The gut metabolite indole-3-propionic acid activates ERK1 to restore social function and hippocampal inhibitory synaptic transmission in a 16p11.2 microdeletion mouse model DOI Creative Commons
Jian Jiang,

Dilong Wang,

Youheng Jiang

и другие.

Microbiome, Год журнала: 2024, Номер 12(1)

Опубликована: Март 28, 2024

Abstract Background Microdeletion of the human chromosomal region 16p11.2 (16p11.2 $${}^{+/-}$$ + / - ) is a prevalent genetic factor associated with autism spectrum disorder (ASD) and other neurodevelopmental disorders. However its pathogenic mechanism remains unclear, effective treatments for syndrome are lacking. Emerging evidence suggests that gut microbiota metabolites inextricably linked to host behavior through gut-brain axis therefore implicated in ASD development. Despite this, functional roles microbial context yet be elucidated. This study aims investigate therapeutic potential indole-3-propionic acid (IPA), metabolite, addressing behavioral neural deficits , as well underlying molecular mechanisms. Results Mice showed dysbiosis significant decrease IPA levels feces blood circulation. Further, these mice exhibited social cognitive memory impairments, along hyperactivation hippocampal dentate gyrus neurons reduced inhibitory synaptic transmission this region. However, oral administration effectively mitigated histological electrophysiological alterations, thereby ameliorating mice. Remarkably, treatment significantly increased phosphorylation level ERK1, protein encoded by Mapk3 gene region, without affecting transcription translation gene. Conclusions Our reveals leads decline metabolite levels; however, supplementation notably reverses phenotypes These findings provide new insights into critical role pathogenesis present promising strategy deficit disorders, such microdeletion syndrome.

Язык: Английский

Whole-brain spatial organization of hippocampal single-neuron projectomes DOI
Shou Qiu, Yachuang Hu, Yiming Huang

и другие.

Science, Год журнала: 2024, Номер 383(6682)

Опубликована: Фев. 1, 2024

Mapping single-neuron projections is essential for understanding brain-wide connectivity and diverse functions of the hippocampus (HIP). Here, we reconstructed 10,100 projectomes mouse HIP classified 43 projectome subtypes with distinct projection patterns. The number targets axon-tip distribution depended on soma location along longitudinal transverse axes. Many were enriched in specific subdomains defined by spatial transcriptomic profiles. Furthermore, delineated comprehensive wiring diagrams neurons projecting exclusively within formation (HPF) those to both intra- extra-HPF targets. Bihemispheric generally projected one pair homologous ipsilateral preference. These organization principles provide a structural basis function neurons.

Язык: Английский

Процитировано

36
Posterior basolateral amygdala to ventral hippocampal CA1 drives approach behaviour to exert an anxiolytic effect DOI Creative Commons
Guilin Pi, Di Gao, Dongqin Wu

и другие.

Nature Communications, Год журнала: 2020, Номер 11(1)

Опубликована: Янв. 10, 2020

Abstract The basolateral amygdala (BLA) and ventral hippocampal CA1 (vCA1) are cellularly functionally diverse along their anterior–posterior superficial-deep axes. Here, we find that anterior BLA (aBLA) posterior (pBLA) innervate deep-layer calbindin1-negative (Calb1−) superficial-layer calbindin1-positive neurons (Calb1+) in vCA1, respectively. Photostimulation of pBLA–vCA1 inputs has an anxiolytic effect mice, promoting approach behaviours during conflict exploratory tasks. By contrast, stimulating aBLA–vCA1 induces anxiety-like behaviour resulting fewer approaches. During stages the elevated plus maze task vCA1 Calb1+ preferentially activated at open-to-closed arm transition, photostimulation decision-making zones promotes with retreats. In APP/PS1 mouse model Alzheimer’s disease, which shows behaviour, photostimulating circuit ameliorates anxiety a Calb1-dependent manner. These findings suggest from heterogeneous BLA–vCA1 connections drives to reduce behaviour.

Язык: Английский

Процитировано

128
Differential Emergence and Stability of Sensory and Temporal Representations in Context-Specific Hippocampal Sequences DOI Creative Commons
Jiannis Taxidis, Eftychios A. Pnevmatikakis, Conor C. Dorian

и другие.

