Diet and depression: exploring the biological mechanisms of action

Molecular Psychiatry, Год журнала: 2020, Номер 26(1), С. 134 - 150

Опубликована: Ноя. 3, 2020

Язык: Английский

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A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders

Clinical Microbiology Reviews, Год журнала: 2022, Номер 35(1)

Опубликована: Янв. 5, 2022

The human body is full of an extensive number commensal microbes, consisting bacteria, viruses, and fungi, collectively termed the microbiome. initial acquisition microbiota occurs from both external maternal environments, vast majority them colonize gastrointestinal tract (GIT). These microbial communities play a central role in maturation development immune system, nervous GIT system are also responsible for essential metabolic pathways. Various factors, including host genetic predisposition, environmental lifestyle, diet, antibiotic or nonantibiotic drug use, etc., affect composition gut microbiota. Recent publications have highlighted that imbalance microflora, known as dysbiosis, associated with onset progression neurological disorders. Moreover, characterization microbiome-host cross talk pathways provides insight into novel therapeutic strategies. Novel preclinical clinical research on interventions related to microbiome treating conditions, autism spectrum disorders, Parkinson's disease, schizophrenia, multiple sclerosis, Alzheimer's epilepsy, stroke, hold significant promise. This review aims present comprehensive overview potential involvement pathogenesis particular emphasis microbe-based therapies and/or diagnostic biomarkers. discusses health benefits administration probiotics, prebiotics, postbiotics, synbiotics fecal transplantation

Язык: Английский

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Gut microbiota-mediated inflammation in obesity: a link with gastrointestinal cancer

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2018, Номер 15(11), С. 671 - 682

Опубликована: Май 29, 2018

Язык: Английский

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Gut Microbiome Dysbiosis and Immunometabolism: New Frontiers for Treatment of Metabolic Diseases

Mediators of Inflammation, Год журнала: 2018, Номер 2018, С. 1 - 12

Опубликована: Дек. 9, 2018

Maintenance of healthy human metabolism depends on a symbiotic consortium among bacteria, archaea, viruses, fungi, and host eukaryotic cells throughout the gastrointestinal tract. Microbial communities provide enzymatic machinery metabolic pathways that contribute to food digestion, xenobiotic metabolism, production variety bioactive molecules. These include vitamins, amino acids, short-chain fatty acids (SCFAs), metabolites, which are essential for interconnected glycolysis, tricarboxylic acid/Krebs cycle, oxidative phosphorylation (OXPHOS), acid metabolism. Recent studies have been elucidating how nutrients fuel processes impact ways immune cells, in particular, macrophages, respond different stimuli under physiological pathological conditions become activated acquire specialized function. The two major inflammatory phenotypes macrophages controlled through differential consumption glucose, glutamine, oxygen. M1 phenotype is triggered by polarization signal from bacterial lipopolysaccharide (LPS) Th1 proinflammatory cytokines such as interferon-γ, TNF-α, IL-1β, or both, whereas M2 Th2 interleukin-4 interleukin-13 well anti-inflammatory cytokines, IL-10 TGFβ, glucocorticoids. Glucose utilization chemical mediators including ATP, reactive oxygen species (ROS), nitric oxide (NO), NADPH support effector activities macrophages. Dysbiosis an imbalance commensal pathogenic bacteria microbial antigens metabolites. It now known gut microbiota-derived products induce low-grade activation tissue-resident degenerative diseases, diabetes, obesity, syndrome, cancer. Here, we update potential interplay microbiome dysbiosis diseases. We also summarize advances fecal therapy, probiotics, prebiotics, symbiotics, small molecule inhibitors pathway enzymes prophylactic therapeutic agents

Язык: Английский

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Gut Microbiota, Host Organism, and Diet Trialogue in Diabetes and Obesity

