Recent Advances and Future Developments in the Preparation of Polypeptides via N-Carboxyanhydride (NCA) Ring-Opening Polymerization
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(35), С. 24189 - 24208
Опубликована: Авг. 22, 2024
Polypeptides
have
the
same
or
similar
backbone
structures
as
proteins
and
peptides,
rendering
them
suitable
important
biomaterials.
Amino
acid
N-carboxyanhydrides
(NCA)
ring-opening
polymerization
has
been
most
efficient
strategy
for
polypeptide
preparation,
with
continuous
advance
in
design
of
initiators,
catalysts
reaction
conditions.
This
Perspective
first
summarizes
recent
progress
NCA
synthesis
purification.
Subsequently,
we
focus
on
various
initiators
polymerization,
accelerating
enhancing
controllability
advances
approach
polymerization.
Finally,
discuss
future
research
directions
open
challenges.
Язык: Английский
Integrating synthetic polypeptides with innovative material forming techniques for advanced biomedical applications
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 12, 2025
Polypeptides
are
highly
valued
in
biomedical
science
for
their
biocompatibility
and
biodegradability,
making
them
valuable
drug
delivery,
tissue
engineering,
antibacterial
dressing.
The
diverse
design
of
polymer
chains
self-assembly
techniques
allow
different
side
secondary
structures,
enhancing
potential.
However,
the
traditional
solid
powder
form
polypeptides
presents
challenges
skin
applications,
shipping,
recycling,
limiting
practical
utility.
Recent
advancements
material
forming
methods
polypeptide
synthesis
have
produced
biomaterials
with
uniform,
distinct
shapes,
improving
usability.
This
review
outlines
progress
material-forming
over
past
decade.
main
include
solid-phase
ring-opening
polymerization
N-carboxyanhydrides
while
like
electrospinning,
3D
printing,
coating
explored.
Integrating
structural
these
is
emphasized,
leading
to
materials
unique
shapes.
also
identifies
research
hotspots
using
VOSviewer
software,
which
visually
presented
circular
packing
images.
It
further
discusses
emerging
applications
such
as
wound
healing,
emphasizing
crucial
role
shape
performance.
concludes
by
exploring
future
trends
developing
shapes
advanced
encouraging
research.
Язык: Английский
Synthetic Polymers for Drug, Gene, and Vaccine Delivery
Polymer science & technology.,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 25, 2025
Язык: Английский
Chiral polymer micro/nano-objects: evolving preparation strategies in heterogeneous polymerization
Science China Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 13, 2024
Язык: Английский
Supramolecular chirality capture in solvent monomer-based co-assemblies via in situ photopolymerization
Chemical Communications,
Год журнала:
2024,
Номер
60(68), С. 9054 - 9057
Опубликована: Янв. 1, 2024
The
supramolecular
chirality
of
a
co-assembly
pyridine-cholesterol
gelator
and
solvent
monomer
is
captured
via
in
situ
photopolymerization.
Doping
with
achiral
dyes
enables
the
creation
multi-color
CPL
polymer
films
inverted
handedness.
Язык: Английский
Strong Bioadhesives from Helical Polypeptides
Jiangyan Shi,
Liufen Kong,
Ning Wang
и другие.
ACS Macro Letters,
Год журнала:
2025,
Номер
14(3), С. 299 - 305
Опубликована: Фев. 21, 2025
Bioadhesives
have
emerged
as
versatile
and
powerful
tools
for
tissue
repair
integration
with
biomedical
devices,
offering
a
wide
range
of
applications
that
captured
significant
clinical
scientific
interest.
Synthetic
polypeptide
adhesives
are
particularly
promising
candidates
bioadhesives,
but
often
face
limitations
in
adhesive
strength.
In
this
study,
inspired
by
marine
proteins,
the
secondary
structure
hydrophobic–hydrophilic
balance
polypeptides
were
precisely
regulated
to
transform
polyelectrolyte
strong
adhesive.
The
resulting
demonstrated
an
strength
exceeding
1.0
MPa,
more
than
10×
higher
previously
reported
synthetic
cohesion
adhesion
can
be
optimized
adjusting
content
hydrophobic
residue
ratios.
