Therapeutic Potential of Natural Compounds Acting through Epigenetic Mechanisms in Cardiovascular Diseases: Current Findings and Future Directions

Nutrients, Год журнала: 2024, Номер 16(15), С. 2399 - 2399

Опубликована: Июль 24, 2024

Cardiovascular diseases (CVDs) remain a leading global cause of morbidity and mortality. These have multifaceted nature being influenced by multitude biochemical, genetic, environmental, behavioral factors. Epigenetic modifications crucial role in the onset progression CVD. Epigenetics, which regulates gene activity without altering DNA’s primary structure, can modulate cardiovascular homeostasis through DNA methylation, histone modification, non-coding RNA regulation. The effects environmental stimuli on CVD are mediated epigenetic changes, be reversible and, hence, susceptible to pharmacological interventions. This represents an opportunity prevent targeting harmful modifications. Factors such as high-fat diets or nutrient deficiencies influence enzymes, affecting fetal growth, metabolism, oxidative stress, inflammation, atherosclerosis. Recent studies shown that plant-derived bioactive compounds regulators inflammatory responses, contributing cardioprotective diets. Understanding these nutriepigenetic their reversibility is for developing effective interventions combat review delves into general mechanisms epigenetics, its regulatory roles CVD, potential epigenetics therapeutic strategy. It also examines natural (ENCs) intervention tools prevention therapy.

Язык: Английский

---

The emerging role of microRNAs in bone remodeling and its therapeutic implications for osteoporosis

Bioscience Reports, Год журнала: 2018, Номер 38(3)

Опубликована: Май 30, 2018

Osteoporosis, a common and multifactorial disease, is influenced by genetic factors environments. However, the pathogenesis of osteoporosis has not been fully elucidated yet. Recently, emerging evidence suggests that epigenetic modifications may be underlying mechanisms link environmental with increased risks bone fracture. MicroRNA (miRNA), major category small noncoding RNA 20–22 bases in length, recognized as one important modification. It can mediate post-transcriptional regulation target genes cell differentiation apoptosis. In this review, we aimed to profile role miRNA remodeling its therapeutic implications for osteoporosis. A deeper insight into provide unique opportunities develop novel diagnostic approach

Язык: Английский

---

Roles of CircRNAs in Autoimmune Diseases

Frontiers in Immunology, Год журнала: 2019, Номер 10

Опубликована: Апрель 2, 2019

Circular RNAs (circRNAs) are covalently linked single-stranded RNAs, compared to linear counterparts, that relatively abundant, conserved, stable and specific. Previously, most studies have revealed circRNAs function in gene expression processes participate the pathogenesis of cancers, cardiovascular diseases neurological diseases. With advances biotechnology, more biological functions been found several signaling pathways related tumorigenesis, immunity metabolism. Recently, many reported be expressed abnormally play important roles progression autoimmune Thus, may not only serve as potential biomarkers but also act immune regulators offer opportunities for therapy. This review briefly introduces properties well different stages expression. In addition, this article summarizes available knowledge about discusses their these diseases, which helps us understand regulatory mechanisms provides future research perspectives.

Язык: Английский

---

Circulating exosomal miRNAs in cardiovascular disease pathogenesis: New emerging hopes

Journal of Cellular Physiology, Год журнала: 2019, Номер 234(12), С. 21796 - 21809

Опубликована: Июль 5, 2019

Abstract Cardiovascular diseases (CVDs) are one of the leading causes morbidity and mortality. Standard therapies have failed to significantly increase patients’ survival. Moreover, majority conventional screening procedures ineffective for diagnosis CVDs at early stages. Accumulating evidence suggests that numerous cell types release a class nano‐sized vesicles named exosomes into extracellular space. Exosomes widely distributed in various body fluids contain number diverse biomolecules such as proteins, lipids, both mRNA noncoding RNAs which reflect host‐cell molecular architecture. MicroRNAs (miRNAs), can be found exosomes, could taken up by neighboring distal cells. Not only has recent indicated regulatory role exosomal miRNAs pathogenesis CVD, but it also been shown differential expression made them promising biomarkers detection CVDs. Owing these remarkable features, emerged hot spots research. This review summarizes discusses their potential application clinical setting therapeutic diagnostic tools.

