Advanced Functional Materials,
Год журнала:
2021,
Номер
32(17)
Опубликована: Дек. 26, 2021
Chronic
wounds
are
a
major
healthcare
issue
and
can
adversely
affect
the
lives
of
millions
patients
around
world.
The
current
wound
management
strategies
have
limited
clinical
efficacy
due
to
labor-intensive
lab
analysis
requirements,
need
for
clinicians'
experiences,
long-term
frequent
interventions,
limiting
therapeutic
efficiency
applicability.
growing
field
flexible
bioelectronics
enables
great
potential
personalized
care
owing
its
advantages
such
as
wearability,
low-cost,
rapid
simple
application.
Herein,
recent
advances
in
development
wearable
monitoring
chronic
comprehensively
reviewed.
First,
design
principles
key
features
that
adapt
unique
milieu
introduced.
Next,
state
biosensors
on-demand
systems
summarized
highlighted.
Furthermore,
we
discuss
criteria
integrated
closed
loop
devices.
Finally,
future
perspectives
challenges
discussed.
Chemical Reviews,
Год журнала:
2021,
Номер
121(18), С. 11336 - 11384
Опубликована: Янв. 28, 2021
Polymeric
tissue
adhesives
provide
versatile
materials
for
wound
management
and
are
widely
used
in
a
variety
of
medical
settings
ranging
from
minor
to
life-threatening
injuries.
Compared
the
traditional
methods
closure
(i.e.,
suturing
stapling),
they
relatively
easy
use,
enable
rapid
application,
introduce
minimal
damage.
Furthermore,
can
act
as
hemostats
control
bleeding
tissue-healing
environment
at
site.
Despite
their
numerous
current
applications,
still
face
several
limitations
unresolved
challenges
(e.g.,
weak
adhesion
strength
poor
mechanical
properties)
that
limit
leaving
ample
room
future
improvements.
Successful
development
next-generation
will
likely
require
holistic
understanding
chemical
physical
properties
tissue-adhesive
interface,
fundamental
mechanisms
adhesion,
requirements
specific
clinical
applications.
In
this
review,
we
discuss
set
rational
guidelines
design
adhesives,
recent
progress
field
along
with
examples
commercially
available
those
under
development,
tissue-specific
considerations,
finally
potential
functions
adhesives.
Advances
open
new
avenues
care
potentially
potent
therapeutics
various
Advances
in
medical
robots
promise
to
improve
modern
medicine
and
the
quality
of
life.
Miniaturization
these
robotic
platforms
has
led
numerous
applications
that
leverages
precision
medicine.
In
this
review,
current
trends
micro
nanorobotics
for
therapy,
surgery,
diagnosis,
imaging
are
discussed.
The
use
nanorobots
still
faces
technical,
regulatory,
market
challenges
their
widespread
clinical
settings.
Nevertheless,
recent
translations
from
proof
concept
vivo
studies
demonstrate
potential
toward
Bioactive Materials,
Год журнала:
2020,
Номер
6(4), С. 1083 - 1106
Опубликована: Окт. 15, 2020
Polyurethanes
(PUs)
are
a
major
family
of
polymers
displaying
wide
spectrum
physico-chemical,
mechanical
and
structural
properties
for
large
range
fields.
They
have
shown
suitable
biomedical
applications
used
in
this
domain
since
decades.
The
current
variety
biomass
available
has
extended
the
diversity
starting
materials
elaboration
new
biobased
macromolecular
architectures,
allowing
development
PUs
with
advanced
such
as
controlled
biotic
abiotic
degradation.
In
frame,
tunable
devices
been
successfully
designed.
PU
structures
precise
tissue
biomimicking
can
be
obtained
adequate
adhesion,
proliferation
differentiation
many
cell's
types.
Moreover,
smart
shape-memory
adjustable
shape-recovery
demonstrated
promising
results
wound
healing.
fossil-based
substitution
implants
is
slowly
improving,
nonetheless
better
renewable
contents
need
to
achieved
most
obtain
certifications.
After
presentation
some
generalities
an
understanding
biomaterial
structure-biocompatibility
relationship,
recent
developments
non-implantable
well
short-
long-term
described
detail
review
compared
more
conventional
structures.
