Advanced Materials,
Journal Year:
2019,
Volume and Issue:
31(46)
Published: Sept. 30, 2019
Inhibition
of
protein
biosynthesis
is
a
promising
strategy
to
develop
new
therapeutic
modalities
for
cancers;
however,
noninvasive
precise
regulation
this
cellular
event
in
living
systems
has
been
rarely
reported.
In
study,
semiconducting
polymer
nanoblockader
(SPNB
)
developed
that
can
inhibit
intracellular
synthesis
upon
near-infrared
(NIR)
photoactivation
synergize
with
photodynamic
therapy
(PDT)
metastasis-inhibited
cancer
therapy.
SPNB
self-assembled
from
an
amphiphilic
which
grafted
poly(ethylene
glycol)
conjugated
blockader
through
singlet
oxygen
(1
O2
cleavable
linker.
Such
designed
molecular
structure
not
only
enables
generation
1
under
NIR
photoirradiation
PDT,
but
also
permits
blockaders
terminate
translation.
Thereby,
exerts
synergistic
action
afford
enhanced
efficacy
tumor
ablation.
More
importantly,
-mediated
inhibition
precisely
and
remotely
downregulates
the
expression
levels
metastasis-related
proteins
tissues,
eventually
contributing
complete
lung
metastasis.
This
study
thus
proposes
photoactivatable
protherapeutic
design
Chemical Reviews,
Journal Year:
2020,
Volume and Issue:
120(24), P. 13135 - 13272
Published: Oct. 30, 2020
Photoactivatable
(alternatively,
photoremovable,
photoreleasable,
or
photocleavable)
protecting
groups
(PPGs),
also
known
as
caged
photocaged
compounds,
are
used
to
enable
non-invasive
spatiotemporal
photochemical
control
over
the
release
of
species
interest.
Recent
years
have
seen
development
PPGs
activatable
by
biologically
and
chemically
benign
visible
near-infrared
(NIR)
light.
These
long-wavelength-absorbing
moieties
expand
applicability
this
powerful
method
its
accessibility
non-specialist
users.
This
review
comprehensively
covers
organic
transition
metal-containing
photoactivatable
compounds
(complexes)
that
absorb
in
visible-
NIR-range
various
leaving
gasotransmitters
(carbon
monoxide,
nitric
oxide,
hydrogen
sulfide).
The
text
NIR-light-induced
photosensitized
using
molecular
sensitizers,
quantum
dots,
upconversion
second-harmonic
nanoparticles,
well
via
photodynamic
(photooxygenation
singlet
oxygen)
photothermal
effects.
Release
from
polymers,
micelles,
vesicles,
photoswitches,
along
with
related
emerging
field
photopharmacology,
is
discussed
at
end
review.
Chemical Society Reviews,
Journal Year:
2021,
Volume and Issue:
50(16), P. 9152 - 9201
Published: Jan. 1, 2021
Photodynamic
therapy
(PDT)
has
been
extensively
investigated
for
decades
tumor
treatment
because
of
its
non-invasiveness,
spatiotemporal
selectivity,
lower
side-effects,
and
immune
activation
ability.
Nature Communications,
Journal Year:
2021,
Volume and Issue:
12(1)
Published: April 13, 2021
Reactive
oxygen
species
(ROS)
are
generated
and
consumed
in
living
organism
for
normal
metabolism.
Paradoxically,
the
overproduction
and/or
mismanagement
of
ROS
have
been
involved
pathogenesis
progression
various
human
diseases.
Here,
we
reported
a
two-dimensional
(2D)
vanadium
carbide
(V2C)
MXene
nanoenzyme
(MXenzyme)
that
can
mimic
up
to
six
naturally-occurring
enzymes,
including
superoxide
dismutase
(SOD),
catalase
(CAT),
peroxidase
(POD),
glutathione
(GPx),
thiol
(TPx)
haloperoxidase
(HPO).
Based
on
these
enzyme-mimicking
properties,
constructed
2D
V2C
MXenzyme
not
only
possesses
high
biocompatibility
but
also
exhibits
robust
vitro
cytoprotection
against
oxidative
stress.
Importantly,
rebuilds
redox
homeostasis
without
perturbing
endogenous
antioxidant
status
relieves
ROS-induced
damage
with
benign
vivo
therapeutic
effects,
as
demonstrated
both
inflammation
neurodegeneration
animal
models.
These
findings
open
an
avenue
enable
use
remedial
nanoplatform
treat
ROS-mediated
inflammatory
neurodegenerative
Accounts of Chemical Research,
Journal Year:
2020,
Volume and Issue:
53(4), P. 752 - 762
Published: Feb. 6, 2020
Cancer
therapy
is
routinely
performed
in
the
clinic
to
cure
cancer
and
control
its
progression,
wherein
therapeutic
agents
are
generally
used.
To
reduce
side
effects,
protherapeutic
that
can
be
activated
by
overexpressed
biomarkers
under
development.
However,
these
still
face
certain
extent
of
off-target
activation
normal
tissues,
stimulating
interest
design
external-stimuli
activatable
protherapeutics.
In
this
regard,
photoactivatable
have
been
utilized
for
treatments.
because
intrinsic
features
photolabile
moieties,
most
only
respond
ultraviolet-visible
light,
limiting
their
vivo
applications.
Thus,
near-infrared
(NIR)
light
with
minimal
phototoxicity
increased
tissue
penetration
highly
desired.In
Account,
we
summarize
our
semiconducting
polymer
nanomaterials
(SPNs)
as
NIR
treatment.
SPNs
transformed
from
π-conjugated
polymers
efficiently
convert
into
heat
or
singlet
oxygen
(1O2).
