Cross talk between the liver microbiome and epigenome in patients with metabolic dysfunction-associated steatotic liver disease DOI Creative Commons
Carlos J. Pirola, Adrián Salatino, Tomas Fernández Gianotti

et al.

EBioMedicine, Journal Year: 2024, Volume and Issue: 101, P. 104996 - 104996

Published: Feb. 5, 2024

The pathogenesis of MASLD (metabolic dysfunction-associated steatotic liver disease), including its severe clinical forms, involves complex processes at all levels biological organization. This study examined the potential link between microbiome profile and epigenetic factors.

Language: Английский

Regulation of Stem Cell Aging by Metabolism and Epigenetics DOI Creative Commons
Ruotong Ren, Alejandro Ocampo, Guang‐Hui Liu

et al.

Cell Metabolism, Journal Year: 2017, Volume and Issue: 26(3), P. 460 - 474

Published: Aug. 17, 2017

Language: Английский

Citations

230
The Mouse Microbiome Is Required for Sex-Specific Diurnal Rhythms of Gene Expression and Metabolism DOI Creative Commons
Benjamin D. Weger, Cédric Gobet, Jake Yeung

et al.

Cell Metabolism, Journal Year: 2018, Volume and Issue: 29(2), P. 362 - 382.e8

Published: Oct. 18, 2018

The circadian clock and associated feeding rhythms have a profound impact on metabolism the gut microbiome. To what extent microbiota reciprocally affect daily of physiology in host remains elusive. Here, we analyzed transcriptome metabolome profiles male female germ-free mice. While mRNA expression genes revealed subtle changes liver, intestine, white adipose tissue, mice showed considerably altered with rhythmic physiology. Strikingly, absence microbiome attenuated liver sexual dimorphism sex-specific rhythmicity. resulting feminization masculinization animals is likely caused by development growth hormone secretion, differential activation xenobiotic receptors. This defines novel mechanism which regulates metabolism.

Language: Английский

Citations

228
The Gut Microbiota at the Service of Immunometabolism DOI Creative Commons
Chloé Michaudel, Harry Sokol

Cell Metabolism, Journal Year: 2020, Volume and Issue: 32(4), P. 514 - 523

Published: Sept. 17, 2020

Language: Английский

Citations

218
Lipid metabolism and lipid signals in aging and longevity DOI Creative Commons
Ayse Sena Mutlu,

Jonathon Duffy,

Meng C. Wang

et al.

Developmental Cell, Journal Year: 2021, Volume and Issue: 56(10), P. 1394 - 1407

Published: April 22, 2021

Language: Английский

Citations

175
Causal roles of mitochondrial dynamics in longevity and healthy aging DOI Open Access
Arpit Sharma, Hannah J. Smith,

Pallas Yao

et al.

EMBO Reports, Journal Year: 2019, Volume and Issue: 20(12)

Published: Oct. 31, 2019

Language: Английский

Citations

169
Bacterial Quorum-Sensing Systems and Their Role in Intestinal Bacteria-Host Crosstalk DOI Creative Commons
Liang Wu, Yubin Luo

Frontiers in Microbiology, Journal Year: 2021, Volume and Issue: 12

Published: Jan. 28, 2021

Quorum-sensing (QS) system is a rapidly developing field in which we are gradually expanding our understanding about how bacteria communicate with each other and regulate their activities bacterial sociality. In addition to collectively modifying behavior, QS-related autoinducers may also be embedded the crosstalk between host parasitic microbes. this review, summarize current studies on QS intestinal microbiome its potential role maintaining homeostasis under physiological conditions. Additionally, outline canonical related signal-response systems by several pathogens interact pathological conditions, goal of better sociality facilitating novel antimicrobial therapeutic strategies.

Language: Английский

Citations

113
It is the time for quorum sensing inhibition as alternative strategy of antimicrobial therapy DOI Creative Commons
Nourhan G. Naga, Dalia E. El-Badan, Khaled M. Ghanem

et al.

Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)

Published: June 14, 2023

Abstract Multiple drug resistance poses a significant threat to public health worldwide, with substantial increase in morbidity and mortality rates. Consequently, searching for novel strategies control microbial pathogenicity is necessary. With the aid of auto-inducers (AIs), quorum sensing (QS) regulates bacterial virulence factors through cell-to-cell signaling networks. AIs are small molecules produced during stationary phase. When cultures reach certain level growth, these regulate expression bound genes by acting as mirrors that reflect inoculum density. Gram-positive bacteria use peptide derivatives molecules, whereas Gram-negative fatty acid derivatives, majority can both types modulate target gene. Numerous natural synthetic QS inhibitors (QSIs) have been developed reduce pathogenesis. Applications QSI vital human health, well fisheries aquaculture, agriculture, water treatment.

Language: Английский

Citations

70
Crosstalk between the microbiome and epigenome: messages from bugs DOI Creative Commons
Yufeng Qin, Paul A. Wade

The Journal of Biochemistry, Journal Year: 2017, Volume and Issue: 163(2), P. 105 - 112

Published: Nov. 16, 2017

Mammals exist in a complicated symbiotic relationship with their gut microbiome, which is postulated to have broad impacts on host health and disease. As omics-based technologies matured, the potential mechanisms by microbiome affects physiology are being addressed. The provides environmental cues, can modify cell responses stimuli through alterations epigenome and, ultimately, gene expression. Increasing evidence highlights microbial generation of bioactive compounds that impact transcriptional machinery cells. Here, we review current understanding crosstalk between microbiota epigenome, including DNA methylation, histone modification non-coding RNAs. These studies providing insights into how responds signalling predicted provide information for application precision medicine.

Language: Английский

Citations

163
Lysosomal Signaling Promotes Longevity by Adjusting Mitochondrial Activity DOI Creative Commons
Prasanna Venkatesh Ramachandran,

Marzia Savini,

Andrew Folick

et al.

Developmental Cell, Journal Year: 2019, Volume and Issue: 48(5), P. 685 - 696.e5

Published: Jan. 31, 2019

Language: Английский

Citations

90
Olfactory specificity regulates lipid metabolism through neuroendocrine signaling in Caenorhabditis elegans DOI Creative Commons
Ayse Sena Mutlu, Shihong Max Gao, Haining Zhang

et al.

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: March 19, 2020

Abstract Olfactory and metabolic dysfunctions are intertwined phenomena associated with obesity neurodegenerative diseases; yet how mechanistically olfaction regulates homeostasis remains unclear. Specificity of olfactory perception integrates diverse environmental odors neurons expressing different receptors. Here, we report that specific but not all actively regulate fat metabolism without affecting eating behaviors in Caenorhabditis elegans , identified reduce mobilization via inhibiting these neurons. Optogenetic activation or inhibition the responsible neural circuit promotes loss gain storage, respectively. Furthermore, discovered FLP-1 neuropeptide released from this signals through peripheral NPR-4/neuropeptide receptor, SGK-1/serum- glucocorticoid-inducible kinase, isoforms DAF-16/FOXO transcription factor to storage. Our work reveals molecular mechanisms underlying regulation metabolism, suggests association between specificity each individual his/her susceptibility development obesity.

Language: Английский

Citations

73