NeuroImage,
Год журнала:
2021,
Номер
247, С. 118788 - 118788
Опубликована: Дек. 12, 2021
We
present
both
a
scientific
overview
and
conceptual
positions
concerning
the
challenges
assets
of
electrophysiological
measurements
in
search
for
nature
functions
human
connectome.
discuss
how
field
has
been
inspired
by
findings
approaches
from
functional
magnetic
resonance
imaging
(fMRI)
informed
small
number
significant
multimodal
empirical
studies,
which
show
that
canonical
networks
are
commonplace
fMRI
fact
rooted
processes.
This
review
is
also
an
opportunity
to
produce
brief,
up-to-date
critical
survey
current
data
modalities
analytical
methods
available
deriving
static
dynamic
connectomes
electrophysiology.
hurdles
challenge
significance
impact
electrophysiology
connectome
research.
then
encourage
take
leap
faith
embrace
wealth
signals,
despite
their
apparent,
disconcerting
complexity.
Our
position
connectomics
poised
inform
testable
mechanistic
models
information
integration
hierarchical
brain
networks,
constructed
observable
oscillatory
aperiodic
signal
components
polyrhythmic
interactions.
Physiological Reviews,
Год журнала:
2020,
Номер
101(1), С. 259 - 301
Опубликована: Июнь 25, 2020
Neuropathic
pain
caused
by
a
lesion
or
disease
of
the
somatosensory
nervous
system
is
common
chronic
condition
with
major
impact
on
quality
life.
Examples
include
trigeminal
neuralgia,
painful
polyneuropathy,
postherpetic
and
central
poststroke
pain.
Most
patients
complain
an
ongoing
intermittent
spontaneous
of,
for
example,
burning,
pricking,
squeezing
quality,
which
may
be
accompanied
evoked
pain,
particular
to
light
touch
cold.
Ectopic
activity
in,
nerve-end
neuroma,
compressed
nerves
nerve
roots,
dorsal
root
ganglia,
thalamus
in
different
conditions
underlie
Evoked
spread
neighboring
areas,
underlying
pathophysiology
involves
peripheral
sensitization.
Maladaptive
structural
changes
number
cell-cell
interactions
molecular
signaling
sensitization
nociceptive
pathways.
These
alteration
ion
channels,
activation
immune
cells,
glial-derived
mediators,
epigenetic
regulation.
The
classes
therapeutics
drugs
acting
α
2
δ
subunits
calcium
sodium
descending
modulatory
inhibitory
Nature Communications,
Год журнала:
2018,
Номер
9(1)
Опубликована: Окт. 2, 2018
Abstract
Optogenetic
silencing
allows
time-resolved
functional
interrogation
of
defined
neuronal
populations.
However,
the
limitations
inhibitory
optogenetic
tools
impose
stringent
constraints
on
experimental
paradigms.
The
high
light
power
requirement
light-driven
ion
pumps
and
their
effects
intracellular
homeostasis
pose
unique
challenges,
particularly
in
experiments
that
demand
inhibition
a
widespread
population
vivo.
Guillardia
theta
anion-conducting
channelrhodopsins
(GtACRs)
are
promising
this
regard,
due
to
single-channel
conductance
favorable
photon-ion
stoichiometry.
GtACRs
show
poor
membrane
targeting
mammalian
cells,
activity
such
channels
can
cause
transient
excitation
axon
an
excitatory
chloride
reversal
potential
compartment.
Here,
we
address
these
problems
by
enhancing
subcellular
compartmentalization
GtACRs.
resulting
soma-targeted
improved
photocurrents,
reduced
axonal
sensitivity,
allowing
highly
efficient
brain.
From
biophysics
to
neuroscience
tools
The
channelrhodopsins
and
their
distinctive
light-activated
ion
channels
have
emerged
as
major
in
modern
biological
research.
Deisseroth
Hegemann
review
the
structural
functional
properties
of
these
protein
photoreceptors.
Mutagenesis
modeling
studies,
coupled
with
reintroduction
modified
into
living
systems,
offer
a
profound
understanding
how
work.
insights
underlying
basic
science
provide
foundations
for
developing
further
applications
biology
medicine.
Science
,
this
issue
p.
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