Emerging combination strategies with phototherapy in cancer nanomedicine

Chemical Society Reviews, Год журнала: 2020, Номер 49(22), С. 8065 - 8087

Опубликована: Янв. 1, 2020

Based on the challenges in single-mode phototherapy, this review summarizes significant research progress combinatorial strategies with phototherapy.

Язык: Английский

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Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials

Chemical Reviews, Год журнала: 2020, Номер 120(24), С. 13135 - 13272

Опубликована: Окт. 30, 2020

Photoactivatable (alternatively, photoremovable, photoreleasable, or photocleavable) protecting groups (PPGs), also known as caged photocaged compounds, are used to enable non-invasive spatiotemporal photochemical control over the release of species interest. Recent years have seen development PPGs activatable by biologically and chemically benign visible near-infrared (NIR) light. These long-wavelength-absorbing moieties expand applicability this powerful method its accessibility non-specialist users. This review comprehensively covers organic transition metal-containing photoactivatable compounds (complexes) that absorb in visible- NIR-range various leaving gasotransmitters (carbon monoxide, nitric oxide, hydrogen sulfide). The text NIR-light-induced photosensitized using molecular sensitizers, quantum dots, upconversion second-harmonic nanoparticles, well via photodynamic (photooxygenation singlet oxygen) photothermal effects. Release from polymers, micelles, vesicles, photoswitches, along with related emerging field photopharmacology, is discussed at end review.

Язык: Английский

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2D vanadium carbide MXenzyme to alleviate ROS-mediated inflammatory and neurodegenerative diseases

Nature Communications, Год журнала: 2021, Номер 12(1)

Опубликована: Апрель 13, 2021

Reactive oxygen species (ROS) are generated and consumed in living organism for normal metabolism. Paradoxically, the overproduction and/or mismanagement of ROS have been involved pathogenesis progression various human diseases. Here, we reported a two-dimensional (2D) vanadium carbide (V2C) MXene nanoenzyme (MXenzyme) that can mimic up to six naturally-occurring enzymes, including superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), glutathione (GPx), thiol (TPx) haloperoxidase (HPO). Based on these enzyme-mimicking properties, constructed 2D V2C MXenzyme not only possesses high biocompatibility but also exhibits robust vitro cytoprotection against oxidative stress. Importantly, rebuilds redox homeostasis without perturbing endogenous antioxidant status relieves ROS-induced damage with benign vivo therapeutic effects, as demonstrated both inflammation neurodegeneration animal models. These findings open an avenue enable use remedial nanoplatform treat ROS-mediated inflammatory neurodegenerative

Язык: Английский

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Overcoming barriers in photodynamic therapy harnessing nano-formulation strategies

Chemical Society Reviews, Год журнала: 2021, Номер 50(16), С. 9152 - 9201

Опубликована: Янв. 1, 2021

Photodynamic therapy (PDT) has been extensively investigated for decades tumor treatment because of its non-invasiveness, spatiotemporal selectivity, lower side-effects, and immune activation ability.

Язык: Английский

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Semiconducting Polymer Nanomaterials as Near-Infrared Photoactivatable Protherapeutics for Cancer

Accounts of Chemical Research, Год журнала: 2020, Номер 53(4), С. 752 - 762

Опубликована: Фев. 6, 2020

Cancer therapy is routinely performed in the clinic to cure cancer and control its progression, wherein therapeutic agents are generally used. To reduce side effects, protherapeutic that can be activated by overexpressed biomarkers under development. However, these still face certain extent of off-target activation normal tissues, stimulating interest design external-stimuli activatable protherapeutics. In this regard, photoactivatable have been utilized for treatments. because intrinsic features photolabile moieties, most only respond ultraviolet-visible light, limiting their vivo applications. Thus, near-infrared (NIR) light with minimal phototoxicity increased tissue penetration highly desired.In Account, we summarize our semiconducting polymer nanomaterials (SPNs) as NIR treatment. SPNs transformed from π-conjugated polymers efficiently convert into heat or singlet oxygen (1O2). With photothermal photodynamic properties, directly used photomedicine serve transducers activate 1O2-responsive agents.The heat-activatable SPN-based developed loading conjugating (e.g., agonist, gene, enzyme). For instance, photothermally triggered release agonists specifically activates protein ion channels on cellular membrane, leading overinflux induced mitochondria dysfunction consequently apoptosis cells. Moreover, temperature-sensitive bromelain promote situ degradation collagens (the major components extracellular matrix), resulting an improved accumulation tumor tissues thus amplified outcome.The 1O2-activatable constructed through covalent conjugation caged via hypoxia- 1O2-cleavable linkers. Upon photoirradiation, consume generate 1O2, which leads (PDT), meanwhile breaks linkers on-demand molecules chemodrug, enzyme, inhibitor). Such remote applied induce DNA damage, ribonucleic acid degradation, inhibition biosynthesis, immune system tumors living animals. By synergizing PDT photoactivation those biological actions, effectively eliminate even fully inhibit metastasis.This Account highlights potential construction versatile protherapeutics treat at designated times locations high outcome precision.

