Chronic wounds

Nature Reviews Disease Primers, Год журнала: 2022, Номер 8(1)

Опубликована: Июль 21, 2022

Язык: Английский

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Enhancement strategies for transdermal drug delivery systems: current trends and applications

Drug Delivery and Translational Research, Год журнала: 2021, Номер 12(4), С. 758 - 791

Опубликована: Янв. 20, 2021

Abstract Transdermal drug delivery systems have become an intriguing research topic in pharmaceutical technology area and one of the most frequently developed products global market. The use these can overcome associated drawbacks other routes, such as oral parenteral. authors will review current trends, future applications transdermal technologies, with specific focus on providing a comprehensive understanding enhancement strategies. This article initially discuss each method used development first-generation products. These methods include drug/vehicle interactions, vesicles particles, stratum corneum modification, energy-driven bypassing techniques. Through suitable design implementation active methods, notably microneedle technology, been shown to deliver both low high molecular weight drugs. Microneedle platforms proven themselves be more versatile than opportunities for intradermal drugs/biotherapeutics therapeutic monitoring. that microneedles prospective strategy improving systems. Graphical abstract

Язык: Английский

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Macrophages as a therapeutic target to promote diabetic wound healing

Molecular Therapy, Год журнала: 2022, Номер 30(9), С. 2891 - 2908

Опубликована: Авг. 2, 2022

It is well‏ ‏established that macrophages are key regulators of wound healing, displaying impressive plasticity and an evolving phenotype, from aggressive pro-inflammatory or "M1" phenotype to a pro-healing "M2" depending on the healing stage, ensure proper healing. Because dysregulated macrophage responses have been linked impaired diabetic wounds, being considered as therapeutic target for improved In this review, we first discuss role in normal skin process aberrations occur under conditions. Next provide overview recent macrophage-based approaches, including delivery ex-vivo-activated pharmacological strategies aimed at eliminating re-educating local macrophages. particular, focus silence regulator genes repolarize M2 discussion their potential future clinical translation.

Язык: Английский

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Cytokinocytes: the diverse contribution of keratinocytes to immune responses in skin

JCI Insight, Год журнала: 2020, Номер 5(20)

Опубликована: Окт. 14, 2020

The skin serves as the primary interface between our body and external environment acts a barrier against entry of physical agents, chemicals, microbes. Keratinocytes make up main cellular constitute outermost layer skin, contributing to formation epidermis, they are crucial for maintaining integrity this barrier. Beyond serving component, keratinocytes actively participate in tissue homeostasis, shaping, amplifying, regulating immune responses skin. act sentinels, continuously monitoring changes environment, and, through microbial sensing, stretch, or other stimuli, can initiate broad range inflammatory via secretion various cytokines, chemokines, growth factors. This diverse function contributes highly variable clinical manifestation responses. In Review, we highlight functions epidermal their contribution immune-mediated diseases.

Язык: Английский

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The role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity

Military Medical Research, Год журнала: 2022, Номер 9(1)

Опубликована: Ноя. 19, 2022

Abstract Bone, cartilage, and soft tissue regeneration is a complex spatiotemporal process recruiting variety of cell types, whose activity interplay must be precisely mediated for effective healing post-injury. Although extensive strides have been made in the understanding immune microenvironment processes governing bone, regeneration, clinical translation these mechanisms remains challenge. Regulation increasingly becoming favorable target regeneration; therefore, an in-depth communication between cells functional would valuable. Herein, we review regulatory role promotion maintenance stem states context repair regeneration. We discuss roles various subsets introduce novel strategies, example, biomaterial-targeting activity, aimed at regulating healing. Understanding crosstalk pathways may shed light on new therapeutic opportunities enhancing through regulation microenvironment.

Язык: Английский

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Applications of Mesenchymal Stem Cells in Skin Regeneration and Rejuvenation

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(5), С. 2410 - 2410

Опубликована: Фев. 27, 2021

Mesenchymal stem cells (MSCs) are multipotent derived from adult cells. Primary MSCs can be obtained diverse sources, including bone marrow, adipose tissue, and umbilical cord blood. Recently, have been recognized as therapeutic agents for skin regeneration rejuvenation. The damaged by wounds, caused cutting or breaking of the burns. Moreover, aging is a process that occurs naturally but worsened environmental pollution, exposure to ultraviolet radiation, alcohol consumption, tobacco use, undernourishment. healing capacities applied in aged skin. In regeneration, increase cell proliferation neovascularization, decrease inflammation injury lesions. rejuvenation, lead production collagen elastic fibers, inhibition metalloproteinase activation, promote protection radiation-induced senescence. this review, we focus on how MSC-derived molecules improve diseased Additionally, emphasize induced pluripotent (iPSC)-derived potentially advanced MSCs, which suitable therapy.

