Characteristics and outcomes of patients hospitalized for COVID-19 and cardiac disease in Northern Italy

European Heart Journal, Год журнала: 2020, Номер 41(19), С. 1821 - 1829

Опубликована: Май 6, 2020

Abstract Aims To compare demographic characteristics, clinical presentation, and outcomes of patients with without concomitant cardiac disease, hospitalized for COVID-19 in Brescia, Lombardy, Italy. Methods results The study population includes 99 consecutive pneumonia admitted to our hospital between 4 March 25 2020. Fifty-three a history disease were compared 46 disease. Among patients, 40% had heart failure, 36% atrial fibrillation, 30% coronary artery Mean age was 67 ± 12 years, 80 (81%) males. No differences found non-cardiac except higher values serum creatinine, N-terminal probrain natriuretic peptide, high sensitivity troponin T patients. During hospitalization, 26% died, 15% developed thrombo-embolic events, 19% acute respiratory distress syndrome, 6% septic shock. Mortality the others (36% vs. 15%, log-rank P = 0.019; relative risk 2.35; 95% confidence interval 1.08–5.09). rate events shock during hospitalization also (23% 11% 0%, respectively). Conclusions Hospitalized have an extremely poor prognosis subjects mortality, rates.

Язык: Английский

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Malnutrition in Older Adults—Recent Advances and Remaining Challenges

Nutrients, Год журнала: 2021, Номер 13(8), С. 2764 - 2764

Опубликована: Авг. 12, 2021

Malnutrition in older adults has been recognised as a challenging health concern associated with not only increased mortality and morbidity, but also physical decline, which wide ranging acute implications for activities of daily living quality life general. is common may contribute to the development geriatric syndromes adults. old reflected by either involuntary weight loss or low body mass index, hidden deficiencies such micronutrient are more difficult assess therefore frequently overlooked community-dwelling old. In developed countries, most cited cause malnutrition disease, both chronic disorders have potential result aggravate malnutrition. Therefore, higher age one risk factor developing highest being at nutritional becoming malnourished. However, aetiology complex multifactorial, likely facilitated ageing processes. This comprehensive narrative review summarizes current evidence on prevalence determinants spanning from age-related changes disease-associated factors, outlines remaining challenges understanding, identification well treatment malnutrition, some cases include targeted supplementation macro- and/or micronutrients, when diet alone sufficient meet age-specific requirements.

Язык: Английский

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Inflammation, Aging, and Cardiovascular Disease

Journal of the American College of Cardiology, Год журнала: 2022, Номер 79(8), С. 837 - 847

Опубликована: Фев. 21, 2022

Язык: Английский

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The role of cellular senescence in cardiac disease: basic biology and clinical relevance

Nature Reviews Cardiology, Год журнала: 2021, Номер 19(4), С. 250 - 264

Опубликована: Окт. 19, 2021

Язык: Английский

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Effect of Physical Activity/Exercise on Oxidative Stress and Inflammation in Muscle and Vascular Aging

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(15), С. 8713 - 8713

Опубликована: Авг. 5, 2022

Functional status is considered the main determinant of healthy aging. Impairment in skeletal muscle and cardiovascular system, two interrelated systems, results compromised functional Increased oxidative stress inflammation older subjects constitute background for system alterations. Aged mass strength impairment related to anabolic resistance, mitochondrial dysfunction, increased as well a reduced antioxidant response myokine profile. Arterial stiffness endothelial function stand out alterations aging, where systemic vascular play key role. Physical activity exercise training arise modifiable determinants outcomes persons. Exercise enhances response, decreases age-related pro-inflammatory signals, promotes activation biogenesis pathways muscle. Additionally, improves arterial by reducing inflammatory damage signaling tissue together with an increase enzymes nitric oxide availability, globally promoting performance This review focuses on role aged musculoskeletal systems how physical activity/exercise influences elderly.

Язык: Английский

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Metabolic inflammation in heart failure with preserved ejection fraction

Cardiovascular Research, Год журнала: 2020, Номер 117(2), С. 423 - 434

Опубликована: Июль 7, 2020

Abstract One in 10 persons the world aged 40 years and older will develop syndrome of HFpEF (heart failure with preserved ejection fraction), most common form chronic cardiovascular disease for which no effective therapies are currently available. Metabolic disturbance inflammatory burden contribute importantly to pathogenesis. The interplay within these two biological processes is complex; indeed, it now becoming clear that notion metabolic inflammation—metainflammation—must be considered central pathophysiology. Inflammation metabolism interact over course progression, likely impact treatment prevention. Here, we discuss evidence support a causal, mechanistic role metainflammation shaping HFpEF, proposing framework comorbidities profoundly cardiac pathways syndrome.

