Enhancing electrochemical reactions in organic synthesis: the impact of flow chemistry

Chemical Society Reviews, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Utilizing electrons directly offers significant potential for advancing organic synthesis by facilitating novel reactivity and enhancing selectivity under mild conditions. As a result, an increasing number of chemists are exploring electrosynthesis. However, the efficacy electrochemical transformations depends critically on design cell. Batch cells often suffer from limitations such as large inter-electrode distances poor mass transfer, making flow promising alternative. Implementing cells, however, requires foundational understanding microreactor technology. In this review, we briefly outline applications electrosynthesis before providing comprehensive examination existing reactor technologies. Our goal is to equip with insights needed tailor their meet specific requirements effectively. We also highlight application designs in scaling up processes integrating high-throughput experimentation automation. These advancements not only enhance synthetic community but hold promise both academia industry.

Язык: Английский

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Synthesis of Non-C₂-Symmetric Biaryldiols via Organo-Electro Catalyzed Aryl–Aryl Dehydrogenative Cross-Coupling

Journal of the American Chemical Society, Год журнала: 2025, Номер 147(9), С. 7524 - 7532

Опубликована: Фев. 19, 2025

Despite a few successful examples, controlling the enantioselectivity in asymmetric synthesis of non-C2-symmetric biaryldiols has long been challenging. To address issues and regioselectivity, we introduced novel organoelectrocatalytic strategy enabling aryl-aryl dehydrogenative cross-coupling reactions. Using this approach, valuable were obtained up to 95% yields 97% enantiomeric excesses (ees), these compounds could be further applied as versatile ligands Detailed mechanistic studies supported sequential diradical followed by central-to-axial chirality conversion pathway.

Язык: Английский

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N–N Atropisomer Synthesis via Electrolyte- and Base-Free Electrochemical Cobalt-Catalysed C–H Annulation

Green Chemistry, Год журнала: 2024, Номер 26(23), С. 11524 - 11530

Опубликована: Янв. 1, 2024

An exogenous electrolyte- and base-free electrochemical cobalt-catalysed atroposelective C–H annulation has been established to construct N–N axially chiral isoquinolinones in excellent enantioselectivities good yields.

Язык: Английский

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Wireless asymmetric umpolung electrosynthesis

Chemical Communications, Год журнала: 2024, Номер 60(74), С. 10120 - 10123

Опубликована: Янв. 1, 2024

Electroorganic synthesis has become an exciting tool for the asymmetric conversion of pro-chiral compounds. Herein, we introduced a wireless methodology based on bipolar electrochemistry in synergy with enantioselective capabilities inherently chiral oligomers to induce umpolung chirality transfer. This was exemplified by electro-conversion racemic mixture lansoprazole

Язык: Английский

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Electrochemical N–H Methylsulfoxidation of Sulfoximines with DMSO

Chinese Journal of Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 16, 2025

Comprehensive Summary The N–H methylsulfoxidation of sulfoximines using DMSO as a methylsulfinyl source, induced by electrochemistry, has been developed. This method is the first example an electrochemical reaction in which serves source. Unlike previous reactions involving substrate, exclusively proceed via radical mechanisms, this follows S‐cation pathway. A wide range N ‐methylsulfinyl were successfully obtained.

Язык: Английский

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Electrochemical cobalt-catalyzed semi-deuteration of alkynes to access deuterated Z-alkenes

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Март 10, 2025

Abstract Deuterium labeling has found extensive applications across various research fields, including organic synthesis, drug design, and molecular imaging. Electrocatalytic semi-hydrogenation of alkynes offers a viable route for the synthesis Z -alkenes, yet it falls short in achieving semi-deuteration these compounds. In this study, we report an electrochemical cobalt-catalyzed transfer deuteration reaction that proficiently accomplishes alkynes, yielding -configuration deuterated alkene products. This utilizes cost-effective cobalt salts as catalysts employs D 2 O AcOD (acetic acid- d ) economical efficient deuterium sources, underscoring its practicality feasibility. The demonstrates broad alkyne substrate scope, high efficiency, good functional group compatibility, excellent -selectivity, remarkable degree rate.

Язык: Английский

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Supramolecular Engineering of Metal–Organic Membranes with Metal‐Support Interactions for Nanoconfined Synergistic Catalysis

Small Methods, Год журнала: 2025, Номер unknown

Опубликована: Апрель 21, 2025

Abstract Continuous‐flow nanoconfined catalysis is crucial for rapid and efficient water purification but challenging traditional reactors. Supramolecular metal–organic membranes, with their intrinsically rich metal nodes, present promising opportunities heterogeneous nano‐catalysis. However, achieving a uniform distribution stabilization of exposed active sites remains challenge. Here, phosphotungstic acid (H 3 PW 12 O 40 : ) modulated interfacial coordination strategy introduced to engineer thin palladium‐1,3,5‐triformylphloroglucinol (Pd‐Tp) nanofilm. The strong electrostatic‐dominated interaction between the fourfold hollow site Pd II enables in situ confined reduction, facilitating enhanced loading cluster‐shaped Pd‐PW nanoparticles within layer. hydrophilic Tp leads competition PdCl 4 2‐ during film formation, giving rise thinner, more hydrophilic, loose‐structured membranes. Importantly, PCM/NaBH system exhibits superior reducibility electron transfer capacity, enabling degradation range organic contaminants, attributed robust metal‐support interactions. PCM achieves rate constant target pollutant 4‐nitrophenol (97.8 ms −1 ), which 175 times faster than that control HCM (0.56 ). This study highlights role microstructure modulation membrane synergistic catalysis.

Язык: Английский

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Researches on the Growth of Lithium Deposition in Lithium‐Ion Batteries During Long‐Term Cycling of Slight Overcharging

Energy Technology, Год журнала: 2025, Номер unknown

Опубликована: Май 15, 2025

In the entire life cycle of lithium‐ion batteries, there may be long‐term cycling overcharging conditions. Therefore, a high‐fidelity model that is analyzed for physical characteristics batteries during conditions required. Based on pseudo‐2D (P2D) model, P2D with variable solid‐phase diffusion coefficient electrochemical built. This used to study changes in properties automotive including relative capacity, generation lithium metal deposition, and solid electrolyte interface (SEI) film. The SEI film deposition have been under different charge/discharge rates values overcharge It found plating influenced by both overcharged value charging current rate. Lithium has greater impact capacity fading than films. There competition between films process, inhibits dendrite always grow parallel coupling.

Язык: Английский

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A highly stable metallosalen-based metal–organic framework electrocatalyst for versatile oxidative organic transformations

Journal of Catalysis, Год журнала: 2025, Номер unknown, С. 116252 - 116252

Опубликована: Май 1, 2025

Язык: Английский

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Electroreductive Carboxylation of Benzylphosphonium salts with CO2 Through the Cleavage of the C(sp3)-P Bond

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(28), С. 5724 - 5728

Опубликована: Янв. 1, 2024

Herein, a novel electroreductive carboxylation of benzylphosphine salts with CO 2 through cleavage the C(sp 3 )-P bond was reported under conditions without redox reagents and noble metal catalysts.

Язык: Английский

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