Regulation of Stem Cell Aging by Metabolism and Epigenetics

Cell Metabolism, Год журнала: 2017, Номер 26(3), С. 460 - 474

Опубликована: Авг. 17, 2017

Язык: Английский

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The Mouse Microbiome Is Required for Sex-Specific Diurnal Rhythms of Gene Expression and Metabolism

Cell Metabolism, Год журнала: 2018, Номер 29(2), С. 362 - 382.e8

Опубликована: Окт. 18, 2018

The circadian clock and associated feeding rhythms have a profound impact on metabolism the gut microbiome. To what extent microbiota reciprocally affect daily of physiology in host remains elusive. Here, we analyzed transcriptome metabolome profiles male female germ-free mice. While mRNA expression genes revealed subtle changes liver, intestine, white adipose tissue, mice showed considerably altered with rhythmic physiology. Strikingly, absence microbiome attenuated liver sexual dimorphism sex-specific rhythmicity. resulting feminization masculinization animals is likely caused by development growth hormone secretion, differential activation xenobiotic receptors. This defines novel mechanism which regulates metabolism.

Язык: Английский

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The Gut Microbiota at the Service of Immunometabolism

Cell Metabolism, Год журнала: 2020, Номер 32(4), С. 514 - 523

Опубликована: Сен. 17, 2020

Язык: Английский

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Lipid metabolism and lipid signals in aging and longevity

Developmental Cell, Год журнала: 2021, Номер 56(10), С. 1394 - 1407

Опубликована: Апрель 22, 2021

Язык: Английский

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Causal roles of mitochondrial dynamics in longevity and healthy aging

EMBO Reports, Год журнала: 2019, Номер 20(12)

Опубликована: Окт. 31, 2019

Язык: Английский

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Bacterial Quorum-Sensing Systems and Their Role in Intestinal Bacteria-Host Crosstalk

Frontiers in Microbiology, Год журнала: 2021, Номер 12

Опубликована: Янв. 28, 2021

Quorum-sensing (QS) system is a rapidly developing field in which we are gradually expanding our understanding about how bacteria communicate with each other and regulate their activities bacterial sociality. In addition to collectively modifying behavior, QS-related autoinducers may also be embedded the crosstalk between host parasitic microbes. this review, summarize current studies on QS intestinal microbiome its potential role maintaining homeostasis under physiological conditions. Additionally, outline canonical related signal-response systems by several pathogens interact pathological conditions, goal of better sociality facilitating novel antimicrobial therapeutic strategies.

Язык: Английский

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It is the time for quorum sensing inhibition as alternative strategy of antimicrobial therapy

Cell Communication and Signaling, Год журнала: 2023, Номер 21(1)

Опубликована: Июнь 14, 2023

Abstract Multiple drug resistance poses a significant threat to public health worldwide, with substantial increase in morbidity and mortality rates. Consequently, searching for novel strategies control microbial pathogenicity is necessary. With the aid of auto-inducers (AIs), quorum sensing (QS) regulates bacterial virulence factors through cell-to-cell signaling networks. AIs are small molecules produced during stationary phase. When cultures reach certain level growth, these regulate expression bound genes by acting as mirrors that reflect inoculum density. Gram-positive bacteria use peptide derivatives molecules, whereas Gram-negative fatty acid derivatives, majority can both types modulate target gene. Numerous natural synthetic QS inhibitors (QSIs) have been developed reduce pathogenesis. Applications QSI vital human health, well fisheries aquaculture, agriculture, water treatment.

Язык: Английский

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Crosstalk between the microbiome and epigenome: messages from bugs

The Journal of Biochemistry, Год журнала: 2017, Номер 163(2), С. 105 - 112

Опубликована: Ноя. 16, 2017

Mammals exist in a complicated symbiotic relationship with their gut microbiome, which is postulated to have broad impacts on host health and disease. As omics-based technologies matured, the potential mechanisms by microbiome affects physiology are being addressed. The provides environmental cues, can modify cell responses stimuli through alterations epigenome and, ultimately, gene expression. Increasing evidence highlights microbial generation of bioactive compounds that impact transcriptional machinery cells. Here, we review current understanding crosstalk between microbiota epigenome, including DNA methylation, histone modification non-coding RNAs. These studies providing insights into how responds signalling predicted provide information for application precision medicine.

Язык: Английский

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Lysosomal Signaling Promotes Longevity by Adjusting Mitochondrial Activity

Developmental Cell, Год журнала: 2019, Номер 48(5), С. 685 - 696.e5

Опубликована: Янв. 31, 2019

Язык: Английский

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Olfactory specificity regulates lipid metabolism through neuroendocrine signaling in Caenorhabditis elegans

Nature Communications, Год журнала: 2020, Номер 11(1)

Опубликована: Март 19, 2020

Abstract Olfactory and metabolic dysfunctions are intertwined phenomena associated with obesity neurodegenerative diseases; yet how mechanistically olfaction regulates homeostasis remains unclear. Specificity of olfactory perception integrates diverse environmental odors neurons expressing different receptors. Here, we report that specific but not all actively regulate fat metabolism without affecting eating behaviors in Caenorhabditis elegans , identified reduce mobilization via inhibiting these neurons. Optogenetic activation or inhibition the responsible neural circuit promotes loss gain storage, respectively. Furthermore, discovered FLP-1 neuropeptide released from this signals through peripheral NPR-4/neuropeptide receptor, SGK-1/serum- glucocorticoid-inducible kinase, isoforms DAF-16/FOXO transcription factor to storage. Our work reveals molecular mechanisms underlying regulation metabolism, suggests association between specificity each individual his/her susceptibility development obesity.

Язык: Английский

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