Frontiers in Nutrition, Год журнала: 2019, Номер 6

Опубликована: Март 13, 2019

The gastrointestinal tract with its microbiota is a complex, open and integrated ecosystem high environmental exposure. It widely accepted that the healthy gut essential for host homeostasis immunostasis, harboring an enormous number variety of microorganisms genes tailored by hundreds exogenous intrinsic factors. occurrence dysbiosis may contribute to vulnerability progression large spectrum infectious non-communicable diseases, including diabetes obesity, two metabolic disorders are showing endemic trend nowadays. There urgent need develop efficient strategies prevent treat such as obesity which areoften associated serious complications. In this paper, we give overview on implications in diabesity, focus triangle – diet - metabolism way manipulate microbial towards achieving novel diagnosis predictive biomarkers final goal re-establishing condition. current research data regarding precision/personalized nutrition suggest dietary interventions, administration pre-, pro-, synbiotics, well antibiotic treatment should be individually chronic diseases based genetic background, food beverage consumption, nutrient intake, microbiome, metabolome other omic profiles.

Язык: Английский

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The Microbiome and Aging

Annual Review of Genetics, Год журнала: 2019, Номер 53(1), С. 239 - 261

Опубликована: Сен. 5, 2019

Aging is a natural process of organismal decay that underpins the development myriad diseases and disorders. Extensive efforts have been made to understand biology aging its regulation, but most studies focus solely on host organism. Considering pivotal role microbiota in health metabolism, we propose viewing as single biological entity whose phenotype influenced by complex interplay between bacterial genetics. In this review present how changes ages, also intricate relationship indigenous bacteria impacts life span. addition, highlight other microbiota-dependent mechanisms potentially regulate aging, experimental animal models for addressing these questions. Importantly, microbiome dysbiosis an additional hallmark biomarker aging.

Язык: Английский

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Multi-omics data integration considerations and study design for biological systems and disease

Molecular Omics, Год журнала: 2020, Номер 17(2), С. 170 - 185

Опубликована: Дек. 21, 2020

Multi-omics data integration is used to investigate biological regulation of systems.

Язык: Английский

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Long noncoding RNA BFAL1 mediates enterotoxigenic Bacteroides fragilis-related carcinogenesis in colorectal cancer via the RHEB/mTOR pathway

Cell Death and Disease, Год журнала: 2019, Номер 10(9)

Опубликована: Сен. 12, 2019

Abstract Long noncoding RNAs (lncRNAs) contribute to many steps in carcinogenesis and often serve as biomarkers or therapeutic targets for tumor diagnosis therapy. Although the role of lncRNAs formation is becoming clear, whether mediate gut microbiota-induced colorectal cancer (CRC) largely unknown. Enterotoxigenic Bacteroides fragilis (ETBF) a well-known tumor-inducing bacterium human gut; however, its tumorigenic effect remains be explored. In present study, we revealed mechanism by which lncRNA participates bacteria-induced carcinogenesis: -associated lncRNA1 ( BFAL1 ) CRC tissues mediates ETBF carcinogenesis. was highly expressed compared with that adjacent normal tissues. vitro, upregulated ETBF-treated cells. Mechanistically, promoted growth via activating Ras homolog, MTORC1 binding/mammalian target rapamycin (RHEB/mTOR) pathway. Furthermore, regulated RHEB expression competitively sponging microRNAs miR-155-5p miR-200a-3p. Clinically, both high abundance predicted poor outcomes patients CRC. Thus, mediator ETBF-induced may potential

Язык: Английский

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Organoids and organs-on-chips: Insights into human gut-microbe interactions

Cell Host & Microbe, Год журнала: 2021, Номер 29(6), С. 867 - 878

Опубликована: Июнь 1, 2021

Язык: Английский

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Unraveling host regulation of gut microbiota through the epigenome–microbiome axis

Trends in Microbiology, Год журнала: 2024, Номер 32(12), С. 1229 - 1240

Опубликована: Июнь 5, 2024

Recent studies of dynamic interactions between epigenetic modifications a host organism and the composition or activity its associated gut microbiota suggest an opportunity for to shape microbiome through alterations that lead changes in gene expression noncoding RNA activity. We use insights from microbiota-induced review potential epigenetically regulate microbiome, which bidirectional 'epigenome–microbiome axis' emerges. This axis embeds environmentally induced variation, may influence adaptive evolution host–microbe interactions. furthermore present our perspective on how epigenome–microbiome can be understood investigated within holo-omic framework with applications applied health food sciences.

Язык: Английский

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