Toxicology Letters, Год журнала: 2023, Номер 391, С. 71 - 85
Опубликована: Дек. 14, 2023
Язык: Английский
Cells, Год журнала: 2022, Номер 11(22), С. 3567 - 3567
Опубликована: Ноя. 11, 2022
One of the most intriguing dogmas in neurosciences—the empirical lack brain neuronal regeneration adulthood onwards to late life—began be debunked initially by research groups focused on understanding postnatal (early days/weeks murine and guinea pigs) neurodevelopmental neuroplastic events [...]
Язык: Английский
Процитировано
9
Leukemia, Год журнала: 2023, Номер 37(4), С. 888 - 900
Опубликована: Фев. 15, 2023
Abstract Murine studies indicate that, after allogeneic haematopoietic stem cell transplantation (aHSCT), donor-derived macrophages replace damaged microglia and alloreactive T-cells invade the central nervous system (CNS). The clinical relevance of this is unknown. We assessed CNS immune surveillance metabolic activity involved in neuronal survival, relation to fatigue cognitive dysfunction 25 long-term survivors aHSCT. Patients with exhibited increased proportions activated CD16 + NK-cells cerebrospinal fluid (CSF). Immune activation was paralleled reduced levels anti-inflammatory factors T-cell suppression (transforming growth factor-β, programmed death ligand-1), NK-cell regulation (poliovirus receptor, nectin-2), macrophage (CD200, chemokine [C-X3-C motif] ligand-1). Additionally, CSF mRNA expression pattern associated neuroinflammation oxidative stress. Furthermore, proteomic, transcriptomic demonstrated decreased neuroprotective factors, an upregulation apoptosis pathway genes. kynurenine tryptophan metabolism all aHSCT patients, resulting accumulation neurotoxic pro-inflammatory metabolites. Cognitive decline are overlooked but frequent complications This study links post-transplant inflammation neurotoxicity our previously reported hypoactivation prefrontal cortex during testing, suggesting novel treatment targets.
Язык: Английский
Процитировано
4
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown
Опубликована: Авг. 22, 2023
ABSTRACT The human brain demonstrates structural and functional asymmetries which have implications for ageing mental neurological disease development. We used a set of magnetic resonance imaging (MRI) metrics derived from diffusion MRI data in N =48,040 UK Biobank participants to evaluate age-related differences asymmetry. Most regional grey white matter presented asymmetry, were higher later life. Informed by these results, we conducted hemispheric age (HBA) predictions left/right multimodal metrics. HBA was concordant conventional predictions, using both hemispheres, but offers supplemental general marker asymmetry when setting into relationship with each other. In contrast WM asymmetries, discrepancies are lower at ages. Our findings outline various sex-specific differences, particularly important estimates, the value further investigating role
Язык: Английский
Процитировано
4
Neuroscience Insights, Год журнала: 2024, Номер 19
Опубликована: Янв. 1, 2024
Obstetric brachial plexus palsy (OBPP) is a condition impairing limb function caused by birth injury. In 20 to 30% of cases, severe OBPP can cause life constraints in feeding, grooming, and clothing tasks.
Язык: Английский
Процитировано
1
Environmental Progress & Sustainable Energy, Год журнала: 2022, Номер 42(2)
Опубликована: Окт. 21, 2022
Abstract Worldwide consumption, toxicity, and bioaccumulation of paracetamol (PCM) atenolol (ATL) has drawn attention researchers over last decades. A small portion these drugs is absorbed by human body rest them excreted through urine feces to the environment (water bodies soil) which might result in negative impacts. Nanocomposite chromium oxide coupled with zinc hexacyanocobaltates (Cr 2 O 3 @ZnHCC) was synthesized a green‐method using Sapindus mukorossi seed‐extract for removal targeted drugs. Microscopic spectroscopic analysis Cr @ZnHCC showed uniformly incorporated prisms into cubic structure having ~75 nm particle size. Well‐characterized individuals & ZnHCC) were utilized degradation PCM ATL under direct sunlight dark conditions. Highest (91%–94%) resulted at 20 mg L −1 concentration pollutant, 25 catalyst dose, pH ~ 7 daylight exposure (5 h). First‐order kinetics followed high adsorption capacity, X m (13.4–14.5 g ) value obtained confirm strong binding pollutants. Moreover, substantially suppressed half‐life (PCM: 0.6 h; ATL: 2.9 h) converted safer‐small metabolites as confirmed liquid chromatography‐mass‐spectrometry analysis, reduction carbon content total organic analysis. The charge separation mechanism assisted UV reflectance photoluminescence data. green‐nano photocatalyst displayed reproducibility (up 10th cycle), sensitivity, stability during process makes this suitable candidate industrial applications.
