Chinese Journal of Chemistry,
Год журнала:
2024,
Номер
42(13), С. 1447 - 1455
Опубликована: Март 13, 2024
Comprehensive
Summary
Sugar
moieties
present
on
bacterial
surface
serve
as
pivotal
regulators
of
activity.
Precisely
adjusting
the
abundance
and
distribution
sugar
can
offer
an
important
approach
to
manipulating
behavior,
but
has
been
proven
be
difficult.
Herein,
topological
glycosylation
is
reported
mediate
interaction
bacteria
with
mucous
layer.
Alkynes
functionalized
by
different
branching
are
synthesized
through
iterative
Michael
addition
amide
condensation
reactions.
By
a
copper‐catalyzed
azide‐alkyne
cycloaddition,
resulting
compounds
structures
attached
onto
that
modified
azido
groups.
As
proof‐of‐concept
study,
set
topologically
glycosylated
probiotics
(TGPs)
prepared
using
linear,
two‐branched,
tetra‐branched
compounds,
respectively.
The
between
mucin
TGPs
was
studied
results
demonstrate
that,
compared
unmodified
bacteria,
exhibit
enhanced
adhesive
capacity
mucin,
which
increases
numbers.
Similar
binding
trend
observed
in
ex
vivo
colonic
mucus
adhesion
experiments
display
highest
efficiency.
This
work
proposes
chemical
method
tune
providing
unique
significant
insights
into
manipulation
behavior
modification.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 6, 2024
Abstract
Ferroptosis
nano‐inducers
have
drawn
considerable
attention
in
the
treatment
of
malignant
tumors.
However,
low
intratumoral
hydrogen
peroxide
level
and
complex
biological
barriers
hinder
ability
nanomedicines
to
generate
sufficient
reactive
oxygen
species
(ROS)
achieve
tumor
penetration.
Here
a
near‐infrared
(NIR)‐driven
ROS
self‐supplying
nanomotor
is
successfully
designed
for
synergistic
chemodynamic
therapy
(CDT)
photothermal
(PTT).
Janus
created
by
asymmetrical
modification
polydopamine
(PDA)
with
zinc
(ZnO
2
)
subsequent
ferrous
ion
(Fe
2+
chelation
via
polyphenol
groups
from
PDA,
here
refer
as
ZnO
@PDA‐Fe
(Z@P‐F).
capable
slowly
releasing
(H
O
into
an
acidic
microenvironment
(TME)
providing
ingredients
Fenton
reaction
necessary
ferroptosis.
Upon
NIR
laser
irradiation,
loaded
Fe
released
thermal
gradient
simultaneously
formed
owing
asymmetric
PDA
coating,
thus
endowing
self‐thermophoresis
based
enhanced
diffusion
lysosomal
escape
Therefore,
release
ions
),
self‐supplied
H
,
nanomotors
actuation
further
improve
CDT/PTT
efficacy,
showing
great
potential
active
therapy.
Advanced Materials,
Год журнала:
2024,
Номер
36(26)
Опубликована: Март 16, 2024
A
low-generation
lysine
dendrimer,
SPr-G2,
responds
to
intracellular
glutathione
initiate
bioorthogonal
in
situ
polymerization,
resulting
the
formation
of
large
assemblies
mouse
breast
cancer
cells.
The
SPr-G2
can
interact
with
lysosomes
induce
lysosome
expansion
and
enhance
lysosomal
membrane
permeabilization,
leading
major
histocompatibility
complex
class
I
upregulation
on
tumor
cell
surfaces
ultimately
death.
Moreover,
use
dendrimer
conjugate
chemotherapeutic
drug,
camptothecin
(CPT),
boost
therapeutic
potency
CPT.
Excellent
antitumor
effects
vitro
vivo
are
obtained
from
combinational
treatment
This
effect
also
enhances
immunity
through
promoting
activation
cytotoxic
T
cells
tissues
maturation
dendritic
study
shed
new
light
development
peptide
agents
for
therapy.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
63(2)
Опубликована: Ноя. 29, 2023
Abstract
Dendritic
cell
vaccine
(DCV)
holds
great
potential
in
tumor
immunotherapy
owing
to
its
potent
ability
eliciting
tumor‐specific
immune
responses.
