Endocannabinoid signalling modulates susceptibility to traumatic stress exposure DOI Creative Commons
Rebecca J. Bluett,

Rita Báldi,

Andre Haymer

et al.

Nature Communications, Journal Year: 2017, Volume and Issue: 8(1)

Published: March 28, 2017

Abstract Stress is a ubiquitous risk factor for the exacerbation and development of affective disorders including major depression posttraumatic stress disorder. Understanding neurobiological mechanisms conferring resilience to adverse consequences could have broad implications treatment prevention mood anxiety disorders. We utilize laboratory mice their innate inter-individual differences in stress-susceptibility demonstrate critical role endogenous cannabinoid 2-arachidonoylglycerol (2-AG) stress-resilience. Specifically, systemic 2-AG augmentation associated with stress-resilient phenotype enhances previously susceptible mice, while depletion or CB1 receptor blockade increases susceptibility resilient mice. Moreover, stress-resilience increased phasic 2-AG-mediated synaptic suppression at ventral hippocampal-amygdala glutamatergic synapses amygdala-specific impairs successful adaptation repeated stress. These data indicate amygdala signalling promote effects acute traumatic facilitate exposure.

Language: Английский

Effects of Cannabis Use on Human Behavior, Including Cognition, Motivation, and Psychosis: A Review DOI
Nora D. Volkow, James M. Swanson, A. Eden Evins

et al.

JAMA Psychiatry, Journal Year: 2016, Volume and Issue: 73(3), P. 292 - 292

Published: Feb. 4, 2016

With a political debate about the potential risks and benefits of cannabis use as backdrop, wave legalization liberalization initiatives continues to spread. Four states (Colorado, Washington, Oregon, Alaska) District Columbia have passed laws that legalized for recreational by adults, 23 others plus now regulate medical purposes. These policy changes could trigger broad range unintended consequences, with profound lasting implications health social systems in our country. Cannabis is emerging one among many interacting factors can affect brain development mental function. To inform discourse scientific evidence, literature was reviewed identify what known not effects on human behavior, including cognition, motivation, psychosis.

Language: Английский

Citations

752
Endocannabinoid signalling in reward and addiction DOI

Loren H. Parsons,

Yasmin L. Hurd

Nature reviews. Neuroscience, Journal Year: 2015, Volume and Issue: 16(10), P. 579 - 594

Published: Sept. 16, 2015

Language: Английский

Citations

424
The cannabinoid system and pain DOI
Stephen G. Woodhams, Victoria Chapman, David P. Finn

et al.

Neuropharmacology, Journal Year: 2017, Volume and Issue: 124, P. 105 - 120

Published: June 16, 2017

Language: Английский

Citations

239
The endocannabinoid system as a target for novel anxiolytic drugs DOI
Sachin Patel,

Mathew N. Hill,

Joseph F. Cheer

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2017, Volume and Issue: 76, P. 56 - 66

Published: April 21, 2017

Language: Английский

Citations

222
The Role of the Endocannabinoid System in the Brain–Gut Axis DOI Open Access
Keith A. Sharkey, John Wiley

Gastroenterology, Journal Year: 2016, Volume and Issue: 151(2), P. 252 - 266

Published: April 30, 2016

Language: Английский

Citations

216
Integrating Endocannabinoid Signaling and Cannabinoids into the Biology and Treatment of Posttraumatic Stress Disorder DOI Open Access
Matthew N. Hill, Patrizia Campolongo, Rachel Yehuda

et al.

Neuropsychopharmacology, Journal Year: 2017, Volume and Issue: 43(1), P. 80 - 102

Published: July 26, 2017

Language: Английский

Citations

203
The Role of the Endocannabinoid System and Genetic Variation in Adolescent Brain Development DOI Open Access
Heidi C. Meyer, Francis S. Lee, Dylan G. Gee

et al.