Язык: Английский

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High-Performance Self-Cascade Pyrite Nanozymes for Apoptosis–Ferroptosis Synergistic Tumor Therapy

ACS Nano, Год журнала: 2021, Номер 15(3), С. 5735 - 5751

Опубликована: Март 11, 2021

As next-generation artificial enzymes, nanozymes have shown great promise for tumor catalytic therapy. In particular, their peroxidase-like activity has been employed to catalyze hydrogen peroxide (H2O2) produce highly toxic hydroxyl radicals (•OH) kill cells. However, limited by the low affinity between with H2O2 and level of in microenvironment, peroxidase usually produced insufficient •OH cells therapeutic purposes. Herein, we present a pyrite nanozyme ultrahigh affinity, resulting 4144- 3086-fold increase compared that classical Fe3O4 natural horseradish peroxidase, respectively. We found also possesses intrinsic glutathione oxidase-like activity, which catalyzes oxidation reduced accompanied generation. Thus, dual-activity constitutes self-cascade platform generate abundant deplete glutathione, induces apoptosis as well ferroptosis Consequently, it killed apoptosis-resistant harboring KRAS mutation inducing ferroptosis. The exhibited favorable tumor-specific cytotoxicity biodegradability ensure its biosafety. These results indicate high-performance is an effective reagent may aid development nanozyme-based

Язык: Английский

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Organic Semiconducting Pro‐nanostimulants for Near‐Infrared Photoactivatable Cancer Immunotherapy

Angewandte Chemie International Edition, Год журнала: 2019, Номер 58(36), С. 12680 - 12687

Опубликована: Июль 6, 2019

Abstract In this study, an organic semiconducting pro‐nanostimulant (OSPS) with a near‐infrared (NIR) photoactivatable immunotherapeutic action for synergetic cancer therapy is presented. OSPS comprises polymer nanoparticle (SPN) core and immunostimulant conjugated through singlet oxygen ( 1 O 2 ) cleavable linkers. Upon NIR laser irradiation, generates both heat to exert combinational phototherapy not only ablate tumors but also produce tumor‐associated antigens. More importantly, irradiation triggers the cleavage of ‐cleavable linkers, triggering remote release immunostimulants from modulate immunosuppressive tumor microenvironment. Thus, released antigens in conjunction activated induce synergistic antitumor immune response after OSPS‐mediated phototherapy, resulting inhibited growth primary/distant lung metastasis mouse xenograft model, which observed sole phototherapy.

Язык: Английский

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Second Near‐Infrared Photothermal Semiconducting Polymer Nanoadjuvant for Enhanced Cancer Immunotherapy

Advanced Materials, Год журнала: 2020, Номер 33(4)

Опубликована: Дек. 16, 2020

Abstract Immunotherapy has offered new treatment options for cancer; however, the therapeutic benefits are often modest and desired to be improved. A semiconducting polymer nanoadjuvant (SPN II R) with a photothermally triggered cargo release second near‐infrared (NIR‐II) photothermal immunotherapy is reported here. SPN R consists of nanoparticle core as an NIR‐II converter, which doped toll‐like receptor (TLR) agonist adjuvant coated thermally responsive lipid shell. Upon photoirradiation, effectively generates heat not only ablate tumors induce immunogenic cell death (ICD), but also melt layers on‐demand TLR agonist. The combination ICD activation TLR7/TLR8 enhances maturation dendritic cells, amplifies anti‐tumor immune responses. Thus, single R‐mediated inhibits growth both primary distant eliminates lung metastasis in murine mouse model. This study thus provides remote‐controlled smart delivery system synergize photomedicine enhanced cancer treatment.

Язык: Английский

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Near-infrared photoactivated nanomedicines for photothermal synergistic cancer therapy

Nano Today, Год журнала: 2021, Номер 37, С. 101073 - 101073

Опубликована: Янв. 10, 2021

Язык: Английский

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Molecular and nanoengineering approaches towards activatable cancer immunotherapy

Chemical Society Reviews, Год журнала: 2020, Номер 49(13), С. 4234 - 4253

Опубликована: Янв. 1, 2020

This review summarizes the development of activatable immunotherapeutic nanoagents that activate antitumor immunity only in response to internal or external stimuli, which potentially enhance patient rates while reducing immune-related adverse events during cancer immunotherapy.

Язык: Английский

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