow-power 808 nm photoexcitation for tumor-specific photodynamic ablation. The designed skeletons can electron-hole pairs sensitize H O into with photoexcitation, achieving NIR-photoexcited oxygen-independent production. Further, compared commonly used alkyl side chains, glycol oligomer as the chain mitigates recombination offers more molecules around generated from hydrophobic skeletons, which yield 4-fold stronger production, thus allowing an high PDT effect. Finally, feasibility of developing activatable PSs in female mice further demonstrated irradiation 15 mW cm −2 . study not only provides insights mechanism also general guideline develop NIR PDT.

Language: Английский

Citations

69
Recent advances in type I organic photosensitizers for efficient photodynamic therapy for overcoming tumor hypoxia DOI
Bingli Lu, Lingyun Wang, Hao Tang

et al.

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(21), P. 4600 - 4618

Published: Jan. 1, 2023

Photodynamic therapy (PDT) with an oxygen-dependent character is a noninvasive therapeutic method for cancer treatment.

Language: Английский

Citations

63
Photo‐Induced Disproportionation‐Mediated Photodynamic Therapy: Simultaneous Oxidation of Tetrahydrobiopterin and Generation of Superoxide Radicals DOI
Kun‐Xu Teng, Dongsheng Zhang,

Bin‐Kai Liu

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(12)

Published: Jan. 23, 2024

We herein present an approach of photo-induced disproportionation for preparation Type-I photodynamic agents. As a proof concept, BODIPY-based photosensitizers were rationally designed and prepared. The intermolecular electron transfer between homotypic chromophores leads to the reaction, resulting in formation charged intermediates, cationic anionic radicals. radicals efficiently oxidize cellularimportant coenzyme, tetrahydrobiopterin (BH

Language: Английский

Citations

45
Supramolecular systems for bioapplications: recent research progress in China DOI
Yue‐Yang Liu, Xiao-Yong Yu, Yu‐Chen Pan

et al.

Science China Chemistry, Journal Year: 2024, Volume and Issue: 67(5), P. 1397 - 1441

Published: March 22, 2024

Language: Английский

Citations

31
Deciphering Oxygen‐Independent Augmented Photodynamic Oncotherapy by Facilitating the Separation of Electron‐Hole Pairs DOI
Xiaoming Hu, Zhu-ting Fang,

Fengwei Sun

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(15)

Published: Feb. 16, 2024

Developing Type-I photosensitizers provides an attractive approach to solve the dilemma of inadequate efficacy photodynamic therapy (PDT) caused by inherent oxygen consumption traditional Type-II PDT and anoxic tumor microenvironment. The challenge for exploration PSs is facilitate electron transfer ability photosensitization molecules transforming or H

Language: Английский

Citations

23
Thymoquinone as an electron transfer mediator to convert Type II photosensitizers to Type I photosensitizers DOI Creative Commons
Jiahao Zhuang, Guobin Qi,

Yecheng Feng

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: June 10, 2024

Abstract The development of Type I photosensitizers (PSs) is great importance due to the inherent hypoxic intolerance photodynamic therapy (PDT) in microenvironment. Compared II PSs, PSs are less reported absence a general molecular design strategy. Herein, we report that combination typical PS and natural substrate carvacrol (CA) can significantly facilitate pathway efficiently generate superoxide radical (O 2 –• ). Detailed mechanism study suggests CA activated into thymoquinone (TQ) by local singlet oxygen generated from upon light irradiation. With TQ as an efficient electron transfer mediator, it promotes conversion O via transfer-based pathway. Notably, three classical employed demonstrate universality proposed approach. PDT against S. aureus has been demonstrated under conditions vitro. Furthermore, this coupled agent exhibits significant bactericidal activity with antibacterial rate 99.6% for bacterial-infection female mice vivo experiments. Here, show simple, effective, universal method endow traditional tolerance.

Language: Английский

Citations

21
pH/GSH dual responsive nanosystem for nitric oxide generation enhanced type I photodynamic therapy DOI Creative Commons
Jianhua Zou, Zheng Li, Yang Zhu

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 34, P. 414 - 421

Published: Jan. 10, 2024

Tumor hypoxia diminishes the effectiveness of traditional type II photodynamic therapy (PDT) due to oxygen consumption. Type I PDT, which can operate independently oxygen, is a viable option for treating hypoxic tumors. In this study, we have designed and synthesized JSK@PEG-IR820 NPs that are responsive tumor microenvironment (TME) enhance PDT through glutathione (GSH) depletion. Our approach aims expand sources therapeutic benefits by promoting generation superoxide radicals (O

Language: Английский

Citations

20
Pyroptosis of Breast Cancer Stem Cells and Immune Activation Enabled by a Multifunctional Prodrug Photosensitizer DOI
Yuqi Tang, Zhichao Wang, Quan Li

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(37)

Published: April 23, 2024

Abstract Breast cancer stem cells (CSCs) are responsible for the occurrence, resistance, recurrence, invasion, and metastasis of tumors. However, even trace amounts CSCs may lead to tumor resistance which fundamentally reduces therapeutic efficiency numerous anticancer drugs. Thus, development a agent that can reduce tumorigenicity overcome recurrence is essential. Here novel multifunctional prodrug T‐P reported as photosensitizer, links phenothiazine drug with synthesized aggregation‐induced emission photosensitizer T‐C via an ester bond. Importantly, this found be able induce pyroptosis breast well activate their death pathway protein phosphatase 2A inhibit systemic anti‐tumor effects. rapidly target mitochondria overlap lysosomes after mitochondrial escape, it cause lysosomal dysfunction. It releases reactive oxygen species through photoactivation, triggering pyroptosis‐mediated strong immune response. On 5th day in vivo therapy cancer, primary eliminated growth distant tumors also inhibited. This research would provide impetus new strategy CSCs‐targeted photoimmunotherapy beyond.

Language: Английский

Citations

19
Heterodimeric Photosensitizer as Radical Generators to Promoting Type I Photodynamic Conversion for Hypoxic Tumor Therapy DOI Open Access
Tao Xiong, Yingchao Chen, Qiang Peng

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 26, 2025

Abstract Photodynamic therapy (PDT) using traditional type II photosensitizers (PSs) has been limited in hypoxic tumors due to excessive oxygen consumption. The conversion from into a less oxygen‐dependent I PDT pathway shown the potential combat tumors. Herein, design of heterodimeric PS, NBSSe , by conjugating widely used PS NBS and NBSe via molecular dimerization, achieving aggregation‐regulated efficient photodynamic for first time is reported. Electrochemistry characterizations theoretical calculations elucidate that tends form S +· /Se −· radical pair intramolecular electron transfer co‐excited * aggregate, realizing 7.25‐fold O 2 generation compared 80% suppression 1 . enhanced enables excellent anti‐hypoxia efficiency inhibition pulmonary metastasis. Additionally, incorporation electron‐rich bovine serum albumin accelerates recycling cationic further boosting photostability generation. resultant BSA@NBSSe nanoparticles demonstrate successful tumor‐targeting capability. This work provides an appealing avenue convert ROS cancer phototherapy hypoxia.

Language: Английский

Citations

3