Science,
Год журнала:
2021,
Номер
374(6571), С. 1087 - 1092
Опубликована: Ноя. 25, 2021
The
brain
and
gastrointestinal
tract
are
critical
sensory
organs
responsible
for
detecting,
relaying,
integrating,
responding
to
signals
derived
from
the
internal
external
environment.
At
interface
of
this
function,
immune
cells
in
intestines
consistently
survey
environmental
factors,
eliciting
responses
that
inform
on
physiological
state
body.
Recent
research
reveals
cross-talk
along
gut-brain
axis
regulates
inflammatory
nociception,
responses,
homeostasis.
Here,
we
discuss
molecular
cellular
mechanisms
involved
signaling
inflammation
across
axis.
We
further
highlight
interactions
between
gut
inflammation-associated
diseases.
Frontiers in Immunology,
Год журнала:
2020,
Номер
11
Опубликована: Дек. 10, 2020
The
human
microbiota
has
a
fundamental
role
in
host
physiology
and
pathology.
Gut
microbial
alteration,
also
known
as
dysbiosis,
is
condition
associated
not
only
with
gastrointestinal
disorders
but
diseases
affecting
other
distal
organs.
Recently
it
became
evident
that
the
intestinal
bacteria
can
affect
central
nervous
system
(CNS)
inflammation.
tract
are
communicating
through
bidirectional
network
of
signaling
pathways
called
gut-brain
axis,
which
consists
multiple
connections,
including
vagus
nerve,
immune
system,
bacterial
metabolites
products.
During
these
dysregulated
altered
permeability
blood-brain
barrier
(BBB)
neuroinflammation.
However,
numerous
mechanisms
behind
impact
gut
neuro-development
-pathogenesis
remain
poorly
understood.
There
several
involved
CNS
homeostasis
Among
those,
inflammasome
pathway
been
linked
to
neuroinflammatory
conditions
such
sclerosis,
Alzheimer’s
Parkinson’s
diseases,
anxiety
depressive-like
disorders.
complex
assembles
upon
cell
activation
due
exposure
microbes,
danger
signals,
or
stress
lead
production
pro-inflammatory
cytokines
(interleukin-1β
interleukin-18)
pyroptosis.
Evidences
suggest
there
reciprocal
influence
brain.
how
this
precisely
working
yet
be
discovered.
Herein,
we
discuss
status
knowledge
open
questions
field
focusing
on
function
products
cells
during
healthy
inflammatory
conditions,
neuropsychiatric
In
particular,
focus
innate
mechanism
certain
microbes.
Science,
Год журнала:
2021,
Номер
374(6571), С. 1087 - 1092
Опубликована: Ноя. 25, 2021
The
brain
and
gastrointestinal
tract
are
critical
sensory
organs
responsible
for
detecting,
relaying,
integrating,
responding
to
signals
derived
from
the
internal
external
environment.
At
interface
of
this
function,
immune
cells
in
intestines
consistently
survey
environmental
factors,
eliciting
responses
that
inform
on
physiological
state
body.
Recent
research
reveals
cross-talk
along
gut-brain
axis
regulates
inflammatory
nociception,
responses,
homeostasis.
Here,
we
discuss
molecular
cellular
mechanisms
involved
signaling
inflammation
across
axis.
We
further
highlight
interactions
between
gut
inflammation-associated
diseases.