Neuropsychopharmacology, Journal Year: 2017, Volume and Issue: 43(1), P. 21 - 33

Published: July 7, 2017

Language: Английский

Citations

190
Reviewing the Potential of Psychedelics for the Treatment of PTSD DOI Creative Commons

Erwin Krediet,

Tijmen Bostoen,

Joost J. Breeksema

et al.

The International Journal of Neuropsychopharmacology, Journal Year: 2020, Volume and Issue: 23(6), P. 385 - 400

Published: March 12, 2020

There are few medications with demonstrated efficacy for the treatment of posttraumatic stress disorder (PTSD). Treatment guidelines have unequivocally designated psychotherapy as a first line PTSD. Yet, even after psychotherapy, PTSD often remains chronic illness, high rates psychiatric and medical comorbidity. Meanwhile, search development drugs new mechanisms action has stalled. Therefore, there is an urgent need to explore not just novel compounds but approaches A promising approach involves use psychedelic drugs. Within past years, 2 psychedelics received breakthrough designations indications from US Food Drug Administration, several currently being investigated This review discusses 4 types compounds: 3,4-methylenedioxymethamphetamine, ketamine, classical (e.g., psilocybin lysergic acid diethylamide), cannabinoids. We describe therapeutic rationale, setting in which they administered, their current state evidence Each compound provides unique qualities PTSD, rapidly target symptoms adjuncts facilitate psychotherapeutic treatments. Several questions formulated that outline agenda future research.

Language: Английский

Citations

190
2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain DOI Creative Commons
Marc P. Baggelaar, Mauro Maccarrone, Mario van der Stelt

et al.

Progress in Lipid Research, Journal Year: 2018, Volume and Issue: 71, P. 1 - 17

Published: May 8, 2018

2-Arachidonoylglycerol (2-AG) is a signaling lipid in the central nervous system that key regulator of neurotransmitter release. 2-AG an endocannabinoid activates cannabinoid CB1 receptor. It involved wide array (patho)physiological functions, such as emotion, cognition, energy balance, pain sensation and neuroinflammation. In this review, we describe biosynthetic metabolic pathways how chemical genetic perturbation these has led to insight biological role lipid. Finally, discuss potential therapeutic benefits modulating levels brain.

Language: Английский

Citations

189
Elevated Anandamide, Enhanced Recall of Fear Extinction, and Attenuated Stress Responses Following Inhibition of Fatty Acid Amide Hydrolase: A Randomized, Controlled Experimental Medicine Trial DOI Creative Commons
Leah M. Mayo, Anna Asratian,

Johan Lindé

et al.

Biological Psychiatry, Journal Year: 2019, Volume and Issue: 87(6), P. 538 - 547

Published: Aug. 13, 2019

BackgroundPosttraumatic stress disorder, an area of large unmet medical needs, is characterized by persistence fear memories and maladaptive responses. In rodents, elevation the endocannabinoid anandamide due to inhibition fatty acid amide hydrolase (FAAH) facilitates extinction protects against anxiogenic effects stress. We recently reported that elevated levels in people homozygous for a loss-of-function FAAH mutation are associated with similar phenotype, suggesting translational validity preclinical findings.MethodsIn this double-blind, placebo-controlled experimental medicine study, healthy adults were randomized inhibitor (PF-04457845, 4 mg orally, once daily; n = 16) or placebo (n 29) 10 days. On days 9 10, participants completed task battery assessing psychophysiological indices learning, reactivity, stress-induced affective responses.ResultsFAAH produced 10-fold increase baseline anandamide. This was potentiated recall memory when tested 24 hours after training. also attenuated autonomic assessed via electrodermal activity, protected negative affect, measured facial electromyography.ConclusionsOur data provide preliminary human evidence can improve attenuate stress, direct translation rodent findings. The beneficial on extinction, as well stress- affect-related behaviors, strong rationale developing drug class treatment posttraumatic disorder.

Language: Английский

Citations

183