Язык: Английский

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Dopamine, Immunity, and Disease

Pharmacological Reviews, Год журнала: 2022, Номер 75(1), С. 62 - 158

Опубликована: Дек. 8, 2022

The neurotransmitter dopamine is a key factor in central nervous system (CNS) function, regulating many processes including reward, movement, and cognition. Dopamine also regulates critical functions peripheral organs, such as blood pressure, renal activity, intestinal motility. Beyond these functions, growing body of evidence indicates that an important immunoregulatory factor. Most types immune cells express receptors other dopaminergic proteins, take up, produce, store, and/or release dopamine, suggesting immunomodulation for function. Targeting pathways could be promising avenue the treatment inflammation disease, but despite increasing research this area, data on specific effects disease remain inconsistent poorly understood. Therefore, review integrates current knowledge role cell function inflammatory signaling across systems. We discuss understanding regulation CNS tissues, highlighting diseases Parkinson’s several neuropsychiatric conditions, neurologic human immunodeficiency virus, bowel rheumatoid arthritis, others. Careful consideration given to influence experimental design results, we note number areas need further research. Overall, our immunology at cellular, tissue, level prompts development therapeutics strategies targeted toward ameliorating through immunity.

Significance Statement

Canonically, recognized involved cognition, reward. However, acts modulator periphery. This comprehensively assesses pathogenesis cellular tissue level. will provide broad access information fields, identify investigation, drive therapeutic strategies.

Язык: Английский

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Chronic Inflammation in Non-Healing Skin Wounds and Promising Natural Bioactive Compounds Treatment

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(9), С. 4928 - 4928

Опубликована: Апрель 28, 2022

Chronic inflammation is one of the hallmarks chronic wounds and tightly coupled to immune regulation. The dysregulation system leads continuing impaired wound healing and, subsequently, skin wounds. In this review, we discuss role system, involvement inflammatory mediators reactive oxygen species, complication bacterial infections in healing, still-underexplored potential natural bioactive compounds treatment. We focus on with antioxidant, anti-inflammatory, antibacterial activities their mechanisms action, as well recent treatments therapeutic advancements capitalizing nanotechnology or new biomaterial platforms.

Язык: Английский

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Biofilm-Innate Immune Interface: Contribution to Chronic Wound Formation

Frontiers in Immunology, Год журнала: 2021, Номер 12

Опубликована: Апрель 9, 2021

Delayed wound healing can cause significant issues for immobile and ageing individuals as well those living with co-morbid conditions such diabetes, cardiovascular disease, cancer. These delays increase a patient’s risk infection and, in severe cases, result the formation of chronic, non-healing ulcers (e.g., diabetic foot ulcers, surgical site infections, pressure venous leg ulcers). Chronic wounds are very difficult expensive to treat there is an urgent need develop more effective therapeutics that restore processes. Sustained innate immune activation inflammation common features observed across most chronic types. However, factors driving this remain incompletely understood. Emerging evidence suggests composition structure microbiome may play central role dysregulated but cellular molecular mechanisms underlying these processes require further investigation. In review, we will discuss current literature on: 1) how bacterial populations biofilms contribute formation, 2) bacteria dysfunctional responses wounds, 3) currently available (or underdevelopment) target bacteria-innate interactions improve healing. We also potential studying complexity immune-biofilm explore future areas investigation field.

Язык: Английский

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Deep-Learning Enabled Active Biomimetic Multifunctional Hydrogel Electronic Skin

ACS Nano, Год журнала: 2023, Номер 17(16), С. 16160 - 16173

Опубликована: Июль 31, 2023

There is huge demand for recreating human skin with the functions of epidermis and dermis interactions physical world. Herein, a biomimetic, ultrasensitive, multifunctional hydrogel-based electronic (BHES) was proposed. Its function mimicked using poly(ethylene terephthalate) nanoscale wrinkles, enabling accurate identification materials through capabilities to gain/lose electrons during contact electrification. Internal mechanoreceptor by interdigital silver electrodes stick–slip sensing identify textures/roughness. The patterned microcone hydrogel, achieving pressure sensors high sensitivity (17.32 mV/Pa), large range (20–5000 Pa), low detection limit, fast response (10 ms)/recovery time (17 ms). Assisted deep learning, this BHES achieved accuracy minimized interference in identifying (95.00% 10 materials) textures (97.20% four roughness cases). By integrating signal acquisition/processing circuits, wearable drone control system demonstrated three-degree-of-freedom movement enormous potentials soft robots, self-powered human–machine interaction interfaces digital twins.

Язык: Английский

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