Nature Communications,
Год журнала:
2017,
Номер
8(1)
Опубликована: Ноя. 20, 2017
Abstract
The
delivery
of
therapeutic
peptides
for
diabetes
therapy
is
compromised
by
short
half-lives
drugs
with
the
consequent
need
multiple
daily
injections
that
reduce
patient
compliance
and
increase
treatment
cost.
In
this
study,
we
demonstrate
a
smart
exendin-4
(Ex4)
device
based
on
microneedle
(MN)-array
patches
integrated
dual
mineralized
particles
separately
containing
Ex4
glucose
oxidase
(GOx).
particle-based
system
can
specifically
release
while
immobilizing
GOx
as
result
differential
response
to
microenvironment
induced
biological
stimuli.
manner,
enables
glucose-responsive
closed-loop
significantly
improve
performance.
Moreover,
integration
enhance
mechanical
strength
alginate-based
MN
crosslinking
facilitate
skin
penetration,
thus
supporting
painless
non-invasive
transdermal
administration.
We
believe
holds
great
promise
type
2
providing
safe,
long-term,
on-demand
therapy.
Frontiers in Physiology,
Год журнала:
2018,
Номер
9
Опубликована: Май 1, 2018
Macrophages
play
key
roles
in
all
phases
of
adult
wound
healing,
which
are
inflammation,
proliferation
and
remodeling.
As
wounds
heal,
the
local
macrophage
population
transitions
from
predominantly
pro-inflammatory
(M1-like
phenotypes)
to
anti-inflammatory
(M2-like
phenotypes).
Non-healing
chronic
wounds,
such
as
pressure,
arterial,
venous
diabetic
ulcers
indefinitely
remain
inflammation—the
first
stage
healing.
Thus,
macrophages
retain
characteristics.
This
review
discusses
physiology
monocytes
acute
healing
different
phenotypes
described
literature
for
both
vitro
vivo
models.
We
also
discuss
aberrations
that
occur
populations
attempts
restore
function
by
therapeutic
approaches.
These
include
endogenous
M1
attenuation,
exogenous
M2
supplementation
modulation/M2
promotion
via
mesenchymal
stem
cells,
growth
factors,
biomaterials,
heme
oxygenase-1
(HO-1)
expression
oxygen
therapy.
recognize
challenges
controversies
exist
this
field,
standardization
phenotype
nomenclature,
definition
their
distinct
understanding
is
optimal
order
promote
wounds.
Science,
Год журнала:
2014,
Номер
346(6212), С. 954 - 959
Опубликована: Ноя. 20, 2014
Human
skin,
the
body's
largest
organ,
functions
as
a
physical
barrier
to
bar
entry
of
foreign
pathogens,
while
concomitantly
providing
home
myriad
commensals.
Over
human's
life
span,
keratinized
skin
cells,
immune
and
microbes
all
interact
integrate
processes
maintaining
skin's
under
homeostatic
healthy
conditions
also
multiple
stresses,
such
wounding
or
infection.
In
this
Review,
we
explore
intricate
interactions
cells
on
surface
within
associated
appendages
regulate
orchestrated
maturation
in
context
both
host
physiological
changes
environmental
challenges.
International Journal of Inflammation,
Год журнала:
2019,
Номер
2019, С. 1 - 15
Опубликована: Июнь 2, 2019
Experimental
work
of
the
last
two
decades
has
revealed
general
steps
wound
healing
process.
This
complex
network
been
organized
in
three
sequential
and
overlapping
steps.
The
first
step
inflammatory
phase
is
an
immediate
response
to
injury;
primary
sensory
neurons
sense
injury
send
danger
signals
brain,
stop
bleeding
start
inflammation.
following
target
phase,
led
by
peripheral
blood
mononuclear
cells,
eliminate
pathogens
clean
wound.
Once
this
completed,
resolved
homeostasis
restored.
aim
proliferative
second
repair
damage
begin
tissue
remodeling.
Fibroplasia,
reepithelialization,
angiogenesis,
nerve
are
central
actions
phase.
