Dynamic heterogeneity and non-Gaussian statistics for acetylcholine receptors on live cell membrane DOI Creative Commons
Wei He, Hao Song, Yun Su

et al.

Nature Communications, Journal Year: 2016, Volume and Issue: 7(1)

Published: May 26, 2016

The Brownian motion of molecules at thermal equilibrium usually has a finite correlation time and will eventually be randomized after long delay time, so that their displacement follows the Gaussian statistics. This is true even when have experienced complex environment with time. Here, we report lateral acetylcholine receptors on live muscle cell membranes does not follow statistics for normal diffusion. From careful analysis large volume protein trajectories obtained over wide range sampling rates durations, find normalized histogram displacements shows an exponential tail, which robust universal cells under different conditions. experiment indicates observed non-Gaussian dynamic heterogeneity are inherently linked to slow-active remodelling underlying cortical actin network.

Language: Английский

The stiffness of living tissues and its implications for tissue engineering DOI
Carlos F. Guimarães, Luca Gasperini, Alexandra P. Marques

et al.

Nature Reviews Materials, Journal Year: 2020, Volume and Issue: 5(5), P. 351 - 370

Published: Feb. 21, 2020

Language: Английский

Citations

1153

Topological mechanics of gyroscopic metamaterials DOI Open Access

Lisa M. Nash,

Dustin Kleckner,

Alismari Read

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2015, Volume and Issue: 112(47), P. 14495 - 14500

Published: Nov. 11, 2015

Topological mechanical metamaterials are artificial structures whose unusual properties protected very much like their electronic and optical counterparts. Here, we present an experimental theoretical study of active metamaterial -- comprised coupled gyroscopes on a lattice that breaks time-reversal symmetry. The vibrational spectrum these novel displays sonic gap populated by topologically edge modes which propagate in only one direction unaffected disorder. We mathematical model explains how the mode chirality can be switched via controlled distortions underlying lattice. This effect allows current to determined demand. envision applications edges design loss-free, one-way, acoustic waveguides demonstrate this functionality experiment.

Language: Английский

Citations

744

Topological defects in epithelia govern cell death and extrusion DOI
Thuan Beng Saw, Amin Doostmohammadi, Vincent Nier

et al.

Nature, Journal Year: 2017, Volume and Issue: 544(7649), P. 212 - 216

Published: April 11, 2017

Language: Английский

Citations

680

Active matter at the interface between materials science and cell biology DOI
Daniel Needleman, Zvonimir Dogic

Nature Reviews Materials, Journal Year: 2017, Volume and Issue: 2(9)

Published: July 18, 2017

Language: Английский

Citations

559

Active nematics DOI Creative Commons
Amin Doostmohammadi, Jordi Ignés‐Mullol, Julia M. Yeomans

et al.

Nature Communications, Journal Year: 2018, Volume and Issue: 9(1)

Published: Aug. 8, 2018

Active matter extracts energy from its surroundings at the single particle level and transforms it into mechanical work. Examples include cytoskeleton biopolymers bacterial suspensions. Here, we review experimental, theoretical numerical studies of active nematics - a type system that is characterised by self-driven units with elongated shape. We focus primarily on microtubule-kinesin mixtures hydrodynamic theories describe their properties. An important theme turbulence associated motile topological defects. discuss ways in which may be controlled, pre-requisite to harvesting materials, consider appearance, possible implications, defects cellular systems biological processes.

Language: Английский

Citations

557

Physical principles of intracellular organization via active and passive phase transitions DOI
Joel Berry, Clifford P. Brangwynne, Mikko Haataja

et al.

Reports on Progress in Physics, Journal Year: 2018, Volume and Issue: 81(4), P. 046601 - 046601

Published: Jan. 9, 2018

Exciting recent developments suggest that phase transitions represent an important and ubiquitous mechanism underlying intracellular organization. We describe key experimental findings in this area of study, as well the application classical theoretical approaches for quantitatively understanding these data. also discuss way which equilibrium thermodynamic driving forces may interface with fundamentally out-of-equilibrium nature living cells. In particular, time and/or space-dependent concentration profiles modulate behavior biomolecules future directions both work will shed light on biological activity modulates assembly, properties, function viscoelastic states matter.

Language: Английский

Citations

406

The 2020 motile active matter roadmap DOI Creative Commons
Gerhard Gompper, Roland G. Winkler, Thomas Speck

et al.

Journal of Physics Condensed Matter, Journal Year: 2020, Volume and Issue: 32(19), P. 193001 - 193001

Published: Feb. 14, 2020

Abstract Activity and autonomous motion are fundamental in living engineering systems. This has stimulated the new field of ‘active matter’ recent years, which focuses on physical aspects propulsion mechanisms, motility-induced emergent collective behavior a larger number identical agents. The scale agents ranges from nanomotors microswimmers, to cells, fish, birds, people. Inspired by biological various designs synthetic nano- micromachines have been proposed. Such machines provide basis for multifunctional, highly responsive, intelligent (artificial) active materials, exhibit ability perform tasks response external stimuli. A major challenge understanding designing matter is their inherent nonequilibrium nature due persistent energy consumption, invalidates equilibrium concepts such as free energy, detailed balance, time-reversal symmetry. Unraveling, predicting, controlling truly interdisciplinary endeavor at interface biology, chemistry, ecology, engineering, mathematics, physics. vast complexity phenomena mechanisms involved self-organization dynamics motile comprises challenge. Hence, advance, eventually reach comprehensive understanding, this important research area requires concerted, synergetic approach disciplines. 2020 roadmap Journal Physics: Condensed Matter addresses current state art provides guidance both students well established scientists efforts advance fascinating area.

Language: Английский

Citations

406

Tensile Forces and Mechanotransduction at Cell–Cell Junctions DOI Creative Commons
Guillaume Charras, Alpha S. Yap

Current Biology, Journal Year: 2018, Volume and Issue: 28(8), P. R445 - R457

Published: April 1, 2018

Language: Английский

Citations

369

Focal Adhesion–Independent Cell Migration DOI Open Access
Ewa K. Paluch, Irene M. Aspalter, Michael Sixt

et al.

Annual Review of Cell and Developmental Biology, Journal Year: 2016, Volume and Issue: 32(1), P. 469 - 490

Published: Aug. 8, 2016

Cell migration is central to a multitude of physiological processes, including embryonic development, immune surveillance, and wound healing, deregulated key cancer dissemination. Decades investigations have uncovered many the molecular physical mechanisms underlying cell migration. Together with protrusion extension body retraction, adhesion substrate via specific focal points has long been considered an essential step in Although this true for cells moving on two-dimensional substrates, recent studies demonstrated that adhesions are not required three dimensions, which confinement sufficient maintain contact its substrate. Here, we review led challenging requirement migration, discuss proposed translocation during adhesion-independent highlight remaining open questions future.

Language: Английский

Citations

340

Computational models for active matter DOI
M. Reza Shaebani,

Adam Wysocki,

Roland G. Winkler

et al.

Nature Reviews Physics, Journal Year: 2020, Volume and Issue: 2(4), P. 181 - 199

Published: March 10, 2020

Language: Английский

Citations

311