Chemical Reviews,
Год журнала:
2021,
Номер
122(5), С. 5365 - 5403
Опубликована: Фев. 1, 2021
Over
the
past
15
years,
field
of
microrobotics
has
exploded
with
many
research
groups
from
around
globe
contributing
to
numerous
innovations
that
have
led
exciting
new
capabilities
and
important
applications,
ranging
in
vivo
drug
delivery,
intracellular
biosensing,
environmental
remediation,
nanoscale
fabrication.
Smart
responsive
materials
had
a
profound
impact
on
imparted
small-scale
robots
functionalities
distinct
capabilities.
We
identified
four
large
categories
where
majority
future
efforts
must
be
allocated
push
frontiers
microrobots
smart
can
major
such
advances.
These
areas
are
propulsion
biocompatibility
microrobots,
cooperation
between
individual
units
human
operators,
finally,
intelligence
microrobots.
In
this
Review,
we
look
critically
at
latest
developments
these
discuss
how
contribute
progress
will
set
stage
for
next
generation
intelligent
programmable
Advanced Materials,
Год журнала:
2021,
Номер
33(12)
Опубликована: Фев. 9, 2021
Human
immune
system
acts
as
a
pivotal
role
in
the
tissue
homeostasis
and
disease
progression.
Immunomodulatory
biomaterials
that
can
manipulate
innate
immunity
adaptive
hold
great
promise
for
broad
range
of
prophylactic
therapeutic
purposes.
This
review
is
focused
on
design
strategies
principles
immunomodulatory
from
standpoint
materials
science
to
regulate
macrophage
fate,
such
activation,
polarization,
adhesion,
migration,
proliferation,
secretion.
It
offers
comprehensive
survey
discussion
tunability
material
designs
regarding
physical,
chemical,
biological,
dynamic
cues
modulating
response.
The
tailorable
encompasses
surface
properties,
topography,
mechanics,
composition,
dynamics.
representative
immunoengineering
applications
selected
herein
demonstrate
how
macrophage-immunomodulating
are
being
exploited
cancer
immunotherapy,
infection
regeneration,
inflammation
resolution,
vaccination.
A
perspective
future
research
directions
immunoregulatory
also
provided.
Nature Communications,
Год журнала:
2022,
Номер
13(1)
Опубликована: Янв. 18, 2022
Abstract
Soft
electronics
are
rising
electronic
technologies
towards
applications
spanning
from
healthcare
monitoring
to
medical
implants.
However,
poor
adhesion
strength
and
significant
mechanical
mismatches
inevitably
cause
the
interface
failure
of
devices.
Herein
we
report
a
self-adhesive
conductive
polymer
that
possesses
low
modulus
(56.1-401.9
kPa),
high
stretchability
(700%),
interfacial
(lap-shear
>1.2
MPa),
conductivity
(1-37
S/cm).
The
is
fabricated
by
doping
poly(3,4-ethylenedioxythiophene):
poly(styrene
sulfonate)
composite
with
supramolecular
solvent
(β-cyclodextrin
citric
acid).
We
demonstrated
solution
process-based
fabrication
polymer-based
electrodes
for
various
soft
devices,
including
alternating
current
electroluminescent
electromyography
monitoring,
an
integrated
system
visualization
signals
during
muscle
training
array
show
promising
features
further
develop
wearable
comfortable
bioelectronic
devices
physiological
electric
human
body
readable
displayable
daily
activities.
Advanced Functional Materials,
Год журнала:
2020,
Номер
30(42)
Опубликована: Авг. 18, 2020
Abstract
Hydrogels
are
one
of
the
most
commonly
explored
classes
biomaterials.
Their
chemical
and
structural
versatility
has
enabled
their
use
across
a
wide
range
applications,
including
tissue
engineering,
drug
delivery,
cell
culture.
form
upon
sol–gel
transition,
which
can
be
elicited
by
different
triggers
designed
to
enable
precise
control
over
hydrogelation
kinetics
hydrogel
structure.
The
chosen
trigger
chemistry
have
profound
effect
on
success
targeted
application.
In
this
Progress
Report,
critical
overview
recent
advances
in
design
is
presented,
with
focus
available
strategies
used
formation
networks
(e.g.,
temperature,
light,
ultrasound).
These
presented
within
new
classification
system,
suitability
for
six
key
hydrogel‐based
applications
assessed.
This
Report
intended
guide
selection
inspire
rational
mechanisms.
