Dynamic heterogeneity and non-Gaussian statistics for acetylcholine receptors on live cell membrane DOI Creative Commons
Wei He, Hao Song, Yun Su

и другие.

Nature Communications, Год журнала: 2016, Номер 7(1)

Опубликована: Май 26, 2016

The Brownian motion of molecules at thermal equilibrium usually has a finite correlation time and will eventually be randomized after long delay time, so that their displacement follows the Gaussian statistics. This is true even when have experienced complex environment with time. Here, we report lateral acetylcholine receptors on live muscle cell membranes does not follow statistics for normal diffusion. From careful analysis large volume protein trajectories obtained over wide range sampling rates durations, find normalized histogram displacements shows an exponential tail, which robust universal cells under different conditions. experiment indicates observed non-Gaussian dynamic heterogeneity are inherently linked to slow-active remodelling underlying cortical actin network.

Язык: Английский

The stiffness of living tissues and its implications for tissue engineering DOI
Carlos F. Guimarães, Luca Gasperini, Alexandra P. Marques

и другие.

Nature Reviews Materials, Год журнала: 2020, Номер 5(5), С. 351 - 370

Опубликована: Фев. 21, 2020

Язык: Английский

Процитировано

1155

Topological mechanics of gyroscopic metamaterials DOI Open Access

Lisa M. Nash,

Dustin Kleckner,

Alismari Read

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2015, Номер 112(47), С. 14495 - 14500

Опубликована: Ноя. 11, 2015

Topological mechanical metamaterials are artificial structures whose unusual properties protected very much like their electronic and optical counterparts. Here, we present an experimental theoretical study of active metamaterial -- comprised coupled gyroscopes on a lattice that breaks time-reversal symmetry. The vibrational spectrum these novel displays sonic gap populated by topologically edge modes which propagate in only one direction unaffected disorder. We mathematical model explains how the mode chirality can be switched via controlled distortions underlying lattice. This effect allows current to determined demand. envision applications edges design loss-free, one-way, acoustic waveguides demonstrate this functionality experiment.

Язык: Английский

Процитировано

748

Topological defects in epithelia govern cell death and extrusion DOI
Thuan Beng Saw, Amin Doostmohammadi, Vincent Nier

и другие.

Nature, Год журнала: 2017, Номер 544(7649), С. 212 - 216

Опубликована: Апрель 11, 2017

Язык: Английский

Процитировано

684

Active matter at the interface between materials science and cell biology DOI
Daniel Needleman, Zvonimir Dogic

Nature Reviews Materials, Год журнала: 2017, Номер 2(9)

Опубликована: Июль 18, 2017

Язык: Английский

Процитировано

559

Active nematics DOI Creative Commons
Amin Doostmohammadi, Jordi Ignés‐Mullol, Julia M. Yeomans

и другие.

Nature Communications, Год журнала: 2018, Номер 9(1)

Опубликована: Авг. 8, 2018

Active matter extracts energy from its surroundings at the single particle level and transforms it into mechanical work. Examples include cytoskeleton biopolymers bacterial suspensions. Here, we review experimental, theoretical numerical studies of active nematics - a type system that is characterised by self-driven units with elongated shape. We focus primarily on microtubule-kinesin mixtures hydrodynamic theories describe their properties. An important theme turbulence associated motile topological defects. discuss ways in which may be controlled, pre-requisite to harvesting materials, consider appearance, possible implications, defects cellular systems biological processes.

Язык: Английский

Процитировано

558

The 2020 motile active matter roadmap DOI Creative Commons
Gerhard Gompper, Roland G. Winkler, Thomas Speck

и другие.

Journal of Physics Condensed Matter, Год журнала: 2020, Номер 32(19), С. 193001 - 193001

Опубликована: Фев. 14, 2020

Abstract Activity and autonomous motion are fundamental in living engineering systems. This has stimulated the new field of ‘active matter’ recent years, which focuses on physical aspects propulsion mechanisms, motility-induced emergent collective behavior a larger number identical agents. The scale agents ranges from nanomotors microswimmers, to cells, fish, birds, people. Inspired by biological various designs synthetic nano- micromachines have been proposed. Such machines provide basis for multifunctional, highly responsive, intelligent (artificial) active materials, exhibit ability perform tasks response external stimuli. A major challenge understanding designing matter is their inherent nonequilibrium nature due persistent energy consumption, invalidates equilibrium concepts such as free energy, detailed balance, time-reversal symmetry. Unraveling, predicting, controlling truly interdisciplinary endeavor at interface biology, chemistry, ecology, engineering, mathematics, physics. vast complexity phenomena mechanisms involved self-organization dynamics motile comprises challenge. Hence, advance, eventually reach comprehensive understanding, this important research area requires concerted, synergetic approach disciplines. 2020 roadmap Journal Physics: Condensed Matter addresses current state art provides guidance both students well established scientists efforts advance fascinating area.

Язык: Английский

Процитировано

411

Physical principles of intracellular organization via active and passive phase transitions DOI
Joel Berry, Clifford P. Brangwynne, Mikko Haataja

и другие.

Reports on Progress in Physics, Год журнала: 2018, Номер 81(4), С. 046601 - 046601

Опубликована: Янв. 9, 2018

Exciting recent developments suggest that phase transitions represent an important and ubiquitous mechanism underlying intracellular organization. We describe key experimental findings in this area of study, as well the application classical theoretical approaches for quantitatively understanding these data. also discuss way which equilibrium thermodynamic driving forces may interface with fundamentally out-of-equilibrium nature living cells. In particular, time and/or space-dependent concentration profiles modulate behavior biomolecules future directions both work will shed light on biological activity modulates assembly, properties, function viscoelastic states matter.

Язык: Английский

Процитировано

410

Tensile Forces and Mechanotransduction at Cell–Cell Junctions DOI Creative Commons
Guillaume Charras, Alpha S. Yap

Current Biology, Год журнала: 2018, Номер 28(8), С. R445 - R457

Опубликована: Апрель 1, 2018

Язык: Английский

Процитировано

372

Focal Adhesion–Independent Cell Migration DOI Open Access
Ewa K. Paluch, Irene M. Aspalter, Michael Sixt

и другие.

Annual Review of Cell and Developmental Biology, Год журнала: 2016, Номер 32(1), С. 469 - 490

Опубликована: Авг. 8, 2016

Cell migration is central to a multitude of physiological processes, including embryonic development, immune surveillance, and wound healing, deregulated key cancer dissemination. Decades investigations have uncovered many the molecular physical mechanisms underlying cell migration. Together with protrusion extension body retraction, adhesion substrate via specific focal points has long been considered an essential step in Although this true for cells moving on two-dimensional substrates, recent studies demonstrated that adhesions are not required three dimensions, which confinement sufficient maintain contact its substrate. Here, we review led challenging requirement migration, discuss proposed translocation during adhesion-independent highlight remaining open questions future.

Язык: Английский

Процитировано

340

Computational models for active matter DOI
M. Reza Shaebani,

Adam Wysocki,

Roland G. Winkler

и другие.

Nature Reviews Physics, Год журнала: 2020, Номер 2(4), С. 181 - 199

Опубликована: Март 10, 2020

Язык: Английский

Процитировано

314