Journal of Biomedical Science,
Год журнала:
2019,
Номер
26(1)
Опубликована: Янв. 3, 2019
Gut
microbiota
interacting
with
an
intact
mucosal
surface
are
key
to
the
maintenance
of
homeostasis
and
health.
This
review
discusses
current
state
knowledge
biofilm
mode
growth
these
communities,
how
in
turn
their
disruptions
may
cause
disease.
Beyond
alterations
relative
microbial
abundance
diversity,
aim
is
focus
on
structure
function,
dispersion
commensal
bacteria,
mechanisms
whereby
dispersed
commensals
become
pathobionts.
Recent
findings
have
linked
iron
acquisition
expression
virulence
factors
gut
that
Causal
studies
emerging,
common
enteropathogen-induced
disruptions,
as
well
those
reported
for
Inflammatory
Bowel
Disease
colo-rectal
cancer
used
examples
illustrate
great
translational
potential
such
research.
These
new
observations
shed
light
our
attempts
develop
therapies
able
protect
restore
many
disease
conditions
been
dysbiosis.
European Heart Journal,
Год журнала:
2018,
Номер
40(7), С. 583 - 594
Опубликована: Ноя. 19, 2018
Carnitine
and
choline
are
major
nutrient
precursors
for
gut
microbiota-dependent
generation
of
the
atherogenic
metabolite,
trimethylamine
N-oxide
(TMAO).
We
performed
randomized-controlled
dietary
intervention
studies
to
explore
impact
chronic
patterns
on
TMAO
levels,
metabolism
renal
excretion.
Nutrients,
Год журнала:
2021,
Номер
14(1), С. 166 - 166
Опубликована: Дек. 30, 2021
The
gut
microbiota
has
been
linked
to
the
emergence
of
obesity,
metabolic
syndrome
and
onset
type
2
diabetes
through
decreased
glucose
tolerance
insulin
resistance.
Uncontrolled
can
lead
serious
health
consequences
such
as
impaired
kidney
function,
blindness,
stroke,
myocardial
infarction
lower
limb
amputation.
Despite
a
variety
treatments
currently
available,
cases
resulting
complications
are
on
rise.
One
promising
new
approach
focuses
modulating
with
probiotics,
prebiotics,
synbiotics
fecal
microbial
transplantation.
Differences
in
composition
have
observed
preclinical
animal
models
well
patients
diabetic
nephropathy,
retinopathy,
neuropathy,
cerebrovascular
disease,
coronary
heart
disease
peripheral
artery
compared
healthy
controls.
Severity
dysbiosis
was
associated
severity
restoration
probiotic
administration
human
improvement
symptoms
progression.
Characterizing
different
diseases
determining
causal
relationship
between
be
beneficial
formulating
therapeutic
interventions
for
complications.
In
this
review,
we
present
most
important
findings
regarding
role
chronic
their
underlying
mechanisms.
Biomolecules,
Год журнала:
2020,
Номер
10(2), С. 291 - 291
Опубликована: Фев. 13, 2020
Obesity
is
characterized
by
the
excessive
deposition
of
fat
that
may
interfere
with
normal
metabolic
process
body.
It
a
chronic
condition
associated
various
syndromes,
whose
prevalence
grossly
increasing,
and
affects
both
children
adults.
Accumulation
macronutrients
on
adipose
tissues
promotes
secretion
release
inflammatory
mediators,
including
interleukin-6
(IL-6),
interleukin
1β,
tumor
necrotic
factor-α
(TNF-α),
leptin,
stimulation
monocyte
chemoattractant
protein-1
(MCP-1),
which
subsequently
reduce
production
adiponectin
thereby
initiating
proinflammatory
state.
During
obesity,
tissue
synthesizes
releases
large
number
hormones
cytokines
alter
processes,
profound
influence
endothelial
dysfunction,
situation
formation
atherosclerotic
plaque.
Endothelial
cells
respond
to
inflammation
MCP-1,
described
as
activation
adhesion
molecules
leading
proliferation
transmigration
leukocytes,
facilitates
their
increase
in
atherogenic
thromboembolic
potentials.
dysfunction
forms
cornerstone
this
discussion,
it
has
been
considered
initiator
progression
cardiovascular
diseases
obesity.
