Harvard Review of Psychiatry,
Год журнала:
2018,
Номер
26(3), С. 158 - 174
Опубликована: Май 1, 2018
Resilience
is
defined
as
the
dynamic
ability
to
adapt
successfully
in
face
of
adversity,
trauma,
or
significant
threat.
Some
key
early
studies
resilience
were
observational
children.
They
followed
by
research
adults,
testing
interventions
promote
different
populations,
and
a
recent
upsurge
on
underlying
genomic
neurobiological
mechanisms.
Neural
molecular
preclinical
models
are
also
increasingly
identifying
active
stress
adaptations
resilient
animals.
Knowledge
gained
from
animal
human
can
be
harnessed
develop
new
preventive
enhance
at-risk
populations.
Further,
treatment
focused
enhancing
potentially
modifiable
protective
factors
that
consistently
linked
psychological
enrich
currently
available
for
individuals
with
posttraumatic
disorder
(PTSD).
Translating
our
expanding
knowledge
neurobiology
additionally
promises
yield
novel
therapeutic
strategies
treating
this
disabling
condition.
This
review
summarizes
vast
field
spanning
genomic,
psychosocial,
levels,
discusses
how
findings
have
led
lead
PTSD.
JAMA Psychiatry,
Год журнала:
2016,
Номер
73(3), С. 292 - 292
Опубликована: Фев. 4, 2016
With
a
political
debate
about
the
potential
risks
and
benefits
of
cannabis
use
as
backdrop,
wave
legalization
liberalization
initiatives
continues
to
spread.
Four
states
(Colorado,
Washington,
Oregon,
Alaska)
District
Columbia
have
passed
laws
that
legalized
for
recreational
by
adults,
23
others
plus
now
regulate
medical
purposes.
These
policy
changes
could
trigger
broad
range
unintended
consequences,
with
profound
lasting
implications
health
social
systems
in
our
country.
Cannabis
is
emerging
one
among
many
interacting
factors
can
affect
brain
development
mental
function.
To
inform
discourse
scientific
evidence,
literature
was
reviewed
identify
what
known
not
effects
on
human
behavior,
including
cognition,
motivation,
psychosis.
The International Journal of Neuropsychopharmacology,
Год журнала:
2020,
Номер
23(6), С. 385 - 400
Опубликована: Март 12, 2020
There
are
few
medications
with
demonstrated
efficacy
for
the
treatment
of
posttraumatic
stress
disorder
(PTSD).
Treatment
guidelines
have
unequivocally
designated
psychotherapy
as
a
first
line
PTSD.
Yet,
even
after
psychotherapy,
PTSD
often
remains
chronic
illness,
high
rates
psychiatric
and
medical
comorbidity.
Meanwhile,
search
development
drugs
new
mechanisms
action
has
stalled.
Therefore,
there
is
an
urgent
need
to
explore
not
just
novel
compounds
but
approaches
A
promising
approach
involves
use
psychedelic
drugs.
Within
past
years,
2
psychedelics
received
breakthrough
designations
indications
from
US
Food
Drug
Administration,
several
currently
being
investigated
This
review
discusses
4
types
compounds:
3,4-methylenedioxymethamphetamine,
ketamine,
classical
(e.g.,
psilocybin
lysergic
acid
diethylamide),
cannabinoids.
We
describe
therapeutic
rationale,
setting
in
which
they
administered,
their
current
state
evidence
Each
compound
provides
unique
qualities
PTSD,
rapidly
target
symptoms
adjuncts
facilitate
psychotherapeutic
treatments.
Several
questions
formulated
that
outline
agenda
future
research.
Progress in Lipid Research,
Год журнала:
2018,
Номер
71, С. 1 - 17
Опубликована: Май 8, 2018
2-Arachidonoylglycerol
(2-AG)
is
a
signaling
lipid
in
the
central
nervous
system
that
key
regulator
of
neurotransmitter
release.
2-AG
an
endocannabinoid
activates
cannabinoid
CB1
receptor.
It
involved
wide
array
(patho)physiological
functions,
such
as
emotion,
cognition,
energy
balance,
pain
sensation
and
neuroinflammation.
In
this
review,
we
describe
biosynthetic
metabolic
pathways
how
chemical
genetic
perturbation
these
has
led
to
insight
biological
role
lipid.
Finally,
discuss
potential
therapeutic
benefits
modulating
levels
brain.
Biological Psychiatry,
Год журнала:
2019,
Номер
87(6), С. 538 - 547
Опубликована: Авг. 13, 2019
BackgroundPosttraumatic
stress
disorder,
an
area
of
large
unmet
medical
needs,
is
characterized
by
persistence
fear
memories
and
maladaptive
responses.
In
rodents,
elevation
the
endocannabinoid
anandamide
due
to
inhibition
fatty
acid
amide
hydrolase
(FAAH)
facilitates
extinction
protects
against
anxiogenic
effects
stress.
We
recently
reported
that
elevated
levels
in
people
homozygous
for
a
loss-of-function
FAAH
mutation
are
associated
with
similar
phenotype,
suggesting
translational
validity
preclinical
findings.MethodsIn
this
double-blind,
placebo-controlled
experimental
medicine
study,
healthy
adults
were
randomized
inhibitor
(PF-04457845,
4
mg
orally,
once
daily;
n
=
16)
or
placebo
(n
29)
10
days.
On
days
9
10,
participants
completed
task
battery
assessing
psychophysiological
indices
learning,
reactivity,
stress-induced
affective
responses.ResultsFAAH
produced
10-fold
increase
baseline
anandamide.
This
was
potentiated
recall
memory
when
tested
24
hours
after
training.
also
attenuated
autonomic
assessed
via
electrodermal
activity,
protected
negative
affect,
measured
facial
electromyography.ConclusionsOur
data
provide
preliminary
human
evidence
can
improve
attenuate
stress,
direct
translation
rodent
findings.
The
beneficial
on
extinction,
as
well
stress-
affect-related
behaviors,
strong
rationale
developing
drug
class
treatment
posttraumatic
disorder.
