Microbiome and Human Health: Current Understanding, Engineering, and Enabling Technologies DOI Creative Commons
Nikhil Aggarwal, Shohei Kitano,

Ginette Ru Ying Puah

и другие.

Chemical Reviews, Год журнала: 2022, Номер 123(1), С. 31 - 72

Опубликована: Ноя. 1, 2022

The human microbiome is composed of a collection dynamic microbial communities that inhabit various anatomical locations in the body. Accordingly, coevolution with host has resulted these playing profound role promoting health. Consequently, perturbations can cause or exacerbate several diseases. In this Review, we present our current understanding relationship between health and disease development, focusing on microbiomes found across digestive, respiratory, urinary, reproductive systems as well skin. We further discuss strategies by which composition function be modulated to exert therapeutic effect host. Finally, examine technologies such multiomics approaches cellular reprogramming microbes enable significant advancements research engineering.

Язык: Английский

Role of the gut microbiota in nutrition and health DOI Creative Commons
Ana M. Valdes, Jens Walter, Eran Segal

и другие.

BMJ, Год журнала: 2018, Номер unknown, С. k2179 - k2179

Опубликована: Июнь 13, 2018

Role of the gut microbiota in nutrition and healthAna M Valdes colleagues discuss strategies for modulating

Язык: Английский

Процитировано

1905

The pros, cons, and many unknowns of probiotics DOI
Jotham Suez, Niv Zmora, Eran Segal

и другие.

Nature Medicine, Год журнала: 2019, Номер 25(5), С. 716 - 729

Опубликована: Май 1, 2019

Язык: Английский

Процитировано

1048

Macronutrient metabolism by the human gut microbiome: major fermentation by-products and their impact on host health DOI Creative Commons
Kaitlyn Oliphant, Emma Allen‐Vercoe

Microbiome, Год журнала: 2019, Номер 7(1)

Опубликована: Июнь 13, 2019

The human gut microbiome is a critical component of digestion, breaking down complex carbohydrates, proteins, and to lesser extent fats that reach the lower gastrointestinal tract. This process results in multitude microbial metabolites can act both locally systemically (after being absorbed into bloodstream). impact these biochemicals on health complex, as potentially beneficial toxic be yielded from such pathways, some cases, effects are dependent upon metabolite concentration or organ locality. aim this review summarize our current knowledge how macronutrient metabolism by influences health. Metabolites discussed include short-chain fatty acids alcohols (mainly monosaccharides); ammonia, branched-chain acids, amines, sulfur compounds, phenols, indoles (derived amino acids); glycerol choline derivatives (obtained breakdown lipids); tertiary cycling carbon dioxide hydrogen. Key taxa related disease states will referred each case, gaps could contribute understanding overall wellness identified.

Язык: Английский

Процитировано

1017

The Human Gut Microbiome: From Association to Modulation DOI Creative Commons
Thomas Schmidt, Jeroen Raes, Peer Bork

и другие.

Cell, Год журнала: 2018, Номер 172(6), С. 1198 - 1215

Опубликована: Март 1, 2018

Язык: Английский

Процитировано

719

The double burden of malnutrition: aetiological pathways and consequences for health DOI
Jonathan C. K. Wells, Ana Lydia Sawaya, Rasmus Wibæk

и другие.

The Lancet, Год журнала: 2019, Номер 395(10217), С. 75 - 88

Опубликована: Дек. 15, 2019

Язык: Английский

Процитировано

700

Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration DOI Open Access
Emily R. Leeming, Abigail Johnson, Tim D. Spector

и другие.

Nutrients, Год журнала: 2019, Номер 11(12), С. 2862 - 2862

Опубликована: Ноя. 22, 2019

The human gut is inhabited by trillions of microorganisms composing a dynamic ecosystem implicated in health and disease. composition the microbiota unique to each individual tends remain relatively stable throughout life, yet daily transient fluctuations are observed. Diet key modifiable factor influencing microbiota, indicating potential for therapeutic dietary strategies manipulate microbial diversity, composition, stability. While diet can induce shift these changes appear be temporary. Whether prolonged permanent alterations unknown, mainly due lack long-term interventions, or follow-ups short-term interventions. It possible that habitual diets have greater influence on than acute strategies. This review presents current knowledge around response interventions identifies major factors contribute diet. Overall, further research include microbiome measures required before clinical recommendations made modulation health.

