Chemical Society Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Intracellular
metal
ions
play
essential
roles
in
multiple
physiological
processes,
including
catalytic
action,
diverse
cellular
intracellular
signaling,
and
electron
transfer.
It
is
crucial
to
maintain
ion
homeostasis
which
achieved
by
the
subtle
balance
of
storage
release
intracellularly
along
with
influx
efflux
at
interface
cell
membrane.
Dysregulation
has
been
identified
as
a
key
mechanism
triggering
programmed
death
(PCD).
Despite
importance
initiating
PCD,
molecular
mechanisms
within
these
processes
are
infrequently
discussed.
An
in-depth
understanding
review
role
PCD
may
better
uncover
novel
tools
for
cancer
diagnosis
therapy.
Specifically,
calcium
(Ca
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(29)
Опубликована: Фев. 23, 2024
Abstract
Autophagy,
a
lysosome‐involved
degradation
pathway,
as
self‐protective
cellular
process,
always
weakens
the
efficiency
of
tumor
therapies.
Herein,
for
first
time,
biodegradable
copper
(Cu)
ions
doped
layered
double
hydroxide
(Cu‐LDH)
nanoparticles
are
reported
cancer
immunotherapy
via
lysosomal
rupture‐mediated
“Broken
Window
Effect”.
Only
injection
Cu‐LDH
single
therapeutic
agent
achieves
various
organelles
destruction
after
rupture,
well
abnormal
aggregation
Cu
in
cells
cuproptosis
and
pyroptosis.
More
importantly,
autophagy
inhibition
caused
by
rupture
improves
overload‐mediated
pyroptosis
blocking
lysosome‐mediated
bulk
leading
to
good
anti‐tumor
immune
responses
ultimately
high‐efficiency
growth
inhibition.
This
Effect”
provides
new
paradigm
enhanced
therapy.
Advanced Materials,
Год журнала:
2024,
Номер
36(45)
Опубликована: Сен. 17, 2024
Abstract
The
overexpression
of
polyamines
in
tumor
cells
contributes
to
the
establishment
immunosuppressive
microenvironment
and
facilitates
growth.
Here,
it
have
ingeniously
designed
multifunctional
copper‐piceatannol/HA
nanopills
(Cu‐Pic/HA
NPs)
that
effectively
cause
total
intracellular
depletion
by
inhibiting
synthesis,
depleting
polyamines,
impairing
uptake,
resulting
enhanced
pyroptosis
cuproptosis,
thus
activating
a
powerful
immune
response
achieve
anti‐tumor
therapy.
Mitochondrial
dysfunction
from
overall
not
only
leads
surge
copper
ions
mitochondria,
thereby
causing
aggregation
toxic
proteins
induce
but
also
triggers
accumulation
reactive
oxygen
species
(ROS)
within
which
further
upregulates
expression
zDHHC5
zDHHC9
promote
palmitoylation
gasdermin
D
(GSDMD)
GSDMD‐N,
ultimately
inducing
pyroptosis.
Then
occurrence
cuproptosis
is
conductive
remodel
microenvironment,
responses
growth
metastasis.
This
therapeutic
strategy
through
comprehensive
provides
novel
template
for
cancer
immunotherapy.
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 2, 2025
Despite
the
promising
clinical
applications
of
immunotherapy,
its
effectiveness
is
often
limited
by
low
immune
responses
and
tumor
escape.
In
this
study,
we
introduce
a
simple
drug-free
inorganic
nanomaterial,
sodium
succinate
(C4H4Na2O4
NPs),
prepared
using
rapid
microemulsion
method
to
enhance
cancer
immunotherapy.
The
synthesized
C4H4Na2O4
NPs
can
release
high
concentrations
Na+
ions
into
cells,
leading
an
increase
in
intracellular
osmolarity.
This
triggers
pyroptosis
pathway,
resulting
cellular
contents,
inflammatory
factors,
damage-associated
molecular
patterns,
which
ultimately
boost
responses.
Furthermore,
inhibit
escape
through
upregulating
major
histocompatibility
complex-I
(MHC-I)
expression.
Collectively,
significantly
growth
metastasis
pyroptosis-induced
activation
MHC-I
expression
upregulation-remitted
research
offers
novel
approach
treatment
that
leverages
pyroptosis,
demonstrating
potential
for
application
Advanced Materials,
Год журнала:
2023,
Номер
36(14)
Опубликована: Дек. 28, 2023
Pyroptosis
has
garnered
increasing
attention
in
cancer
immunotherapy.
Moreover,
plasma
membrane
damage
by
reactive
oxygen
species
(ROS)
is
considered
an
effective
strategy
for
promoting
pyroptosis.
