Bioorganic Chemistry, Год журнала: 2025, Номер 160, С. 108441 - 108441
Опубликована: Апрель 5, 2025
Язык: Английский
Cancers, Год журнала: 2024, Номер 16(17), С. 2975 - 2975
Опубликована: Авг. 27, 2024
Malignant gliomas present great difficulties in treatment, with little change over the past 30 years median survival time of 15 months. Current treatment options include surgery, radiotherapy (RT), and chemotherapy. New therapies aimed at suppressing formation new vasculature (antiangiogenic treatments) or destroying formed tumor (vascular disrupting agents) show promise. This study summarizes existing knowledge regarding processes by which glioblastoma (GBM) tumors acquire resistance to antiangiogenic treatments. The discussion encompasses activation redundant proangiogenic pathways, heightened cell invasion metastasis, induced hypoxia, creation vascular mimicry channels, regulation immune microenvironment. Subsequently, we explore potential strategies overcome this resistance, such as combining other methods, personalizing treatments for each patient, focusing on therapeutic targets, incorporating immunotherapy, utilizing drug delivery systems based nanoparticles. Additionally, would like discuss limitations methods future directions enhance beneficial effects patients GBM. Therefore, review aims research outcome GBM provide a more promising opportunity thoroughly exploring mechanisms investigating novel strategies.
Язык: Английский
Процитировано
9
Nutrients, Год журнала: 2024, Номер 16(8), С. 1174 - 1174
Опубликована: Апрель 15, 2024
Alcoholic Fatty Liver Disease (AFLD) is characterized by the accumulation of lipids in liver cells owing to metabolism ethanol. This process leads a decrease NAD+/NADH ratio and generation reactive oxygen species. A systematic review meta-analysis were conducted investigate role oxidative stress AFLD. total 201 eligible manuscripts included, which revealed that animals with AFLD exhibited elevated expression CYP2E1, decreased enzymatic activity antioxidant enzymes, reduced levels transcription factor Nrf2, plays pivotal synthesis enzymes. Furthermore, increased lipid peroxidation markers carbonylated proteins, collectively contributing weakened defense damage. The damage was supported significantly higher alanine aspartate aminotransferase Moreover, had triacylglycerol serum liver, likely due fatty acid caused PPAR-α expression, responsible for oxidation, SREBP-1c, involved synthesis. With regard inflammation, pro-inflammatory cytokines, including TNF-a, IL-1β, IL-6. heightened stress, along led an upregulation cell death markers, such as caspase-3, Bax/Bcl-2 ratio. Overall, findings indicate ethanol reduces important while increasing inflammatory apoptotic thereby development
Язык: Английский
Процитировано
8
Frontiers in Marine Science, Год журнала: 2025, Номер 12
Опубликована: Фев. 5, 2025
This study evaluated the effects of hypoxia on heart juvenile four-finger threadfin ( Eleutheronema tetradactylum ) through physiological and transcriptome analysis. Juveniles with an average weight 122.82 g length 24.60 cm were used. Hypoxia significantly increased serum myocardial enzyme activities, including creatine kinase (CK), kinase-MB isoenzyme, lactate dehydrogenase (LDH), α-hydroxybutyrate (HDBH). These indicators initially rose then declined, reflecting cardiac stress suggesting their potential as early biomarkers for real-time aquaculture monitoring. Histological analysis revealed structural damage in fibers under hypoxia, increasing severity over time. underscores need to minimize oxygen fluctuations prevent tissue degeneration. Transcriptome identified upregulated genes involved cell communication, immune responses, intracellular signaling, offering targets breeding hypoxia-tolerant species. Kyoto Encyclopedia Genes Genomes pathway enrichment highlighted key pathways such mitogen-activated protein (MAPK), hypoxia-inducible factor-1 (HIF-1), endocytosis, phagosome formation. The MAPK plays a critical role cellular survival, proliferation, apoptosis. Hypoxia-induced activation MAPKs like ERK, JNK, p38 regulates stress-responsive genes. HIF-1 signaling homeostasis, HIF-1α stabilizing hypoxia-responsive VEGFA, which promotes vascular remodeling enhances delivery. findings collectively offer practical applications enhancing management, monitoring biochemical markers, adopting breeding, adjusting environmental conditions mitigate stress, ensuring better productivity sustainability. research provides foundation further studies molecular mechanisms
Язык: Английский
Процитировано
1
Cellular Signalling, Год журнала: 2024, Номер 122, С. 111329 - 111329
Опубликована: Авг. 5, 2024
Язык: Английский
Процитировано
7