Neuron, Год журнала: 2020, Номер 108(5), С. 984 - 998.e9

Опубликована: Сен. 18, 2020

Язык: Английский

Процитировано

123
An olfactory virtual reality system for mice DOI Creative Commons

Brad A. Radvansky,

Daniel A. Dombeck

Nature Communications, Год журнала: 2018, Номер 9(1)

Опубликована: Фев. 20, 2018

Abstract All motile organisms use spatially distributed chemical features of their surroundings to guide behaviors, but the neural mechanisms underlying such behaviors in mammals have been difficult study, largely due technical challenges controlling concentrations space and time during behavioral experiments. To overcome these challenges, we introduce a system control maintain an olfactory virtual landscape. This uses rapid flow controllers online predictive algorithm deliver precise odorant distributions head-fixed mice as they explore environment. We establish odor-guided navigation behavior that engages hippocampal CA1 “place cells” exhibit similar properties those previously reported for real visual environments, demonstrating based on different sensory modalities recruits cognitive map. method opens new possibilities studying olfactory-driven multisensory integration, innate valence, low-dimensional sensory-spatial processing.

Язык: Английский

Процитировано

104
Dopamine facilitates associative memory encoding in the entorhinal cortex DOI
Jason Y. Lee, Heechul Jun, Shogo Soma

и другие.

Nature, Год журнала: 2021, Номер 598(7880), С. 321 - 326

Опубликована: Сен. 22, 2021

Язык: Английский

Процитировано

98
A SERS Optophysiological Probe for the Real‐Time Mapping and Simultaneous Determination of the Carbonate Concentration and pH Value in a Live Mouse Brain DOI

Weikang Wang,

Fan Zhao, Mingzhi Li

и другие.

Angewandte Chemie International Edition, Год журнала: 2019, Номер 58(16), С. 5256 - 5260

Опубликована: Фев. 27, 2019

Abstract To have a profound understanding of the physiological and pathological processes in brain, both chemical electrical signals need to be recorded, but this is still very challenging. Herein, micrometer‐ nanometer‐sized SERS optophysiological probes were created determine CO 3 2− concentration pH live brains neurons because species play important roles regulating acid–base balance brain. A ratiometric microarray eight microprobes with tip sizes 5 μm was established used for first time real‐time mapping simultaneous quantification We found that value dramatically decreased under ischemic conditions. The present technique can combined electrophysiology without cross‐talk record brains. deepen our mechanism ischemia on single‐cell level, nanoprobe size 200 nm developed use single neuron.

Язык: Английский

Процитировано

93
Viral Vectors for Neural Circuit Mapping and Recent Advances in Trans-synaptic Anterograde Tracers DOI Creative Commons
Xiangmin Xu, Todd C. Holmes, Min‐Hua Luo

и другие.

Neuron, Год журнала: 2020, Номер 107(6), С. 1029 - 1047

Опубликована: Авг. 4, 2020

Язык: Английский

Процитировано

93
A Role of Drd2 Hippocampal Neurons in Context-Dependent Food Intake DOI Creative Commons
Estefania P. Azevedo, Lisa E. Pomeranz, Jia Cheng

и другие.

Neuron, Год журнала: 2019, Номер 102(4), С. 873 - 886.e5

Опубликована: Март 28, 2019

Язык: Английский

Процитировано

82
How development sculpts hippocampal circuits and function DOI
Rosa Cossart, Roustem Khazipov

Physiological Reviews, Год журнала: 2021, Номер 102(1), С. 343 - 378

Опубликована: Июль 19, 2021

In mammals, the selective transformation of transient experience into stored memory occurs in hippocampus, which develops representations specific events context they occur. this review, we focus on development hippocampal circuits and self-organized dynamics embedded within them since latter critically support role hippocampus learning memory. We first discuss evidence that adult cells are sculpted by as early during embryonic neurogenesis. argue these primary developmental programs provide a scaffold onto later external world can be grafted. Next, review different sequences at anatomical functional levels. cover period extending from neurogenesis migration to appearance phenotypic diversity their wiring networks. describe progressive emergence network sensorimotor-driven sharp waves place tracking relational information. outline critical turn points discontinuities journey, close formulating open questions. propose rewinding process helps understand main organization principles circuits.

Язык: Английский

Процитировано

82
The Dentate Gyrus Classifies Cortical Representations of Learned Stimuli DOI Creative Commons
Nicholas I. Woods, Fabio Stefanini,

Daniel L. Apodaca-Montano

и другие.

Neuron, Год журнала: 2020, Номер 107(1), С. 173 - 184.e6

Опубликована: Апрель 30, 2020

Язык: Английский

Процитировано

75