Neurotoxic reactive astrocytes are induced by activated microglia

Nature, Journal Year: 2017, Volume and Issue: 541(7638), P. 481 - 487

Published: Jan. 1, 2017

Language: Английский

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Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

Neuron, Journal Year: 2015, Volume and Issue: 89(1), P. 37 - 53

Published: Dec. 16, 2015

Language: Английский

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Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes

Translational Neurodegeneration, Journal Year: 2020, Volume and Issue: 9(1)

Published: Nov. 26, 2020

Abstract Neuroinflammation is associated with neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s and amyotrophic lateral sclerosis. Microglia astrocytes are key regulators of inflammatory responses in the central nervous system. The activation microglia heterogeneous traditionally categorized neurotoxic (M1-phenotype A1-phenotype astrocytes) or neuroprotective (M2-phenotype A2-phenotype astrocytes). However, this dichotomized classification may not reflect various phenotypes astrocytes. relationship between these activated glial cells also very complicated, phenotypic distribution can change, based on progression diseases. A better understanding roles diseases essential for developing effective therapies. In review, we discuss response focusing contributions their relationship. addition, biomarkers to measure neuroinflammation studies therapeutic drugs that modulate neuroinflammation.

Language: Английский

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Microglia emerge as central players in brain disease

Nature Medicine, Journal Year: 2017, Volume and Issue: 23(9), P. 1018 - 1027

Published: Sept. 1, 2017

Language: Английский

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Establishment and Dysfunction of the Blood-Brain Barrier

Cell, Journal Year: 2015, Volume and Issue: 163(5), P. 1064 - 1078

Published: Nov. 1, 2015

Language: Английский

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A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity

Fluids and Barriers of the CNS, Journal Year: 2020, Volume and Issue: 17(1)

Published: Nov. 18, 2020

Abstract The blood–brain barrier is playing a critical role in controlling the influx and efflux of biological substances essential for brain’s metabolic activity as well neuronal function. Thus, functional structural integrity BBB pivotal to maintain homeostasis brain microenvironment. different cells structures contributing developing this are summarized along with functions that plays at brain–blood interface. We also explained shear stress maintaining integrity. Furthermore, we elaborated on clinical aspects correlate between disruption neurological pathological conditions. Finally, discussed several biomarkers can help assess permeability in-vitro or in-vivo briefly explain their advantages disadvantages.

Language: Английский

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Diversity of astrocyte functions and phenotypes in neural circuits

Nature Neuroscience, Journal Year: 2015, Volume and Issue: 18(7), P. 942 - 952

Published: June 25, 2015

Language: Английский

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Astrocyte barriers to neurotoxic inflammation

Nature reviews. Neuroscience, Journal Year: 2015, Volume and Issue: 16(5), P. 249 - 263

Published: April 20, 2015

Language: Английский

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The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

Neuron, Journal Year: 2014, Volume and Issue: 82(4), P. 756 - 771

Published: May 1, 2014

Language: Английский

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Advancing the understanding of autism disease mechanisms through genetics

Nature Medicine, Journal Year: 2016, Volume and Issue: 22(4), P. 345 - 361

Published: April 1, 2016

Language: Английский

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