Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 1, 2024
Abstract
Within
living
organisms,
numerous
nanomachines
are
constantly
involved
in
complex
polymerization
processes,
generating
a
diverse
array
of
biomacromolecules
for
maintaining
biological
activities.
Transporting
artificial
polymerizations
from
lab
settings
into
contexts
has
expanded
opportunities
understanding
and
managing
events,
creating
novel
cellular
compartments,
introducing
new
functionalities.
This
review
summarizes
the
recent
advancements
polymerizations,
including
those
responding
to
external
stimuli,
internal
environmental
factors,
that
polymerize
spontaneously.
More
importantly,
cutting‐edge
biomedical
application
scenarios
polymerization,
notably
safeguarding
cells,
modulating
improving
diagnostic
performance,
facilitating
therapeutic
efficacy
highlighted.
Finally,
this
outlines
key
challenges
technological
obstacles
remain
as
well
offers
insights
potential
directions
advancing
their
practical
applications
clinical
trials.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 6, 2024
Abstract
Ferroptosis
nano‐inducers
have
drawn
considerable
attention
in
the
treatment
of
malignant
tumors.
However,
low
intratumoral
hydrogen
peroxide
level
and
complex
biological
barriers
hinder
ability
nanomedicines
to
generate
sufficient
reactive
oxygen
species
(ROS)
achieve
tumor
penetration.
Here
a
near‐infrared
(NIR)‐driven
ROS
self‐supplying
nanomotor
is
successfully
designed
for
synergistic
chemodynamic
therapy
(CDT)
photothermal
(PTT).
Janus
created
by
asymmetrical
modification
polydopamine
(PDA)
with
zinc
(ZnO
2
)
subsequent
ferrous
ion
(Fe
2+
chelation
via
polyphenol
groups
from
PDA,
here
refer
as
ZnO
@PDA‐Fe
(Z@P‐F).
capable
slowly
releasing
(H
O
into
an
acidic
microenvironment
(TME)
providing
ingredients
Fenton
reaction
necessary
ferroptosis.
Upon
NIR
laser
irradiation,
loaded
Fe
released
thermal
gradient
simultaneously
formed
owing
asymmetric
PDA
coating,
thus
endowing
self‐thermophoresis
based
enhanced
diffusion
lysosomal
escape
Therefore,
release
ions
),
self‐supplied
H
,
nanomotors
actuation
further
improve
CDT/PTT
efficacy,
showing
great
potential
active
therapy.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(26)
Published: March 16, 2024
A
low-generation
lysine
dendrimer,
SPr-G2,
responds
to
intracellular
glutathione
initiate
bioorthogonal
in
situ
polymerization,
resulting
the
formation
of
large
assemblies
mouse
breast
cancer
cells.
The
SPr-G2
can
interact
with
lysosomes
induce
lysosome
expansion
and
enhance
lysosomal
membrane
permeabilization,
leading
major
histocompatibility
complex
class
I
upregulation
on
tumor
cell
surfaces
ultimately
death.
Moreover,
use
dendrimer
conjugate
chemotherapeutic
drug,
camptothecin
(CPT),
boost
therapeutic
potency
CPT.
Excellent
antitumor
effects
vitro
vivo
are
obtained
from
combinational
treatment
This
effect
also
enhances
immunity
through
promoting
activation
cytotoxic
T
cells
tissues
maturation
dendritic
study
shed
new
light
development
peptide
agents
for
therapy.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(25)
Published: April 2, 2024
Due
to
inherent
differences
in
cellular
composition
and
metabolic
behavior
with
host
cells,
tumor-harbored
bacteria
can
discriminatorily
affect
tumor
immune
landscape.
However,
the
mechanisms
by
which
intracellular
antigen
presentation
process
between
cells
antigen-presenting
(APCs)
are
largely
unknown.
The
invasion
of
attenuated
Salmonella
VNP20009
(VNP)
into
is
investigated
an
attempt
made
modulate
this
modifying
positively
charged
polymers
on
surface
VNP.
It
found
that
non-toxic
chitosan
oligosaccharide
(COS)
modified
VNP
(VNP@COS)
bolsters
formation
gap
junction
APCs
enhancing
ability
infect
cells.