Язык: Английский

Процитировано

664

Human Gut Microbiome: Function Matters DOI
Anna Heintz‐Buschart, Paul Wilmes

Trends in Microbiology, Год журнала: 2017, Номер 26(7), С. 563 - 574

Опубликована: Ноя. 23, 2017

Язык: Английский

Процитировано

621

Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body DOI Creative Commons

Fernanda Cristofori,

Vanessa Nadia Dargenio, Costantino Dargenio

и другие.

Frontiers in Immunology, Год журнала: 2021, Номер 12

Опубликована: Фев. 26, 2021

Hosting millions of microorganisms, the digestive tract is primary and most important part bacterial colonization. On one side, in cases opportunistic invasion, abundant population inside intestinal tissues may face potential health problems such as inflammation infections. Therefore, immune system has evolved to sustain host–microbiota symbiotic relationship. other hand, maintain host homeostasis, microflora often exerts an immunoregulatory function that cannot be ignored. A field great interest association either microbiota or probiotics with concerning clinical uses. This microbial community regulates some host’s metabolic physiological functions drives early-life maturation, contributing their homeostasis throughout life. Changes gut can occur through modification function, composition (dysbiosis), microbiota–host interplays. Studies on animals humans show have a pivotal effect modulation inflammatory mechanisms; however, precise mechanisms not yet been well defined. Diet, age, BMI (body mass index), medications, stress confound benefits probiotic intake. In addition (permeability physiology), all these agents profound implications for microbiome composition. The use could improve population, increase mucus-secretion, prevent destruction tight junction proteins by decreasing number lipopolysaccharides (LPSs). When LPS binds endothelial cells toll-like receptors (TLR 2, 4), dendritic macrophage are activated, markers increased. Furthermore, decrease dysbiosis leakage after therapy minimize development biomarkers blunt unnecessary activation system. turn, differentiation T-cells against Th2 cytokines IL-4 IL-10. present narrative review explores interactions between microflora/probiotics starting from general perspective biological plausibility get vitro vivo demonstrations probiotic-based approach up possible uses novel therapeutic strategies.

Язык: Английский

Процитировано

575

The Gut Microbiota and Inflammation: An Overview DOI Open Access

Zahraa Al Bander,

Marloes Dekker Nitert, Aya Mousa

и другие.

International Journal of Environmental Research and Public Health, Год журнала: 2020, Номер 17(20), С. 7618 - 7618

Опубликована: Окт. 19, 2020

The gut microbiota encompasses a diverse community of bacteria that carry out various functions influencing the overall health host. These comprise nutrient metabolism, immune system regulation and natural defence against infection. presence certain is associated with inflammatory molecules may bring about inflammation in body tissues. Inflammation underlies many chronic multisystem conditions including obesity, atherosclerosis, type 2 diabetes mellitus bowel disease. be triggered by structural components which can result cascade pathways involving interleukins other cytokines. Similarly, by-products metabolic processes bacteria, some short-chain fatty acids, play role inhibiting processes. In this review, we aimed to provide an overview relationship between highlight relevant knowledge gaps field. Based on current literature, it appears as composition differs individuals contingent variety factors like diet genetics, possess pro-inflammatory effects whilst others harbour those anti-inflammatory effects. Recent technological advancements have allowed for better methods characterising microbiota. Further research continually improve our understanding interact elucidate reasons behind varying presentations same disease varied responses treatment different individuals. Furthermore, inform clinical practice microbes employed probiotic therapies or used identify suitable prebiotic therapies.

Язык: Английский

Процитировано

559

Gut Microbiota and Obesity: A Role for Probiotics DOI Open Access
Ludovico Abenavoli, Emidio Scarpellini, Carmela Colica

и другие.

Nutrients, Год журнала: 2019, Номер 11(11), С. 2690 - 2690

Опубликована: Ноя. 7, 2019

Nowadays, obesity is one of the most prevalent human health problems. Research from last 30 years has clarified role imbalance between energy intake and expenditure, unhealthy lifestyle, genetic variability in development obesity. More recently, composition metabolic functions gut microbiota have been proposed as being able to affect development. Here, we will report current knowledge on definition, composition, intestinal microbiota. We performed an extensive review literature, searching for following keywords: metabolism, microbiota, dysbiosis, There evidence association bacteria both infancy adults. are several genetic, metabolic, inflammatory pathophysiological mechanisms involved interplay microbes Microbial changes can be considered a factor humans. The modulation bacterial strains digestive tract help reshape profile obese host suggested by data animal studies. Thus, deep revision pertaining use probiotics, prebiotics, antibiotics patients conceivable

Язык: Английский

Процитировано

523