More
helices
enhance
interactions
between
backbone
side
chains
well
substrates.
addition,
these
exhibit
excellent
tolerance
acids
or
alkalis,
remarkable
variable
materials
tissues,
impressive
sealing
performance.
Язык: Английский
Bimetallic Catalysts Based on Chiral Amplification, Inversion, and Assembly for an Asymmetric Cascade Process
Опубликована: Апрель 8, 2025
Abstract
Designing
heterogeneous
catalysts
to
mimic
complicated
biological
processes
and
exploring
methods
precisely
modulate
their
chirality
is
crucial
for
asymmetric
reactions.
In
this
study,
two
chiral
were
immobilized
on
the
non-helical
C-C
polymers,
achieving
amplification
reversible
reversal
of
polymer
by
altering
copolymer
structure
solvent.
Additionally,
undergoes
a
layered
assembly
process
with
solvent
changes,
resulting
in
regulation
its
superhelical
fiber
(P
or
M
configuration).
At
high
concentrations,
it
aggregates
form
knitting
wool
ball-like
hyperhelical
three-dimensional
structure.
A
strong
correlation
has
been
established
between
catalytic
selectivity
catalyst
decarboxylative
Mannich
reaction/asymmetric
transfer
hydrogenation
enantioselective
cascade
reaction.
This
bimetallic
produces
products
reactions
activity
excellent
enantioselectivity,
"one
stone,
birds"
effect.
It
can
be
reused
10
times
without
significant
losss
stereoselectivity.
copolymerization
synthesis
strategy
may
contribute
development
new
controllable
Язык: Английский
Facile Preparation of Crosslinked PEG‐Polypeptide Drug Nanocarriers Through Biphasic Polymerization of Crude N‐Carboxyanhydrides
Macromolecular Bioscience,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 11, 2025
Abstract
Poly(ethylene
glycol)
(PEG)‐polypeptide
drug
nanocarriers
have
garnered
increasing
attention
during
last
decades.
However,
the
tedious
polymer
synthesis
and
stability
issue
greatly
limit
their
further
development.
Herein
biphasic
polymerization
platform
is
reported
for
easy
access
of
a
series
crosslinked
PEG‐polypeptide
nanoparticles
enhanced
loading
selective
release.
The
accelerated
allows
preparation
library
PEG‐polypeptides
from
crude
monomers
with
different
polypeptide
segments
structural
optimization.
Nanocarriers
redox‐responsive
de‐crosslinking
are
therefore
obtained
based
on
model
drug,
doxorubicin,
which
exhibits
killing
cancer
cells.
This
study
provides
synthetic
method
efficient
nanocarriers,
benefiting
downstream
therapeutic
studies.
Язык: Английский
ROPISA Strategy for In‐Situ Loading in Polypeptide Nanoparticles
Chemistry - An Asian Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 28, 2025
Abstract
We
report
a
ring‐opening
polymerization
induced
self‐assembly
(ROPISA)
synthetic
strategy
for
in‐situ
encapsulation
of
fluorescent
dye
molecules
in
poly(ʟ‐serine)
based
polypeptide
nano‐assemblies
and
demonstrate
their
cellular
bioimaging
application.
A
bulky
ʟ‐serine
N‐carboxyanhydride
monomer
is
tailor‐made
polymerized
using
PEG‐amine
as
hydrophilic
macroinitiator
water
at
pH
8.5
to
obtain
block
copolymer
stable
dispersions
the
form
opalescent
solutions.
Both
soluble
dyes
like
Rhodamine
B,
HPTS
insoluble
Nile
red
are
readily
encapsulated
ROPISA
process
which
afforded
nanoformulation
direct
application
biological
system.
The
nanoparticle
dispersion
found
be
stable,
they
have
spherical
morphology
25
nm
size.
nascent
nanoparticles
were
nontoxic
mammalian
cells
up
100
µg/mL
non‐hemolytic
Red
Blood
Cells.
These
endocytosed
across
cell
membrane
internalized
cytosol,
proof‐of‐concept
was
established
by
confocal
microscopy.
This
newly
developed
loading
opens
new
platform
nano‐formulations
both
material
biomedical
fields.
Язык: Английский