Astrocytes in chronic pain and itch DOI
Ru‐Rong Ji, Christopher R. Donnelly, Maiken Nedergaard

и другие.

Nature reviews. Neuroscience, Год журнала: 2019, Номер 20(11), С. 667 - 685

Опубликована: Сен. 19, 2019

Язык: Английский

Neurotoxic reactive astrocytes are induced by activated microglia DOI
Shane A. Liddelow, Kevin A. Guttenplan, Laura Clarke

и другие.

Nature, Год журнала: 2017, Номер 541(7638), С. 481 - 487

Опубликована: Янв. 1, 2017

Язык: Английский

Процитировано

6292

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse DOI Creative Commons
Ye Zhang, Steven A. Sloan, Laura Clarke

и другие.

Neuron, Год журнала: 2015, Номер 89(1), С. 37 - 53

Опубликована: Дек. 16, 2015

Язык: Английский

Процитировано

2060

Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes DOI Creative Commons
Hyuk Sung Kwon, Seong‐Ho Koh

Translational Neurodegeneration, Год журнала: 2020, Номер 9(1)

Опубликована: Ноя. 26, 2020

Abstract Neuroinflammation is associated with neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s and amyotrophic lateral sclerosis. Microglia astrocytes are key regulators of inflammatory responses in the central nervous system. The activation microglia heterogeneous traditionally categorized neurotoxic (M1-phenotype A1-phenotype astrocytes) or neuroprotective (M2-phenotype A2-phenotype astrocytes). However, this dichotomized classification may not reflect various phenotypes astrocytes. relationship between these activated glial cells also very complicated, phenotypic distribution can change, based on progression diseases. A better understanding roles diseases essential for developing effective therapies. In review, we discuss response focusing contributions their relationship. addition, biomarkers to measure neuroinflammation studies therapeutic drugs that modulate neuroinflammation.

Язык: Английский

Процитировано

1712

Microglia emerge as central players in brain disease DOI
Michael W. Salter, Beth Stevens

Nature Medicine, Год журнала: 2017, Номер 23(9), С. 1018 - 1027

Опубликована: Сен. 1, 2017

Язык: Английский

Процитировано

1485

Establishment and Dysfunction of the Blood-Brain Barrier DOI Creative Commons
Zhen Zhao, Amy R. Nelson, Christer Betsholtz

и другие.

Cell, Год журнала: 2015, Номер 163(5), С. 1064 - 1078

Опубликована: Ноя. 1, 2015

Язык: Английский

Процитировано

1399

A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity DOI Creative Commons

Hossam Kadry,

Behnam Noorani, Luca Cucullo

и другие.

Fluids and Barriers of the CNS, Год журнала: 2020, Номер 17(1)

Опубликована: Ноя. 18, 2020

Abstract The blood–brain barrier is playing a critical role in controlling the influx and efflux of biological substances essential for brain’s metabolic activity as well neuronal function. Thus, functional structural integrity BBB pivotal to maintain homeostasis brain microenvironment. different cells structures contributing developing this are summarized along with functions that plays at brain–blood interface. We also explained shear stress maintaining integrity. Furthermore, we elaborated on clinical aspects correlate between disruption neurological pathological conditions. Finally, discussed several biomarkers can help assess permeability in-vitro or in-vivo briefly explain their advantages disadvantages.

Язык: Английский

Процитировано

1171

Diversity of astrocyte functions and phenotypes in neural circuits DOI
Baljit S. Khakh, Michael V. Sofroniew

Nature Neuroscience, Год журнала: 2015, Номер 18(7), С. 942 - 952

Опубликована: Июнь 25, 2015

Язык: Английский

Процитировано

1066

Astrocyte barriers to neurotoxic inflammation DOI
Michael V. Sofroniew

Nature reviews. Neuroscience, Год журнала: 2015, Номер 16(5), С. 249 - 263

Опубликована: Апрель 20, 2015

Язык: Английский

Процитировано

1040

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease DOI Creative Commons
Tara L. Spires‐Jones, Bradley T. Hyman

Neuron, Год журнала: 2014, Номер 82(4), С. 756 - 771

Опубликована: Май 1, 2014

Язык: Английский

Процитировано

1037

Advancing the understanding of autism disease mechanisms through genetics DOI
Luis de la Torre-Ubieta, Hyejung Won, Jason L. Stein

и другие.

Nature Medicine, Год журнала: 2016, Номер 22(4), С. 345 - 361

Опубликована: Апрель 1, 2016

Язык: Английский

Процитировано

780