Abstract
Current
radiotherapy
(RT)
lacks
the
ability
to
accurately
discriminate
between
tumor
and
healthy
tissues,
resulting
in
significant
radiation‐induced
damage
for
patients.
Therefore,
there
is
an
urgent
need
precise
RT
techniques
that
can
optimize
control
while
minimizing
adverse
effects
on
surrounding
tissues.
In
this
study,
we
developed
a
nanodrug
(AuNR@Peptide)
composed
of
furin‐responsive
RVRR
peptide‐conjugated
AuNRs,
which
integrates
activatable
probe
radiosensitizer
into
single
system
accurate
localization,
enabling
image‐guided
precision
RT.
Upon
reaching
site
after
intravenous
administration,
proteolytic
cleavage
substrates
AuNR@Peptide
by
biomarker
triggers
aggregation
gold
nanorods
(AuNRs)
larger
aggregates,
leading
activation
near‐infrared
(NIR)‐II
photoacoustic
(PA)
signals
precisely
localize
enhance
retention
preventing
migration
backflow
AuNRs.
This
significantly
amplifies
radiosensitivity
efficiency.
The
peak
time
point
at
NIR‐II
PA
signal
was
observed
injection
serves
as
reference
initiating
RT,
demonstrating
substantial
improvement
through
investigations
related
radiosensitization
mechanisms.
integration
imaging
therapy
study
offers
promising
therapeutic
modality
tumors.
Nanomaterials,
Год журнала:
2024,
Номер
14(9), С. 797 - 797
Опубликована: Май 3, 2024
Nanomaterials,
with
unique
physical,
chemical,
and
biocompatible
properties,
have
attracted
significant
attention
as
an
emerging
active
platform
in
cancer
diagnosis
treatment.
Amongst
them,
metal–organic
framework
(MOF)
nanostructures
are
particularly
promising
a
nanomedicine
due
to
their
exceptional
surface
functionalities,
adsorption
organo-inorganic
hybrid
characteristics.
Furthermore,
when
bioactive
substances
integrated
into
the
structure
of
MOFs,
these
materials
can
be
used
anti-tumor
agents
superior
performance
compared
traditional
nanomaterials.
In
this
review,
we
highlight
most
recent
advances
MOFs-based
for
tumor
therapy,
including
application
treatment
underlying
mechanisms.
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 20, 2024
Concurrent
localized
radiotherapy
and
systemic
chemotherapy
are
standards
of
care
for
many
cancers,
but
these
treatment
regimens
cause
severe
adverse
effects
in
patients.
Herein,
we
report
the
design
a
mixed-ligand
nanoscale
metal–organic
framework
(nMOF)
with
ability
to
simultaneously
enhance
radiotherapeutic
trigger
release
potent
chemotherapeutic
under
X-ray
irradiation.
We
synthesized
new
functional
quaterphenyl
dicarboxylate
ligand
conjugated
SN38
(H2QP-SN)
via
hydroxyl
radical-responsive
covalent
linkage.
Because
similar
length
QP-SN
bis(p-benzoato)porphyrin
(DBP)
ligands,
was
incorporated
into
Hf-DBP
nMOF
afford
novel
multifunctional
Hf-DBP-QP-SN
good
biocompatibility.
not
only
enhances
radiation
damage
tumors
unique
radiotherapy-radiodynamic
therapy
(RT-RDT)
process
also
increases
·OH
generation
from
radiolysis
electron-dense
Hf12
secondary
building
units
(SBUs)
chemotherapy.
Elevated
levels
hydrogen
peroxide
tumor
microenvironment
further
stimulate
by
enhancing
With
low
doses
irradiation,
suppressed
growth
CT26
colon
4T1
breast
93.5%
95.2%,
respectively,
without
any
sign
general
toxicity.
Our
study
highlights
potential
using
ionizing
radiation-mediated
chemistry
on-demand
activation
nanotherapeutics
synergistic
causing
effects.
Journal of Photochemistry and Photobiology,
Год журнала:
2024,
Номер
23, С. 100245 - 100245
Опубликована: Июль 11, 2024
Metal
organic
frameworks
(MOFs)
consist
of
metal
atoms
or
clusters,
coordinated
to
ligands
form
macromolecular
super
structures,
with
pores
large
enough
host
free
drug
molecules,
including
photodynamic
therapy
(PDT)
photosensitizers.
This
review
presents
examples
applications
in
PDT
various
types
MOFs.
To
contextualize
the
discussions
their
applications,
general
procedures
MOF
synthesis
are
considered.
Applications
MOFs
described
using
several
combination
innovations
developed
for
purpose
solving
some
key
challenges
clinical
translation
value
chain
PDT.
The
evidence
show
that
explosion
research
is
due
capability
as
carriers
and
delivery
systems
It
also
shows
unique
platforms
therapies,
stimulus
responsive
release
photosensitizer
cancer
cell
targeting,
auxiliary
enhancement
efficacy.
Published
literature
on
has
been
rise
since
eighties.
In
Scopus,
increased
from
1
article
2010,
169
articles
2023,
whereas
published
generally,
878
11644
during
this
period.
Research
therefore
more
than
generally.
Literature
by
between
0.7%
1.45%
relative
Clearly,
researched
overcome
improve
efficacy,
they
Abstract
Current
radiotherapy
(RT)
lacks
the
ability
to
accurately
discriminate
between
tumor
and
healthy
tissues,
resulting
in
significant
radiation‐induced
damage
for
patients.
Therefore,
there
is
an
urgent
need
precise
RT
techniques
that
can
optimize
control
while
minimizing
adverse
effects
on
surrounding
tissues.
In
this
study,
we
developed
a
nanodrug
(AuNR@Peptide)
composed
of
furin‐responsive
RVRR
peptide‐conjugated
AuNRs,
which
integrates
activatable
probe
radiosensitizer
into
single
system
accurate
localization,
enabling
image‐guided
precision
RT.
Upon
reaching
site
after
intravenous
administration,
proteolytic
cleavage
substrates
AuNR@Peptide
by
biomarker
triggers
aggregation
gold
nanorods
(AuNRs)
larger
aggregates,
leading
activation
near‐infrared
(NIR)‐II
photoacoustic
(PA)
signals
precisely
localize
enhance
retention
preventing
migration
backflow
AuNRs.
This
significantly
amplifies
radiosensitivity
efficiency.
The
peak
time
point
at
NIR‐II
PA
signal
was
observed
injection
serves
as
reference
initiating
RT,
demonstrating
substantial
improvement
through
investigations
related
radiosensitization
mechanisms.
integration
imaging
therapy
study
offers
promising
therapeutic
modality
tumors.
