ABSTRACT
Objective
The
aim
of
this
study
is
to
explore
the
mechanism
benzylurea
in
inflammatory
injury
human
periodontal
ligament
fibroblasts
(hPDLFs).
Methods
An
inflammation
model
hPDLFs
was
established
using
LPS.
Nuclear
transport
nuclear
transcription
factor‐κB
(NF‐κB),
secretion
cytokines,
and
morphology
distribution
F‐actin
were
determined.
Mitochondrial
function
assessed
by
measuring
mitochondrial
membrane
potential
(MMP),
permeability
transition
pore
(mPTP),
reactive
oxygen
species
(ROS)
levels.
expression
carrier
homolog
2
(MTCH2)
Cytochrome
b5
type
B
(CYB5B)
detected.
Results
Benzylurea
alleviated
effects
lipopolysaccharide
(LPS)
on
proliferation
apoptosis
hPDLFs.
It
reduced
release
cytokines
inhibited
NF‐κB
translocation.
improved
regulating
MMP
preventing
excessive
mPTP
opening.
Furthermore,
LPS
elevated
MTCH2
CYB5B
However,
these
can
be
benzylurea.
altered
directly
affected
expression,
activation
translocation
NF‐κB.
Conclusion
may
act
as
an
effector
MTCH2,
with
enhancing
protecting
from
LPS‐induced
through
MTCH2.
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(19), С. 12901 - 12906
Опубликована: Май 3, 2024
Cholesterol-rich
membranes
play
a
pivotal
role
in
cancer
initiation
and
progression,
necessitating
innovative
approaches
to
target
these
for
inhibition.
Here
we
report
the
first
case
of
unnatural
peptide
(1)
assemblies
capable
depleting
cholesterol
inhibiting
cells.
Peptide
1
self-assembles
into
micelles
is
rapidly
taken
up
by
cells,
especially
when
combined
with
an
acute
cholesterol-depleting
agent
(MβCD).
Click
chemistry
has
confirmed
that
depletes
cell
membrane
cholesterol.
It
localizes
membrane-rich
organelles,
including
endoplasmic
reticulum,
Golgi
apparatus,
lysosomes.
Furthermore,
potently
inhibits
malignant
working
synergistically
cholesterol-lowering
agents.
Control
experiments
have
C-terminal
capping
amino
acid
residues
(i.e.,
BiP)
are
essential
both
depletion
potent
This
work
highlights
as
promising
platform
targeting
controlling
fates.
Antioxidants,
Год журнала:
2024,
Номер
13(6), С. 697 - 697
Опубликована: Июнь 6, 2024
Glutathione
(GSH),
a
prominent
antioxidant
in
organisms,
exhibits
diverse
biological
functions
and
is
crucial
safeguarding
cells
against
oxidative
harm
upholding
stable
redox
milieu.
The
metabolism
of
GSH
implicated
numerous
diseases,
particularly
the
progression
malignant
tumors.
Consequently,
therapeutic
strategies
targeting
regulation
synthesis
to
modulate
levels
represent
promising
avenue
for
future
research.
This
study
aimed
elucidate
intricate
relationship
between
ferroptosis,
highlighting
how
modulation
can
impact
cellular
susceptibility
ferroptosis
consequently
influence
development
tumors
other
diseases.
paper
provides
comprehensive
overview
physiological
GSH,
including
its
structural
characteristics,
physicochemical
properties,
sources,
metabolic
pathways,
as
well
investigate
molecular
mechanisms
underlying
potential
interventions.
Unraveling
role
holds
promise
individuals
afflicted
with
Accounts of Chemical Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 19, 2025
ConspectusEmulating
the
structural
features
or
functions
of
natural
systems
has
been
demonstrated
as
a
state-of-the-art
strategy
to
create
artificial
functional
materials.
Inspired
by
assembly
and
bioactivity
proteins,
self-assembly
peptides
into
nanostructures
represents
promising
approach
for
creating
biomaterials.
Conventional
assembled
peptide
biomaterials
are
typically
formulated
in
solution
delivered
pathological
sites
implementing
theranostic
objectives.
However,
this
translocation
entails
switch
from
formulation
conditions
physiological
environment
raises
concerns
about
material
performance.
In
addition,
precise
efficient
accumulation
administered
at
target
remains
significant
challenge,
leading
potential
biosafety
issues
associated
with
off-target
effects.
These
limitations
significantly
hinder
progress
advanced
To
address
these
concerns,
past
few
years
have
witnessed
development
situ
living
new
endeavor
optimizing
biomaterial
performance
benefiting
advances
stimuli-responsive
reactions
regulating
noncovalent
interactions.
refers
processes
via
sites.
Due
advantages
precisely
forming
well-defined
lesions,
situ-formed
assemblies
integrated
interesting
next-generation
biomedical
agents.Despite
great
developing
agents,
research
area
still
suffers
limited
toolkit
operating
under
complicated
conditions.
Considering
amino
acids
being
incorporated
backbones
modified
units,
an
acid
is
concern.
