Nitric Oxide‐Releasing Nanoscale Metal‐Organic Layer Overcomes Hypoxia and Reactive Oxygen Species Diffusion Barriers to Enhance Cancer Radiotherapy

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Abstract Hafnium (Hf)‐based nanoscale metal‐organic layers (MOLs) enhance radiotherapeutic effects of tissue‐penetrating X‐rays via a unique radiotherapy‐radiodynamic therapy (RT‐RDT) process through efficient generation hydroxy radical (RT) and singlet oxygen (RDT). However, their efficacy is limited by hypoxia in deep‐seated tumors short half‐lives reactive species (ROS). Herein the conjugation nitric oxide (NO) donor, S‐nitroso‐N‐acetyl‐DL‐penicillamine (SNAP), to Hf 12 secondary building units (SBUs) Hf‐5,5′‐di‐p‐benzoatoporphyrin MOL reported afford SNAP/MOL for enhanced cancer radiotherapy. Under X‐ray irradiation, efficiently generates superoxide anion (O 2 −. ) releases spatio‐temporally synchronized fashion. The released NO rapidly reacts with O form long‐lived highly cytotoxic peroxynitrite which diffuses freely cell nucleus causes DNA double‐strand breaks. Meanwhile, sustained release from tumor microenvironment relieves reduce radioresistance cells. Consequently, plus low‐dose irradiation inhibits growth reduces metastasis colorectal triple‐negative breast models.

Language: Английский

---

Beyond chemotherapy: Spatiotemporal activation of metal complexes for deep-tissues precision medicine

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 535, P. 216664 - 216664

Published: March 30, 2025

Language: Английский

---

Metal-Organic Frameworks as Therapeutic Chameleons: Revolutionizing the Cancer Therapy Employing Novel Nanoarchitectonics

Asian Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 101054 - 101054

Published: April 1, 2025

Language: Английский

---

Unlocking the Potential of Disulfidptosis: Nanotechnology‐Driven Strategies for Advanced Cancer Therapy

Small, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract Tumor tissues exhibit elevated oxidative stress, with the cystine‐glutamate transporter x CT solute carrier family 7 member 11 ( CT/SLC7A11) protecting cancer cells from damage by facilitating cystine uptake for glutathione synthesis. Disulfidptosis, a newly identified form of programmed cell death (PCD), occurs in high CT/SLC7A11 expression under glucose‐deprived conditions. Distinct other PCD pathways, disulfidptosis is characterized aberrant disulfide bond formation and cellular dysfunction, ultimately resulting death. This novel mechanism offers remarkable therapeutic potential targeting inherent stress vulnerabilities rapidly growing cells. Advances nanotechnology enable development nanomaterials capable inducing reactive oxygen species (ROS) generation, disrupting bonds. In addition, they are to deliver agents directly tumors, thereby improving precision minimizing off‐target effects. Moreover, combining ROS‐induced immunogenic can remodel tumor microenvironment enhance anti‐tumor immunity. review explores mechanisms underlying disulfidptosis, its treatment, synergistic role amplifying Selective induction using represents promising strategy achieving more effective, selective, less toxic therapies.

Language: Английский

---

Empowering radiotherapy: Harnessing nanomedicines to enhance radiation response and boost antitumor efficacy

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 520, P. 216140 - 216140

Published: Aug. 13, 2024

Language: Английский

---