A guide to cancer immunotherapy: from T cell basic science to clinical practice

Nature reviews. Immunology, Год журнала: 2020, Номер 20(11), С. 651 - 668

Опубликована: Май 20, 2020

Язык: Английский

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Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

Cell, Год журнала: 2019, Номер 177(2), С. 414 - 427.e13

Опубликована: Апрель 1, 2019

PD-L1 on the surface of tumor cells binds its receptor PD-1 effector T cells, thereby suppressing their activity. Antibody blockade can activate an anti-tumor immune response leading to durable remissions in a subset cancer patients. Here, we describe alternative mechanism activity involving secretion tumor-derived exosomes. Removal exosomal inhibits growth, even models resistant anti-PD-L1 antibodies. Exosomal from suppresses cell activation draining lymph node. Systemically introduced rescues growth tumors unable secrete own. Exposure PD-L1-deficient wild-type injected at distant site, simultaneously or months later. Anti-PD-L1 antibodies work additively, not redundantly, with suppress growth. Together, these findings show that represents unexplored therapeutic target, which could overcome resistance current antibody approaches.

Язык: Английский

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Smart cancer nanomedicine

Nature Nanotechnology, Год журнала: 2019, Номер 14(11), С. 1007 - 1017

Опубликована: Ноя. 1, 2019

Язык: Английский

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Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

Journal of Hematology & Oncology, Год журнала: 2020, Номер 13(1)

Опубликована: Авг. 10, 2020

Abstract In recent years, cancer immunotherapy based on immune checkpoint inhibitors (ICIs) has achieved considerable success in the clinic. However, ICIs are significantly limited by fact that only one third of patients with most types respond to these agents. The induction cell death mechanisms other than apoptosis gradually emerged as a new treatment strategy because tumors harbor innate resistance apoptosis. date, possibility combining two modalities not been discussed systematically. Recently, few studies revealed crosstalk between distinct and antitumor immunity. pyroptosis, ferroptosis, necroptosis combined showed synergistically enhanced activity, even ICI-resistant tumors. Immunotherapy-activated CD8+ T cells traditionally believed induce tumor via following main pathways: (i) perforin-granzyme (ii) Fas-FasL. identified mechanism which suppress growth inducing ferroptosis provoked review relationship system activation. Hence, this review, we summarize knowledge reciprocal interaction immunity mechanisms, particularly necroptosis, three potentially novel immunogenic death. Because evidence is derived from using animal models, also reviewed related bioinformatics data available for human tissues public databases, partially confirmed presence interactions activation

Язык: Английский

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The lung microenvironment: an important regulator of tumour growth and metastasis

Nature reviews. Cancer, Год журнала: 2018, Номер 19(1), С. 9 - 31

Опубликована: Дек. 10, 2018

Язык: Английский

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Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

Journal for ImmunoTherapy of Cancer, Год журнала: 2020, Номер 8(1), С. e000337 - e000337

Опубликована: Март 1, 2020

Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular microenvironmental features determine the propensity of RCD drive immunity. Here, we provide updated operational definition immunogenic (ICD), discuss key factors that dictate ability dying cells response, summarize experimental assays are currently available for assessment ICD in vitro vivo, formulate guidelines their interpretation.

Язык: Английский

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Immunogenic cell stress and death

Nature Immunology, Год журнала: 2022, Номер 23(4), С. 487 - 500

Опубликована: Фев. 10, 2022

Язык: Английский

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Cancer nanomedicine for combination cancer immunotherapy

Nature Reviews Materials, Год журнала: 2019, Номер 4(6), С. 398 - 414

Опубликована: Апрель 26, 2019

Язык: Английский

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Detection of immunogenic cell death and its relevance for cancer therapy

Cell Death and Disease, Год журнала: 2020, Номер 11(11)

Опубликована: Ноя. 26, 2020

Abstract Chemotherapy, radiation therapy, as well targeted anticancer agents can induce clinically relevant tumor-targeting immune responses, which critically rely on the antigenicity of malignant cells and their capacity to generate adjuvant signals. In particular, immunogenic cell death (ICD) is accompanied by exposure release numerous damage-associated molecular patterns (DAMPs), altogether confer a robust adjuvanticity dying cancer cells, they favor recruitment activation antigen-presenting cells. ICD-associated DAMPs include surface-exposed calreticulin (CALR) secreted ATP, annexin A1 (ANXA1), type I interferon, high-mobility group box 1 (HMGB1). Additional hallmarks ICD encompass phosphorylation eukaryotic translation initiation factor 2 subunit-α (EIF2S1, better known eIF2α), autophagy, global arrest in transcription translation. Here, we outline methodological approaches for measuring markers vitro ex vivo discovery next-generation antineoplastic agents, development personalized regimens, identification optimal therapeutic combinations clinical management cancer.

Язык: Английский

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Radiotherapy toxicity

Nature Reviews Disease Primers, Год журнала: 2019, Номер 5(1)

Опубликована: Фев. 21, 2019

Язык: Английский

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