On
basis,
a
bacterial
biohybrid
designed
promote
situ
cross-presentation
through
induced
junction.
This
also
enhances
expression
major
histocompatibility
complex
class
I
molecules
incorporation
Mdivi-1
coupled
VNP@COS.
strategic
integration
serves
heighten
immunogenic
exposure
antigens;
while,
preserving
cytotoxic
potency
T
A
strategy
proposed
precisely
controlling
function
local
effects
microorganisms
within
tumors.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
63(2)
Published: Nov. 29, 2023
Abstract
Dendritic
cell
vaccine
(DCV)
holds
great
potential
in
tumor
immunotherapy
owing
to
its
potent
ability
eliciting
tumor‐specific
immune
responses.
Aiming
at
engineering
enhanced
DCV,
we
report
the
first
effort
construct
a
glycopolymer‐engineered
DC
(G‐DCV)
via
metabolicglycoengineering
and
copper‐free
click‐chemistry.
Model
G‐DCV
was
prepared
by
firstly
delivering
antigens,
ovalbumin
(OVA)
into
dendritic
cells
(DC)
with
fluoroalkane‐grafted
polyethyleneimines,
followed
conjugating
glycopolymers
terminal
group
of
dibenzocyclooctyne
(DBCO)
onto
cells.
Compared
unmodified
our
could
induce
stronger
T
activation
due
adhesion
between
DCs
Notably,
such
more
effectively
inhibit
growth
mouse
B16‐OVA
(expressing
OVA
antigen)
model
after
adoptive
transfer.
Moreover,
combination
an
checkpoint
inhibitor,
showed
further
increased
anti‐tumor
effects
treating
different
models.
Thus,
work
provides
novel
strategy
enhance
therapeutic
effectiveness
vaccines.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 26, 2024
Engineered
bacteria-mediated
antitumor
approaches
have
been
proposed
as
promising
immunotherapies
for
cancer.
However,
the
off-target
bacterial
toxicity
narrows
therapeutic
window.
Living
microbes
will
benefit
from
their
controllable
immunogenicity
within
tumors
safer
applications.
In
this
study,
a
genetically
encoded
microbial
activation
strategy
is
reported
that
uses
tunable
and
dynamic
expression
of
surface
extracellular
polysaccharides
to
improve
biocompatibility
while
retaining
efficacy.
Based
on
screening
genes
associated
with
Salmonella
survival
in
macrophages,
novel
attenuated
chassis
strain
AIS
(htrA
gene-deficient)
highly
enriched
after
administration
rapidly
cleared
normal
organs
are
reported.
Subsequently,
an
engineered
strain,
AISI-H,
constructed
based
optimized
quorum-sensing
regulatory
system.
The
AISI-H
can
achieve
recovery
tumor-specific
virulence
through
HTRA-RCSA
axis-based
synthetic
gene
circuit-mediated
increase
polysaccharide
content.
These
strains
act
"off"
avoid
unwanted
immune
"on"
precise
tumor
suppression
mice.
shows
significant
inhibition
potent
anticancer
immunity
melanoma
mouse
model.
exhibits
excellent
biocompatibility.
This
regulation
expands
applications
microbe-based
therapeutics.
Chemical Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Cell-interface
engineering
is
a
way
to
functionalize
cells
through
direct
or
indirect
self-assembly
of
functional
materials
around
the
cells,
showing
an
enhancement
cell
functions.
Among
used
in
cell-interface
engineering,
natural
biomolecules
play
pivotal
roles
study
biological
interfaces,
given
that
they
have
good
advantages
such
as
biocompatibility
and
rich
groups.
In
this
review,
we
summarize
overview
development
studies
been
cell-biointerface
then
review
five
main
types
constructing
biointerfaces,
namely
DNA
polymers,
amino
acids,
polyphenols,
proteins
polysaccharides,
show
their
applications
green
energy,
biocatalysis,
therapy
environmental
protection
remediation.
Lastly,
current
prospects
challenges
area
are
presented
with
potential
solutions
solve
these
problems,
which
turn
benefits
design
next-generation
engineering.