With
photothermal
photodynamic
properties,
directly
used
photomedicine
serve
transducers
activate
1O2-responsive
agents.The
heat-activatable
SPN-based
developed
loading
conjugating
(e.g.,
agonist,
gene,
enzyme).
For
instance,
photothermally
triggered
release
agonists
specifically
activates
protein
ion
channels
on
cellular
membrane,
leading
overinflux
induced
mitochondria
dysfunction
consequently
apoptosis
cells.
Moreover,
temperature-sensitive
bromelain
promote
situ
degradation
collagens
(the
major
components
extracellular
matrix),
resulting
an
improved
accumulation
tumor
tissues
thus
amplified
outcome.The
1O2-activatable
constructed
through
covalent
conjugation
caged
via
hypoxia-
1O2-cleavable
linkers.
Upon
photoirradiation,
consume
generate
1O2,
which
leads
(PDT),
meanwhile
breaks
linkers
on-demand
molecules
chemodrug,
enzyme,
inhibitor).
Such
remote
applied
induce
DNA
damage,
ribonucleic
acid
degradation,
inhibition
biosynthesis,
immune
system
tumors
living
animals.
By
synergizing
PDT
photoactivation
those
biological
actions,
effectively
eliminate
even
fully
inhibit
metastasis.This
Account
highlights
potential
construction
versatile
protherapeutics
treat
at
designated
times
locations
high
outcome
precision.
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(3), P. 5735 - 5751
Published: March 11, 2021
As
next-generation
artificial
enzymes,
nanozymes
have
shown
great
promise
for
tumor
catalytic
therapy.
In
particular,
their
peroxidase-like
activity
has
been
employed
to
catalyze
hydrogen
peroxide
(H2O2)
produce
highly
toxic
hydroxyl
radicals
(•OH)
kill
cells.
However,
limited
by
the
low
affinity
between
with
H2O2
and
level
of
in
microenvironment,
peroxidase
usually
produced
insufficient
•OH
cells
therapeutic
purposes.
Herein,
we
present
a
pyrite
nanozyme
ultrahigh
affinity,
resulting
4144-
3086-fold
increase
compared
that
classical
Fe3O4
natural
horseradish
peroxidase,
respectively.
We
found
also
possesses
intrinsic
glutathione
oxidase-like
activity,
which
catalyzes
oxidation
reduced
accompanied
generation.
Thus,
dual-activity
constitutes
self-cascade
platform
generate
abundant
deplete
glutathione,
induces
apoptosis
as
well
ferroptosis
Consequently,
it
killed
apoptosis-resistant
harboring
KRAS
mutation
inducing
ferroptosis.
The
exhibited
favorable
tumor-specific
cytotoxicity
biodegradability
ensure
its
biosafety.
These
results
indicate
high-performance
is
an
effective
reagent
may
aid
development
nanozyme-based
Angewandte Chemie International Edition,
Journal Year:
2019,
Volume and Issue:
58(36), P. 12680 - 12687
Published: July 6, 2019
Abstract
In
this
study,
an
organic
semiconducting
pro‐nanostimulant
(OSPS)
with
a
near‐infrared
(NIR)
photoactivatable
immunotherapeutic
action
for
synergetic
cancer
therapy
is
presented.
OSPS
comprises
polymer
nanoparticle
(SPN)
core
and
immunostimulant
conjugated
through
singlet
oxygen
(
1
O
2
)
cleavable
linkers.
Upon
NIR
laser
irradiation,
generates
both
heat
to
exert
combinational
phototherapy
not
only
ablate
tumors
but
also
produce
tumor‐associated
antigens.
More
importantly,
irradiation
triggers
the
cleavage
of
‐cleavable
linkers,
triggering
remote
release
immunostimulants
from
modulate
immunosuppressive
tumor
microenvironment.
Thus,
released
antigens
in
conjunction
activated
induce
synergistic
antitumor
immune
response
after
OSPS‐mediated
phototherapy,
resulting
inhibited
growth
primary/distant
lung
metastasis
mouse
xenograft
model,
which
observed
sole
phototherapy.
Advanced Materials,
Journal Year:
2020,
Volume and Issue:
33(4)
Published: Dec. 16, 2020
Abstract
Immunotherapy
has
offered
new
treatment
options
for
cancer;
however,
the
therapeutic
benefits
are
often
modest
and
desired
to
be
improved.
A
semiconducting
polymer
nanoadjuvant
(SPN
II
R)
with
a
photothermally
triggered
cargo
release
second
near‐infrared
(NIR‐II)
photothermal
immunotherapy
is
reported
here.
SPN
R
consists
of
nanoparticle
core
as
an
NIR‐II
converter,
which
doped
toll‐like
receptor
(TLR)
agonist
adjuvant
coated
thermally
responsive
lipid
shell.
Upon
photoirradiation,
effectively
generates
heat
not
only
ablate
tumors
induce
immunogenic
cell
death
(ICD),
but
also
melt
layers
on‐demand
TLR
agonist.
The
combination
ICD
activation
TLR7/TLR8
enhances
maturation
dendritic
cells,
amplifies
anti‐tumor
immune
responses.
Thus,
single
R‐mediated
inhibits
growth
both
primary
distant
eliminates
lung
metastasis
in
murine
mouse
model.
This
study
thus
provides
remote‐controlled
smart
delivery
system
synergize
photomedicine
enhanced
cancer
treatment.
Chemical Society Reviews,
Journal Year:
2020,
Volume and Issue:
49(13), P. 4234 - 4253
Published: Jan. 1, 2020
This
review
summarizes
the
development
of
activatable
immunotherapeutic
nanoagents
that
activate
antitumor
immunity
only
in
response
to
internal
or
external
stimuli,
which
potentially
enhance
patient
rates
while
reducing
immune-related
adverse
events
during
cancer
immunotherapy.
