The gut microbiome and liver cancer: mechanisms and clinical translation DOI

Le–Xing Yu,

Robert F. Schwabe

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2017, Volume and Issue: 14(9), P. 527 - 539

Published: July 5, 2017

Language: Английский

Tryptophan Metabolism: A Link Between the Gut Microbiota and Brain DOI Creative Commons
Kan Gao, Chunlong Mu, Aitak Farzi

et al.

Advances in Nutrition, Journal Year: 2019, Volume and Issue: 11(3), P. 709 - 723

Published: Nov. 8, 2019

Language: Английский

Citations

577
The Gut-Brain Axis: How Microbiota and Host Inflammasome Influence Brain Physiology and Pathology DOI Creative Commons

Andrina Rutsch,

Johan B. Kantsjö,

Francesca Ronchi

et al.

Frontiers in Immunology, Journal Year: 2020, Volume and Issue: 11

Published: Dec. 10, 2020

The human microbiota has a fundamental role in host physiology and pathology. Gut microbial alteration, also known as dysbiosis, is condition associated not only with gastrointestinal disorders but diseases affecting other distal organs. Recently it became evident that the intestinal bacteria can affect central nervous system (CNS) inflammation. tract are communicating through bidirectional network of signaling pathways called gut-brain axis, which consists multiple connections, including vagus nerve, immune system, bacterial metabolites products. During these dysregulated altered permeability blood-brain barrier (BBB) neuroinflammation. However, numerous mechanisms behind impact gut neuro-development -pathogenesis remain poorly understood. There several involved CNS homeostasis Among those, inflammasome pathway been linked to neuroinflammatory conditions such sclerosis, Alzheimer’s Parkinson’s diseases, anxiety depressive-like disorders. complex assembles upon cell activation due exposure microbes, danger signals, or stress lead production pro-inflammatory cytokines (interleukin-1β interleukin-18) pyroptosis. Evidences suggest there reciprocal influence brain. how this precisely working yet be discovered. Herein, we discuss status knowledge open questions field focusing on function products cells during healthy inflammatory conditions, neuropsychiatric In particular, focus innate mechanism certain microbes.

Language: Английский

Citations

571
Kynurenine pathway metabolism and the microbiota-gut-brain axis DOI
Paul J. Kennedy, John F. Cryan,

T.G. Dinan

et al.

Neuropharmacology, Journal Year: 2016, Volume and Issue: 112, P. 399 - 412

Published: July 6, 2016

Language: Английский

Citations

562
The multiple pathways to autoimmunity DOI

Argyrios N. Theofilopoulos,

Dwight H. Kono,

Roberto Baccalà

et al.

Nature Immunology, Journal Year: 2017, Volume and Issue: 18(7), P. 716 - 724

Published: June 20, 2017

Language: Английский

Citations

503
The gut microbiome and liver cancer: mechanisms and clinical translation DOI

Le–Xing Yu,

Robert F. Schwabe

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2017, Volume and Issue: 14(9), P. 527 - 539

Published: July 5, 2017

Language: Английский

Citations

491