Aiming
at
engineering
enhanced
DCV,
we
report
the
first
effort
construct
a
glycopolymer‐engineered
DC
(G‐DCV)
via
metabolicglycoengineering
and
copper‐free
click‐chemistry.
Model
G‐DCV
was
prepared
by
firstly
delivering
antigens,
ovalbumin
(OVA)
into
dendritic
cells
(DC)
with
fluoroalkane‐grafted
polyethyleneimines,
followed
conjugating
glycopolymers
terminal
group
of
dibenzocyclooctyne
(DBCO)
onto
cells.
Compared
unmodified
our
could
induce
stronger
T
activation
due
adhesion
between
DCs
Notably,
such
more
effectively
inhibit
growth
mouse
B16‐OVA
(expressing
OVA
antigen)
model
after
adoptive
transfer.
Moreover,
combination
an
checkpoint
inhibitor,
showed
further
increased
anti‐tumor
effects
treating
different
models.
Thus,
work
provides
novel
strategy
enhance
therapeutic
effectiveness
vaccines.
Advanced Materials,
Год журнала:
2024,
Номер
36(25)
Опубликована: Апрель 2, 2024
Due
to
inherent
differences
in
cellular
composition
and
metabolic
behavior
with
host
cells,
tumor-harbored
bacteria
can
discriminatorily
affect
tumor
immune
landscape.
However,
the
mechanisms
by
which
intracellular
antigen
presentation
process
between
cells
antigen-presenting
(APCs)
are
largely
unknown.
The
invasion
of
attenuated
Salmonella
VNP20009
(VNP)
into
is
investigated
an
attempt
made
modulate
this
modifying
positively
charged
polymers
on
surface
VNP.
It
found
that
non-toxic
chitosan
oligosaccharide
(COS)
modified
VNP
(VNP@COS)
bolsters
formation
gap
junction
APCs
enhancing
ability
infect
cells.
On
basis,
a
bacterial
biohybrid
designed
promote
situ
cross-presentation
through
induced
junction.
This
also
enhances
expression
major
histocompatibility
complex
class
I
molecules
incorporation
Mdivi-1
coupled
VNP@COS.
strategic
integration
serves
heighten
immunogenic
exposure
antigens;
while,
preserving
cytotoxic
potency
T
A
strategy
proposed
precisely
controlling
function
local
effects
microorganisms
within
tumors.
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 26, 2024
Engineered
bacteria-mediated
antitumor
approaches
have
been
proposed
as
promising
immunotherapies
for
cancer.
However,
the
off-target
bacterial
toxicity
narrows
therapeutic
window.
Living
microbes
will
benefit
from
their
controllable
immunogenicity
within
tumors
safer
applications.
In
this
study,
a
genetically
encoded
microbial
activation
strategy
is
reported
that
uses
tunable
and
dynamic
expression
of
surface
extracellular
polysaccharides
to
improve
biocompatibility
while
retaining
efficacy.
Based
on
screening
genes
associated
with
Salmonella
survival
in
macrophages,
novel
attenuated
chassis
strain
AIS
(htrA
gene-deficient)
highly
enriched
after
administration
rapidly
cleared
normal
organs
are
reported.
Subsequently,
an
engineered
strain,
AISI-H,
constructed
based
optimized
quorum-sensing
regulatory
system.
The
AISI-H
can
achieve
recovery
tumor-specific
virulence
through
HTRA-RCSA
axis-based
synthetic
gene
circuit-mediated
increase
polysaccharide
content.
These
strains
act
"off"
avoid
unwanted
immune
"on"
precise
tumor
suppression
mice.
shows
significant
inhibition
potent
anticancer
immunity
melanoma
mouse
model.
exhibits
excellent
biocompatibility.
This
regulation
expands
applications
microbe-based
therapeutics.
ACS Nano,
Год журнала:
2024,
Номер
18(47), С. 32517 - 32533
Опубликована: Ноя. 11, 2024
Due
to
the
uncertain
differentiation
of
neural
stem
cells
(NSCs),
replenishing
lost
neurons
by
endogenous
repair
spinal
cord
injury
(SCI)
remains
challenging.
The
electrical
stimulation-induced
drug
release
is
a
promising
approach
for
localized
and
controlled
drugs
regulate
NSCs
into
neurons.
Here,
we
developed
Zn-PDA@BT
nanoparticles
acted
as
Trojan
Horse
enter
through
endocytosis
Zn