Overexpression
subsequent
reduction
anti-inflammatory
markers
be
link
between
obesity-induced
dysfunction.
Inhibition
mechanisms
management
control
obesity
can
assist
reducing
risks
complications.
European Heart Journal,
Год журнала:
2020,
Номер
41(31), С. 2974 - 2982
Опубликована: Янв. 9, 2020
Abstract
The
ongoing
worldwide
increase
in
life
expectancy
portends
a
rising
prevalence
of
age-related
cardiovascular
(CV)
diseases
the
coming
decades
that
demands
deeper
understanding
their
molecular
mechanisms.
Inflammation
has
recently
emerged
as
an
important
contributor
for
CV
disease
development.
Indeed,
state
chronic
sterile
low-grade
inflammation
characterizes
older
organisms
(also
known
inflamm-ageing)
and
participates
pivotally
development
frailty,
disability,
most
degenerative
including
cerebrovascular
afflictions.
Due
to
activation
inflammasomes
reduced
endogenous
anti-inflammatory
mechanisms,
inflamm-ageing
contributes
leucocytes,
endothelial,
vascular
smooth
muscle
cells,
thus
accelerating
ageing
atherosclerosis.
Furthermore,
promotes
catastrophic
athero-thrombotic
complications
by
enhancing
platelet
reactivity
predisposing
plaque
rupture
erosion.
Thus,
its
contributors
or
mediators
might
furnish
targets
novel
therapeutic
strategies
could
promote
healthy
conserve
resources
health
care
systems
worldwide.
Here,
we
discuss
recent
findings
pathophysiology
inflamm-ageing,
impact
these
processes
on
diseases,
results
from
clinical
trials
targeting
components
potential
implementation
advances
into
daily
practice.
International Journal of Microbiology,
Год журнала:
2020,
Номер
2020, С. 1 - 13
Опубликована: Май 22, 2020
Microbes
are
found
all
over
the
globe
with
some
few
exceptions,
including
sterilized
surfaces.
They
include
normal
flora
that
is
nonpathogenic,
which
contribute
to
larger
percentage,
and
pathogenic
species
few.
Hence,
activities
of
humans
cannot
be
completely
separated
from
microbes.
Thus,
many
microbes
have
their
way
into
fresh
fruits
vegetables
a
great
source
healthy
diet
for
humans.
The
growing
demand
has
necessitated
production.
production
within
shortest
possible
time
meet
placed
them
at
higher
risk
contamination
microbes,
making
safety
consumers
uncertain.
Study
sources
type
etiological
agents
isolated
includes
Bacillus
cereus,
Campylobacter
jejuni,
Clostridium
botulinum,
E.
coli
O157:
H7,
Listeria
monocytogenes,
Salmonella
spp.,
Shigella,
Staphylococcus,
Vibrio
cholera.
Several
measures
proven
effective
in
controlling
they
establishment
surveillance
systems
monitor
chain
thoroughly
washing
vinegar
water.
Saltwater
other
techniques
but
caution
should
taken
make
sure
one
does
not
use
cycle
water
vegetables.
consumption
still
encouraged
by
this
review
significant
must
check
these
products
before
consumption.
Frontiers in Pharmacology,
Год журнала:
2018,
Номер
9
Опубликована: Сен. 25, 2018
In
recent
years,
accumulating
evidence
has
indicated
the
importance
of
gut
microbiota
in
maintaining
human
health.
Gut
dysbiosis
is
associated
with
pathogenesis
a
number
metabolic
diseases
including
obesity,
type
2
diabetes
mellitus
(T2DM),
nonalcoholic
fatty
liver
disease
(NAFLD)
and
cardiovascular
(CVD).
Indeed,
CVD
become
leading
cause
death
worldwide,
especially
developed
countries.
this
review,
we
mainly
discuss
microbiota-involved
mechanisms
focusing
on
atherosclerosis
hypertension,
two
major
risk
factors
for
serious
CVD.
Then,
briefly
prospects
microbiota-targeted
therapeutic
strategies
treatment
future.