Clinical and Experimental Medicine, Год журнала: 2024, Номер 24(1)
Опубликована: Окт. 3, 2024
Язык: Английский
Процитировано
7
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 180, С. 117429 - 117429
Опубликована: Сен. 17, 2024
Язык: Английский
Процитировано
6
Food Bioscience, Год журнала: 2025, Номер 64, С. 105924 - 105924
Опубликована: Янв. 16, 2025
Язык: Английский
Процитировано
0
Cell Communication and Signaling, Год журнала: 2025, Номер 23(1)
Опубликована: Янв. 16, 2025
The complex interaction between circadian rhythms and physiological functions is essential for maintaining human health. At the heart of this lies PERIOD proteins (PERs), pivotal to clock, influencing timing behavioral processes impacting oxidative stress, immune functionality, tumorigenesis. PER1 orchestrates cooperation enzyme GPX1, modulating mitochondrial dynamics in sync with daily thus regulating mechanisms managing energy substrates. PERs innate cells modulate temporal patterns NF-κB TNF-α activities, as well response LPS-induced toxic shock, initiating inflammatory responses that escalate into chronic conditions. Crucially, cancer cell behaviors including proliferation, apoptosis, migration by levels cycle stimulating expression oncogenes c-Myc MDM2. PER2/3, antagonists stem biology, play important roles differentiating their stemness. Importantly, Pers serve a significant factor early diagnosis prognosis. This review delves link rhythm regulator PERs, disruptions rhythm, oncogenesis. We examine evidence highlights how dysfunctions activities initiate development, aid tumor growth, modify metabolism through pathways involved stress system. Comprehending these connections opens new development rhythm-based therapeutic strategies, aims boosting enhancing treatments.
Язык: Английский
Процитировано
0
Aging and Disease, Год журнала: 2025, Номер unknown, С. 0 - 0
Опубликована: Янв. 1, 2025
Aging is marked by a progressive decrease in physiological function and reserve capacity, which results increased susceptibility to diseases. Understanding the mechanisms of driving aging crucial for extending health span promoting human longevity. Hypoxia, reduced oxygen availability, has emerged as promising area study within research. This review explores recent findings on potential restriction promote healthy extend lifespan. While role hypoxia-inducible factor 1 (HIF-1) cellular responses hypoxia well-established, its impact lifespan remains complex context-dependent. Investigations invertebrate models suggest HIF-1 longevity, while evidence mammalian limited. Hypoxia extends independent dietary (DR), known intervention underlying However, both DR converge common downstream effectors, such forkhead box O (FOXO) flavin-containing monooxygenase (FMOs) modulate Further work required elucidate molecular hypoxia-induced longevity optimize clinical applications. crosstalk between other longevity-associated pathways developing interventions enhance healthspan. Future studies may uncover novel therapeutic strategies populations.
Язык: Английский
Процитировано
0
Ukrainian Journal of Nephrology and Dialysis, Год журнала: 2025, Номер 1(85), С. 23 - 28
Опубликована: Фев. 24, 2025
Nephrotic syndrome (NS) is a kidney disorder caused by increased permeability of the glomerular filtration barrier. The diagnosis based on four main clinical features: edema, hyperlipidemia, hypoalbuminemia, and proteinuria. pathogenesis NS linked to multiple pathways, including inflammation apoptosis. present study aimed assess oxidative stress hypoxia parameters in children with NS. Methods. This cross-sectional included 88 patients at different stages chronic disease (CKD) 25 healthy individuals (control group). Plasma samples were used measure intracellular hypoxia-inducible factor alpha (HIF-1α) manganese superoxide dismutase (Mn-SOD). levels radicals assessed using electron paramagnetic resonance (EPR) method. ANOVA, followed post hoc Kruskal-Wallis test for comparisons, was determine statistical significance. Statistical analysis performed Past4 software Windows. A p-value <0.05 considered statistically significant. Results. significant increase generation rate radical anions (O₂⁻•) neutrophils detected all (1.55±0.7 nmol/1×10³ cells/min CKD I stage group 2.79±0.22 II–III group, p<0.01). expression Mn-SOD reduced 76.57±4.62% further decreased 59.03±3.23% compared control (p<0.01 p<0.001, respectively). Individual plasma HIF-1α revealed inverse correlation between these biomarkers (r=-0.71, p<0.0001, CI: -0.8003 -0.5878). Conclusions. demonstrates that activation leads reduction antioxidative capacity nephrotic syndrome. An observed levels, suggesting potential interplay pathogenesis.
Язык: Английский
Процитировано
0