Язык: Английский

---

KCNQ1OT1, HIF1A‐AS2 and APOA1‐AS are promising novel biomarkers for diagnosis of coronary artery disease

Clinical and Experimental Pharmacology and Physiology, Год журнала: 2019, Номер 46(7), С. 635 - 642

Опубликована: Апрель 3, 2019

Abstract This study aimed to evaluate the potential of long noncoding RNA s (lnc s) as biomarkers for coronary artery disease ( CAD ). We measured levels three atherosclerosis‐ or cardiac‐related lnc in peripheral blood monocyte cells PBMC from 20 patients and non‐ control participants using real‐time reverse transcription–polymerase chain reaction (real‐time RT – PCR ) methods. found that KCNQ 1 opposite strand/antisense transcript OT 1), hypoxia‐inducible factor alpha‐antisense 2 HIF 1A‐ AS 2) apolipoprotein A‐1 antisense APOA 1‐ were significantly increased by 2.38‐fold, P = 0.00042; 2.00‐fold, 0.0001; 4.52‐fold, 0.000048). The area under ROC curve was 0.865 1, 0.852 2, 0.967 . Furthermore, combination resulted a much higher AUC value 0.990 prediction Spearman's correlation analysis showed positively correlated with NT ‐pro BNP , CKMB MYO HsTnT, whereas HsTnT. Hence, elevation predicts these molecules may be considered novel

Язык: Английский

---

MicroRNAs and Long Non-coding RNAs in Genetic Diseases

Molecular Diagnosis & Therapy, Год журнала: 2019, Номер 23(2), С. 155 - 171

Опубликована: Янв. 4, 2019

Since the discovery and classification of non-coding RNAs, their roles have gained great attention. In this respect, microRNAs long RNAs been firmly demonstrated to be linked regulation gene expression onset human diseases, including rare genetic diseases; therefore they are suitable targets for therapeutic intervention. This issue, in context is being considered by an increasing number research groups key interest health community. case possibility developing personalized therapy precision medicine has attracted attention researchers clinicians involved "orphan medicinal products" proposing these European Medicines Agency (EMA) Food Drug Administration (FDA) Office Orphan Products Development (OOPD) United States. The major focuses activities evaluation development products (drugs, biologics, devices, or medical foods) promising diagnosis and/or treatment diseases conditions, diseases. analysis proven a strategy. These include, but not limited to, Duchenne muscular dystrophy, cystic fibrosis, Rett syndrome, β-thalassemia. conclusion, large approaches based on targeting expected field molecular therapy, with facilitated technological transfer virtue existing concerning

Язык: Английский

---

Emerging roles of circRNAs in the pathological process of myocardial infarction

Molecular Therapy — Nucleic Acids, Год журнала: 2021, Номер 26, С. 828 - 848

Опубликована: Окт. 9, 2021

Myocardial infarction (MI) is defined as cardiomyocyte death in a clinical context consistent with ischemic insult. MI remains one of the leading causes morbidity and mortality worldwide. Although there are number effective methods for diagnosis treatment MI, further investigation novel biomarkers molecular therapeutic targets required. Circular RNAs (circRNAs), non-coding RNAs, have been reported to function mainly by acting microRNA (miRNA) sponges or binding RNA-binding proteins (RBPs). The circRNA-miRNA-mRNA (protein) regulatory pathway regulates gene expression affects pathological mechanisms various diseases. Undoubtedly, more comprehensive understanding relationship between circRNA will lay foundation development circRNA-based diagnostic strategies MI. Therefore, this review summarizes pathophysiological process approaches measure levels patients, tissues, cells; highlights significance circRNAs regulation pathogenesis development; provides potential insight diagnosis, prognosis,

Язык: Английский

---

Nanodiagnosis and Nanotreatment of Cardiovascular Diseases: An Overview

Chemosensors, Год журнала: 2021, Номер 9(4), С. 67 - 67

Опубликована: Март 30, 2021

Cardiovascular diseases (CVDs) are the world’s leading cause of mortality and represent a large contributor to costs medical care. Although tremendous progress has been made for diagnosis CVDs, there is an important need more effective early design novel diagnostic methods. The CVDs generally relies on signs symptoms depending molecular imaging (MI) or CVD-associated biomarkers. For early-stage however, reliability, specificity, accuracy analysis still problematic. Because their unique chemical physical properties, nanomaterial systems have recognized as potential candidates enhance functional use instruments. Nanomaterials such gold nanoparticles, carbon nanotubes, quantum dots, lipids, polymeric nanoparticles sources target CVDs. special properties nanomaterials including surface energy topographies actively cellular response within availability newly advanced techniques in science opens new avenues targeting successful application needs detailed understanding both disease moieties.

Язык: Английский

---

Epigenetics-based therapeutics for myocardial fibrosis

Life Sciences, Год журнала: 2021, Номер 271, С. 119186 - 119186

Опубликована: Фев. 9, 2021

Язык: Английский

---

circCELF1 Inhibits Myocardial Fibrosis by Regulating the Expression of DKK2 Through FTO/m6A and miR-636

Journal of Cardiovascular Translational Research, Год журнала: 2022, Номер 15(5), С. 998 - 1009

Опубликована: Фев. 7, 2022

Язык: Английский

---