However,
the
current
tactics
enhancing
rupture
pyroptosis
are
limited
inherent
drawbacks
of
ROS
and
immunosuppressive
tumor
microenvironment.
Herein,
a
self-adaptive
inducer
(LPZ)
designed
integrating
Lactobacillus
rhamnosus
GG
(LGG)
enzyme-like
metal-organic
framework
to
achieve
potent
LPZ
can
adhere
cell
membranes
through
interaction
between
pili
LGG
mucin
cells.
In
particular,
adaptive
formula
gradually
enhance
ability
nanozymes
produce
creating
acidic
microenvironment
anaerobic
respiration.
These
results
verify
that
could
generate
high
levels
both
on
within
cells,
leading
pyroptotic
death
strong
antitumor
immunity.
Meanwhile,
eventually
killed
this
process
halt
their
respiration
prevent
potential
biosafety
concerns.
Overall,
work
provides
new
inspiration
design
nanocatalytic
drugs
Abstract
The
induction
of
regulated
cell
death
(RCD)
through
photo/ultrasound
sensitization
therapeutic
agents
has
gained
significant
attention
as
a
vital
approach
to
combat
drug
resistance
in
tumors.
Aggregation‐induced
emission
(AIE)
generate
reactive
oxygen
species
activation,
which
can
synergize
with
RCD
inducers
or
directly
induce
RCD,
ultimately
resulting
the
tumor
cells.
presented
comprehensive
review
delves
into
recent
advancements
AIE
designed
trigger
inducers,
encompassing
apoptosis,
necroptosis,
pyroptosis,
immunogenic
death,
autophagy,
ferroptosis,
and
cuproptosis.
Additionally,
intricate
regulatory
mechanisms
activatory‐AIE
therapeutics
influence
distinct
pathways
are
examined.
A
forward‐looking
perspective
on
future
developments
pertinent
challenges
within
this
exciting
realm
is
presented,
anticipating
continued
evolution
activatable
transformative
enhance
therapy.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 29, 2024
Given
the
crucial
role
of
abnormal
homeostasis
in
tumor
cells
for
maintaining
their
growth,
it
may
be
more
efficient
with
less
effort
to
develop
anti-tumor
strategies
that
target
multiple
combined
mechanisms
by
disrupting
intracellular
homeostasis.
Here,
a
copper-based
nanoinducer
(CGBH
NNs)
enzyme-like
activities
is
designed
and
constructed
induce
disulfidptosis-enhanced
pyroptosis
through
effective
immunotherapy.
Within
microenvironment
(TME),
CGBH
NNs
can
disrupt
glucose
inhibit
NADPH
production,
leading
accumulation
cystine,
which
further
blocked
substrate
key
enzyme
synthesizing
glutathione.
Subsequently,
cascade
catalytic
reactions
involving
(glutathione
peroxidase-like,
oxidase
peroxidase-like
activities),
produce
massive
reactive
oxygen
species
(ROS)
redox
homeostasis,
resulting
pyroptosis.
The
undergoing
immunogenic
release
various
cytosolic
contents
inflammatory
factors,
eliciting
robust
immune
responses
facilitating
cell
infiltration,
reprogramming
immunosuppressive
TME.
After
combination
checkpoint
blockade
therapy,
effectively
suppress
growth
prolong
survival
time
tumor-bearing
mice.
This
work
presents
novel
paradigm
trigger
destroying
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(46)
Опубликована: Июнь 10, 2024
Abstract
Immunotherapy,
one
of
the
most
promising
antitumor
strategies,
is
used
to
treat
prostate
cancer
(PCa).
However,
owing
immunosuppressive
tumor
microenvironment
(TME),
therapeutic
effect
immune
response
greatly
weakened.
Therefore,
there
an
urgent
need
explore
new
methods
enhance
responses.
In
this
study,
a
single‐atom
nanozyme
platform
(Cu
SA‐DOX@COD)
that
can
trigger
pyroptosis
developed
activate
responses
via
gasdermin
E
(GSDME)‐dependent
pathway.
It
triggered
by
catalyzing
production
reactive
oxygen
species
(ROS)
and
depleting
reduced
glutathione
through
intrinsic
multi‐enzyme
simulated
activities
providing
source
for
cholesterol
(CHOL)
oxidation.
Meanwhile,
loaded
CHOL
oxidase
not
only
reduces
content
cells
increase
cell
membrane
permeability
inhibit
proliferation
invasion
but
also
oxidizes
increases
level
H
2
O
in
pyroptosis.
addition,
doxorubicin
activated
caspase‐3
cleave
GSDME
further
augment
Consequently,
Cu
SA‐DOX@COD
enhances
immunocompetence
reshapes
TME
triggering
caused
ROS
storm,
chemotherapy,
CHOL,
thereby
activating
systemic
immunity
PCa.