Angewandte Chemie,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 13, 2024
Abstract
The
use
of
abundant
and
inexpensive
fluorine
feedstocks
to
synthesize
fluorinated
compounds
is
a
promising
strategy
that
has
not
been
extensively
investigated.
Dibromodifluoromethane
(CF
2
Br
)
an
source
rarely
used
for
C−H
fluoroalkylation.
This
study
reveals
iridium‐catalyzed,
tunable
synthesizing
acyl
fluorides
difluorobromomethylated
products
using
CF
.
To
achieve
the
desired
products,
this
process
only
requires
change
solvent
(from
DMSO
1,4‐dioxane)
under
blue
LED
illumination.
A
variety
arenes
heteroarenes
with
electron‐donating
substituents
were
successfully
used,
yielding
corresponding
in
moderate
good
yields.
Mechanistic
experiments
revealed
served
dual
role,
functioning
as
both
nucleophilic
reagent
fluorocarbonylation.
The
development
of
different
concept
approaches
and
user-friendly
carbonyl
surrogates
for
aminocarbonylation
is
highly
desirable.
Herein,
we
report
the
photocatalytic
enaminones
with
easily
available
o-aminobenzamides
CF2Br2
through
an
oxygen
migration-defluorination
strategy.
reaction
features
switchable
transformation
construction
carbamoyl-substituted
enol
products
allows
expedient
synthesis
fully
substituted
maleimides
under
mild
conditions.
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
27(10)
Опубликована: Фев. 14, 2024
Abstract
A
Pd‐catalyzed
three‐component
intermolecular
reaction
between
aryl
halides,
ClCF
2
COONa
and
phenols
is
developed.
series
of
benzoates
were
synthesized
in
up
to
84
%
yield
via
difluorocarbene
transfer
carbonylation.
It
devoted
acquiring
the
targeted
products
by
construction
new
C−C,
C=O
C−O
bonds
a
one‐pot,
one‐step
process.
The
feature
this
method
includes
use
readily
available
starting
materials,
showing
outstanding
resistance
spatial
obstruction
simple
operation
procedure
with
mild
conditions.
Therefore,
makes
methodology
useful
alternative
other
schemes
typically
used
for
synthesis
esters.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(15), С. 4214 - 4218
Опубликована: Янв. 1, 2024
A
[3
+
1
1]
cascade
annulation
reaction
for
the
divergent
construction
of
trisubstituted
indolizines
using
sulfoxonium
ylides,
BrCF
2
CO
Me
and
pyridinium
salts
as
readily
available
substrates
has
been
developed.
Organic Letters,
Год журнала:
2024,
Номер
26(37), С. 7834 - 7840
Опубликована: Сен. 5, 2024
The
Narasaka-Heck
reaction
is
one
of
the
most
straightforward
methods
for
constructing
pyrroline
derivatives.
Herein,
we
report
a
novel
nickel-catalyzed
three-component
carbonylation
reaction,
which
cleverly
realizes
continuous
construction
C(sp
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(12), С. 3491 - 3496
Опубликована: Янв. 1, 2024
The
use
of
a
ligand
to
tune
palladium-catalyzed
intramolecular
Heck
gem
-difluorovinylation
and
carboxylation
is
reported.
Sodium
difluorochloroacetate
(ClCF
2
COONa)
acts
as
both
difluorocarbene
(:CF
)
carboxyl
source.
Through
the
prosperity
of
organofluorine
chemistry
in
modern
organic
synthesis,
perfluorinated
compounds
are
now
abundant
and
widely
available.
Consequently,
these
substances
become
attractive
starting
materials
for
production
complex,
multifunctional
fluorinated
molecules.
However,
inherent
challenges
associated
with
activation
discrimination
C–F
bonds
typically
lead
to
overdefluorination
as
well
functional
group
incompatibility.
To
address
problems,
our
utilized
a
rationally
designed
organophosphorus
reagent
that
promoted
mild
selective
manipulation
single
bond
trifluoromethyl
pentafluoroethyl
ketones
via
an
interrupted
Perkow-type
reaction,
which
allowed
replacement
fluorine
more
labile
synthetically
versatile
congeners
such
chlorine,
bromine,
iodine.
The
resulting
α-haloperfluoroketones
have
two
reactive
units
orthogonal
properties
would
be
suitable
subsequent
structural
diversification.
DFT
calculations
identified
favorable
P–F
interaction
crucial
factor
from
both
thermodynamic
kinetic
viewpoints.
The Chemical Record,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 27, 2025
Abstract
Palladium‐catalyzed
carbonylative
reactions,
used
as
a
tool
for
the
insertion
of
carbonyl
group
into
organic
moieties,
is
synthetically
useful
transformation.
Carbonylative
Sonogashira
coupling
convenient
approach
synthesis
α,β‐acetylenic
ketones
which
are
important
class
molecules
in
pharmaceutical
and
industrial
fields.
Development
greener
approaches
environmentally
benign
catalytic
systems
put
forward
enormous
opportunities
this
field
moreover,
these
researches
indicate
formation
heterocycles
via
carbonylation
strategy,
major
highlight.
Herein,
we
discuss
progress
achieved
palladium‐catalyzed
from
2013
to
2024
its
future
prospects.
