Neurotoxic reactive astrocytes are induced by activated microglia

Nature, Год журнала: 2017, Номер 541(7638), С. 481 - 487

Опубликована: Янв. 1, 2017

Язык: Английский

---

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

Neuron, Год журнала: 2015, Номер 89(1), С. 37 - 53

Опубликована: Дек. 16, 2015

Язык: Английский

---

Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes

Translational Neurodegeneration, Год журнала: 2020, Номер 9(1)

Опубликована: Ноя. 26, 2020

Abstract Neuroinflammation is associated with neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s and amyotrophic lateral sclerosis. Microglia astrocytes are key regulators of inflammatory responses in the central nervous system. The activation microglia heterogeneous traditionally categorized neurotoxic (M1-phenotype A1-phenotype astrocytes) or neuroprotective (M2-phenotype A2-phenotype astrocytes). However, this dichotomized classification may not reflect various phenotypes astrocytes. relationship between these activated glial cells also very complicated, phenotypic distribution can change, based on progression diseases. A better understanding roles diseases essential for developing effective therapies. In review, we discuss response focusing contributions their relationship. addition, biomarkers to measure neuroinflammation studies therapeutic drugs that modulate neuroinflammation.

Язык: Английский

---

Microglia emerge as central players in brain disease

Nature Medicine, Год журнала: 2017, Номер 23(9), С. 1018 - 1027

Опубликована: Сен. 1, 2017

Язык: Английский

---

Establishment and Dysfunction of the Blood-Brain Barrier

Cell, Год журнала: 2015, Номер 163(5), С. 1064 - 1078

Опубликована: Ноя. 1, 2015

Язык: Английский

---

A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity

Fluids and Barriers of the CNS, Год журнала: 2020, Номер 17(1)

Опубликована: Ноя. 18, 2020

Abstract The blood–brain barrier is playing a critical role in controlling the influx and efflux of biological substances essential for brain’s metabolic activity as well neuronal function. Thus, functional structural integrity BBB pivotal to maintain homeostasis brain microenvironment. different cells structures contributing developing this are summarized along with functions that plays at brain–blood interface. We also explained shear stress maintaining integrity. Furthermore, we elaborated on clinical aspects correlate between disruption neurological pathological conditions. Finally, discussed several biomarkers can help assess permeability in-vitro or in-vivo briefly explain their advantages disadvantages.

Язык: Английский

---

Diversity of astrocyte functions and phenotypes in neural circuits

Nature Neuroscience, Год журнала: 2015, Номер 18(7), С. 942 - 952

Опубликована: Июнь 25, 2015

Язык: Английский

---

Astrocyte barriers to neurotoxic inflammation

Nature reviews. Neuroscience, Год журнала: 2015, Номер 16(5), С. 249 - 263

Опубликована: Апрель 20, 2015

Язык: Английский

---

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

Neuron, Год журнала: 2014, Номер 82(4), С. 756 - 771

Опубликована: Май 1, 2014

Язык: Английский

---

Advancing the understanding of autism disease mechanisms through genetics

Nature Medicine, Год журнала: 2016, Номер 22(4), С. 345 - 361

Опубликована: Апрель 1, 2016

Язык: Английский

---