Язык: Английский
Процитировано
6
WIREs Mechanisms of Disease, Год журнала: 2023, Номер 16(1)
Опубликована: Ноя. 3, 2023
Abstract Melanoma is one of the leading fatal forms cancer, yet from a treatment perspective, we have minimal control over its reoccurrence and resistance to current pharmacotherapies. The endocannabinoid system (ECS) has recently been accepted as multifaceted homeostatic regulator, influencing various physiological processes across different biological compartments, including skin. This review presents an overview pathophysiology melanoma, pharmacotherapy used for treatment, challenges associated with pharmacological approaches. Furthermore, it highlights utility cannabinoids additive remedy melanoma by restoring balance between downregulated immunomodulatory pathways elevated inflammatory cytokines during chronic skin conditions suggested critical approaches in treating this immunogenic tumor. article categorized under: Cancer > Molecular Cellular Physiology
Язык: Английский
Процитировано
2
Brain and Behavior, Год журнала: 2023, Номер 13(12)
Опубликована: Ноя. 6, 2023
Abstract Background Gaming behavior can induce cerebral changes that may be related to the neurobiological features of gaming disorder (GD). Additionally, individuals with higher levels depression or impulsivity are more likely experience GD. Therefore, present pilot study explored potential correlates GD in context and impulsivity, after accounting for video behavior. Methods Using resting‐state functional magnetic resonance imaging (fMRI), a cross‐sectional was conducted 35 highly involved male adult gamers examine associations between severity regional homogeneity (ReHo) entire brain. A mediation model used test role ReHo possible links depression/impulsivity severity. Results Individuals greater showed increased right Heschl's gyrus decreased hippocampus (rHip). Furthermore, were negatively correlated rHip, respectively. More importantly, rHip found mediate Conclusions These preliminary findings suggest is brain regions associated learning/memory/mood auditory function. Higher potentiate through activity hippocampus. Our advance our understanding differences behind symptoms gamers.
Язык: Английский
Процитировано
2
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2021, Номер unknown
Опубликована: Авг. 17, 2021
Abstract Neurogenesis is a complex process encompassing neuronal progenitor cell expansion/proliferation and differentiation, followed by neuron maturation. In vivo models are most commonly used to study neurogenesis; however, human induced pluripotent stem cell-derived (iPSC) neurons increasingly establish cellular of neurological processes. Unfortunately, the differentiation maturation iPSC-derived varies in methodology, asynchronous, has restricted experimental utility because extended differentiation/maturation times. To accelerate standardize iPS maturation, we differentiated matured feeder layer-free cultures under physiological oxygen levels (5%), modified underlying extracellular matrix medium composition. Our results demonstrate that calretinin gene expression occurred earlier our optimized conditions corresponding “neurogenesis burst” associated with proliferative expansion more synchronously, reliably emerging two three weeks after differentiation. As expected, mature markers ( i.e. , NeuN+/Calbindin+) started at 4-weeks post-differentiation. qPCR microarray, western blot single analyses using high content imaging indicated 4-week were non-cycling decreased cyclin D1 Ki67. data cues influence kinetics neurogenesis can be reproducibly miniaturized.
Язык: Английский
Процитировано
5
International review of neurobiology, Год журнала: 2023, Номер unknown, С. 267 - 305
Опубликована: Янв. 1, 2023
Язык: Английский
Процитировано
1
Toxicology Letters, Год журнала: 2023, Номер 391, С. 71 - 85
Опубликована: Дек. 14, 2023
Язык: Английский
Процитировано
1