Therefore,
our
laboratory
intensively
engaged
designing
discovering
noncanonical
(ncAAs)
expand
manipulating
various
biological
Thus
far,
we
synthesized
containing
ncAAs
4-aminoproline,
2-nitroimidazole
alanine,
Se-methionine,
sulfated
tyrosine,
glycosylated
serine,
which
allow
us
develop
acid-responsive,
redox-responsive,
enzyme-responsive
systems.
Based
on
ncAAs,
established
complex
self-sorting
assembly,
self-amplified
dissipative
cells
optimize
peptides.
The
resulting
exhibit
morphological
adaptability
microenvironment,
contributes
overcoming
delivery
barriers
improvement
targeting
accumulation.
utilizing
developed
toolkit,
further
created
supramolecular
PROTACs,
antagonists,
probes
cancer
treatment
diagnosis
highlight
implications
usage.
Account,
summarize
journey
emphasis
mechanism
Eventually,
also
provide
forward
conceiving
prospects
challenges
clinical
translation
situ-formulated
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
The
need
to
enhance
the
precision
and
specificity
of
therapeutic
nanocarriers
has
led
development
nanoscale
peptide
assemblies
capable
sensing
responding
disease-related
analytes.
ACS Applied Polymer Materials,
Год журнала:
2024,
Номер
6(7), С. 4331 - 4338
Опубликована: Март 29, 2024
Supramolecular
assemblies
based
on
multiple
host–guest
interactions
have
aroused
widespread
interest
in
the
fabrication
of
innovative
biomaterials.
In
this
work,
a
combinational
nanosupramolecule
is
constructed
by
an
orthogonal
two-step
self-assembling
process.
The
generation
efficiency
reactive
oxygen
species
and
fluorescence
emission
intensity
pyridinium-appended
porphyrin
are
greatly
enhanced
upon
inclusion
complexation
with
cucurbit[8]uril.
Meanwhile,
introduction
β-cyclodextrin-grafted
hyaluronic
acid
can
facilitate
formation
secondary
endow
them
desired
targeting
ability
toward
cancer
cells.
After
carrying
doxorubicin
hydrochloride
as
loaded
cargo,
resultant
supramolecular
nanoparticles
exhibit
much
higher
anticancer
activity
at
cellular
level
near-infrared
light
irradiation.
To
be
envisioned,
such
nanosupramolecular
featuring
both
advantageous
photodynamic
chemotherapeutic
effects
may
developed
more
promising
nanoplatforms
for
disease
diagnosis
treatment.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(48)
Опубликована: Авг. 22, 2024
Abstract
Natural
dissipative
assembly
(DSA)
often
exhibit
energy‐driven
shifts
in
natural
functions.
However,
creating
man‐made
DSA
that
can
mimic
such
biological
activities
transformation
remains
relatively
rare.
Herein,
we
introduce
a
cytomembrane‐like
system
based
on
chiral
supramolecules.
This
employs
benzoyl
cysteine
an
out
of
equilibrium
manner,
enabling
the
biofunctions
while
minimizing
material
use.
Specifically,
aroyl‐cystine
derivatives
primarily
assemble
into
stable
M‐helix
nanofibers
under
conditions.
These
enhance
fibroblast
adhesion
and
proliferation
through
stereospecific
interactions
with
cellular
membranes.
Upon
addition
chemical
fuels,
these
functional
temporarily
transform
non‐equilibrium
nanospheres,
facilitating
efficient
drug
delivery.
Subsequently,
nanospheres
revert
to
their
original
nanofiber
state,
effectively
recycling
drug.
The
programmable
function‐shifting
ability
this
establishes
it
as
novel,
fuel‐driven
delivery
vehicle.
And
bioactive
not
only
addresses
gap
synthetic
DSAs
within
applications
but
also
sets
stage
for
innovative
designs
′living′
materials.
Molecules,
Год журнала:
2024,
Номер
29(19), С. 4705 - 4705
Опубликована: Окт. 4, 2024
Amino
acids
(AAs),
serving
as
the
primary
monomer
of
peptides
and
proteins,
are
widely
present
in
nature.
Benefiting
from
their
inherent
advantages,
such
chemical
diversity,
low
cost,
ease
modification,
chirality,
biosafety,
bio-absorbability,
AAs
have
been
extensively
exploited
to
create
self-assembled
nanostructures
supramolecular
soft
materials.
In
this
review
article,
we
systematically
describe
recent
progress
regarding
amino
acid-derived
assembly
functional
A
brief
background
several
classified
assemblies
derivatives
(chemically
modified
AAs)
summarized.
The
key
non-covalent
interactions
drive
emphasized
based
on
reported
systems
co-assembled
AAs.
We
discuss
molecular
design
general
rules
behind
hierarchical
nanostructures.
resulting
materials
with
interesting
properties
potential
applications
demonstrated.
conclusion
remarks
AA-based
also
presented
viewpoint
chemistry,
materials,
bio-applications.