Lastly,
objective
final
complete
remodeling
restore
skin
integrity.
review
provides
present
day
information
regarding
status
participant
extracellular
matrix,
cytokines,
chemokines,
growth
factors,
as
well
their
interactions
with
microenvironment
during
Immunity,
Год журнала:
2017,
Номер
46(2), С. 287 - 300
Опубликована: Фев. 1, 2017
Tissue-resident
memory
T
(Trm)
cells
form
a
heterogeneous
population
that
provides
localized
protection
against
pathogens.
Here,
we
identify
CD49a
as
marker
differentiates
CD8+
Trm
on
compartmental
and
functional
basis.
In
human
skin
epithelia,
CD8+CD49a+
produced
interferon-γ,
whereas
CD8+CD49a−
interleukin-17
(IL-17).
addition,
from
healthy
rapidly
induced
the
expression
of
effector
molecules
perforin
granzyme
B
when
stimulated
with
IL-15,
thereby
promoting
strong
cytotoxic
response.
patients
vitiligo,
where
melanocytes
are
eradicated
locally,
constitutively
expressed
accumulated
both
in
epidermis
dermis.
Conversely,
CD8+CD49a–
psoriasis
lesions
predominantly
generated
IL-17
responses
promote
local
inflammation
this
disease.
Overall,
delineates
cell
specialization
epithelial
barriers
correlates
balance
found
distinct
inflammatory
diseases.
International Journal of Molecular Sciences,
Год журнала:
2019,
Номер
20(8), С. 1811 - 1811
Опубликована: Апрель 12, 2019
The
skin
is
a
complex
organ
that
has
devised
numerous
strategies,
such
as
physical,
chemical,
and
microbiological
barriers,
to
protect
the
host
from
external
insults.
In
addition,
contains
an
intricate
network
of
immune
cells
resident
tissue,
crucial
for
defense
well
tissue
homeostasis.
event
insult,
skin-resident
are
not
only
prevention
infection
but
also
reconstruction.
Deregulation
responses
often
leads
impaired
healing
poor
restoration
function.
this
review,
we
will
discuss
defensive
components
focus
on
function
in
homeostasis
their
role
wound
healing.
Stem Cell Research & Therapy,
Год журнала:
2019,
Номер
10(1)
Опубликована: Март 29, 2019
Normal
wound
healing
is
a
dynamic
and
complex
multiple
phase
process
involving
coordinated
interactions
between
growth
factors,
cytokines,
chemokines,
various
cells.
Any
failure
in
these
phases
may
lead
wounds
to
become
chronic
have
abnormal
scar
formation.
Chronic
affect
patients'
quality
of
life,
since
they
require
repetitive
treatments
incur
considerable
medical
costs.
Thus,
much
effort
has
been
focused
on
developing
novel
therapeutic
approaches
for
treatment.
Stem-cell-based
strategies
proposed
treat
wounds.
They
shown
potential
improving
the
rate
regenerating
skin.
However,
there
are
many
challenges
using
stem
cells
skin
regeneration.
In
this
review,
we
present
some
sets
data
published
embryonic
cells,
induced
pluripotent
adult
Additionally,
will
discuss
different
angles
whereby
can
contribute
their
unique
features
show
current
drawbacks.
International Immunology,
Год журнала:
2015,
Номер
27(6), С. 269 - 280
Опубликована: Март 26, 2015
The
skin
is
the
largest
organ
of
mammalian
body.
outermost
layer
skin,
stratum
corneum
(SC)
epidermis,
consists
piles
dead
corneocytes
that
are
end-products
terminal
differentiation
epidermal
keratinocytes.
SC
performs
a
crucial
barrier
function
epidermis.
Langerhans
cells,
when
activated,
extend
their
dendrites
through
tight
junctions
just
beneath
to
capture
external
antigens.
Recently,
knowledge
biology
('corneobiology')
has
progressed
rapidly
and
many
key
factors
modulate
its
have
been
identified
characterized.
In
this
review
article
on
SC,
we
summarize
evolution,
formation,
structure
function.
Cornification
an
important
step
formation
at
conversion
living
epithelial
cells
corneocytes,
three
major
steps:
intracellular
keratin
network,
cornified
envelopes
intercellular
lipids.
After
cornification,
undergoes
chemical
reactions
form
mature
with
different
functional
layers.
Finally,
shed
off
surface
('desquamation'),
mediated
by
cascade
several
proteases.
This
will
be
helpful
understand
our
expanding
where
immunity
meets