Язык: Английский

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Atherosclerosis and Inflammation: Insights from the Theory of General Pathological Processes

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(9), С. 7910 - 7910

Опубликована: Апрель 26, 2023

Recent advances have greatly improved our understanding of the molecular mechanisms behind atherosclerosis pathogenesis. However, there is still a need to systematize this data from general pathology perspective, particularly with regard atherogenesis patterns in context both canonical and non-classical inflammation types. In review, we analyze various typical phenomena outcomes cellular pro-inflammatory stress atherosclerosis, as well role endothelial dysfunction local systemic manifestations low-grade inflammation. We also present features immune development productive stable unstable plaques, along their similarities differences compared There are numerous factors that act inducers inflammatory process including vascular endothelium aging, metabolic dysfunctions, autoimmune, some cases, infectious damage factors. Life-critical complications such cardiogenic shock severe strokes, associated acute hyperinflammation. Additionally, critical atherosclerotic ischemia lower extremities induces paracoagulation chronic Conversely, sepsis, other conditions, diseases contribute atherogenesis. summary, can be characterized an independent form inflammation, sharing but having fundamental variants (classic vasculitis).

Язык: Английский

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Inflammatory pathways in heart failure with preserved left ventricular ejection fraction: implications for future interventions

Cardiovascular Research, Год журнала: 2022, Номер 118(18), С. 3536 - 3555

Опубликована: Авг. 24, 2022

Abstract Many patients with symptoms and signs of heart failure have a left ventricular ejection fraction ≥50%, termed preserved (HFpEF). HFpEF is heterogeneous syndrome mainly affecting older people who many other cardiac non-cardiac conditions that often cast doubt on the origin symptoms, such as breathlessness, or signs, peripheral oedema, rendering them neither sensitive nor specific to diagnosis HFpEF. Currently, management directed at controlling treating comorbid hypertension, atrial fibrillation, anaemia, coronary artery disease. also characterized by persistent increase in inflammatory biomarkers. Inflammation may be key driver development progression its associated comorbidities. Detailed characterization pathways provide insights into pathophysiology guide future management. There growing interest novel therapies specifically designed target deregulated inflammation therapeutic areas, including cardiovascular However, large-scale clinical trials investigating effectiveness anti-inflammatory treatments are still lacking. In this manuscript, we review role possible implications for trials.

Язык: Английский

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Targeting senescent cells for a healthier longevity: the roadmap for an era of global aging

Life Medicine, Год журнала: 2022, Номер 1(2), С. 103 - 119

Опубликована: Авг. 9, 2022

Abstract Aging is a natural but relentless process of physiological decline, leading to physical frailty, reduced ability respond stresses (resilience) and, ultimately, organismal death. Cellular senescence, self-defensive mechanism activated in response intrinsic stimuli and/or exogenous stress, one the central hallmarks aging. Senescent cells cease proliferate, while remaining metabolically active and secreting numerous extracellular factors, feature known as senescence-associated secretory phenotype. Senescence physiologically important for embryonic development, tissue repair, wound healing, prevents carcinogenesis. However, chronic accumulation persisting senescent contributes host pathologies including age-related morbidities. By paracrine endocrine mechanisms, can induce inflammation locally systemically, thereby causing dysfunction, organ degeneration. Agents those targeting damaging components phenotype or inducing apoptosis exhibit remarkable benefits both preclinical models early clinical trials geriatric conditions. Here we summarize features outline strategies holding potential be developed interventions. In long run, there an increasing demand safe, effective, clinically translatable senotherapeutics address healthcare needs current settings global

Язык: Английский

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Gut microbiota remodeling improves natural aging-related disorders through Akkermansia muciniphila and its derived acetic acid

Pharmacological Research, Год журнала: 2023, Номер 189, С. 106687 - 106687

Опубликована: Фев. 4, 2023

Accumulating evidence indicates gut microbiota contributes to aging-related disorders. However, the exact mechanism underlying dysbiosis-related pathophysiological changes during aging remains largely unclear. In current study, we first performed remodeling on old mice by fecal transplantation (FMT) from young mice, and then characterized bacteria signature that was specifically altered FMT. Our results revealed FMT significantly improved natural systemic disorders, particularly exerted hepatoprotective effects, glucose sensitivity, hepatosplenomegaly, inflammaging, antioxidative capacity intestinal barrier. Moreover, increased abundance of A.muciniphila, which almost nondetectable in mice. Interestingly, A.muciniphila supplementation also similar benefits with Notably, targeted metabolomics short chain fatty acids (SCFAs) only acetic acid consistently reversed Then, intervention beneficial actions both Caenorhabditis elegans conclusion, our study demonstrated disorders through its derived acid, suggesting interventions potent stimulative A. muciniphila growth production alternative effective way maintain healthy aging. The data RNAseq 16 S rRNA gene sequencing can be accessed NCBI accession number PRJNA848996 PRJNA849355.

Язык: Английский

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