An active inference account of stuttering behavior DOI Creative Commons
Evan Usler

Frontiers in Human Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Апрель 3, 2025

This paper presents an interpretation of stuttering behavior, based on the principles active inference framework. Stuttering is a neurodevelopmental disorder characterized by speech disfluencies such as repetitions, prolongations, and blocks. The inference, theory predictive processing sentient can be used to conceptualize disruption in perception-action cycling underlying production. proposed here posits that arises from aberrant sensory precision prediction error dynamics, inhibiting syllable initiation. Relevant this theory, two hypothesized mechanisms are proposed: (1) mistiming (2) excessive attentional focus. Both highlight role neural oscillations, error, hierarchical integration framework also explains contextual variability behaviors, including adaptation effects fluency-inducing conditions. Reframing synaptopathy integrates neurobiological, psychological, behavioral dimensions, suggesting disruptions precision-weighting mediated neuromodulatory systems. perspective provides unified account sets stage for innovative research therapeutic approaches.

Язык: Английский

Conceptual foundations of physiological regulation incorporating the free energy principle and self-organized criticality DOI Creative Commons

Jesse S. Bettinger,

Karl Friston

Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 155, С. 105459 - 105459

Опубликована: Ноя. 11, 2023

Bettinger, J. S., K. Friston. Conceptual Foundations of Physiological Regulation incorporating the Free Energy Principle & Self-Organized Criticality. NEUROSCI BIOBEHAV REV 23(x) 144-XXX, 2022. Since late nineteen-nineties, concept homeostasis has been contextualized within a broader class "allostatic" dynamics characterized by wider-berth causal factors including social, psychological and environmental entailments; fundamental nature integrated brain-body dynamics; plus role anticipatory, top-down constraints supplied intrinsic regulatory models. Many these evidentiary are integral in original descriptions homeostasis; subsequently integrated; and/or cite more-general operating principles self-organization. As result, allostasis may be generalized to larger category variational systems biology, engineering physics terms advances complex systems, statistical mechanics involving heterogenous (hierarchical/heterarchical, modular) like brain-networks internal milieu. This paper offers three-part treatment. 1) interpret "allostasis" emphasize relational foundation physiological stability; 2) adapt as "stability through change" include "return stability" 3) reframe model with conceptual criticality that licenses upgrade dynamics.

Язык: Английский

Процитировано

14
Mapping expectancy-based appetitive placebo effects onto the brain in women DOI Creative Commons
Iraj Khalid, Belina Rodrigues,

Hippolyte Dreyfus

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Янв. 4, 2024

Abstract Suggestions about hunger can generate placebo effects on experiences. But, the underlying neurocognitive mechanisms are unknown. Here, we show in 255 women that expectancies, induced by suggestion-based interventions, determine sensations and economic food choices. Functional magnetic resonance imaging a subgroup ( n = 57/255) provides evidence strength of expecting to decrease moderates medial prefrontal cortex activation at time choice attenuates ventromedial (vmPFC) responses value. Dorsolateral linked interference resolution formally mediates hunger. A drift-diffusion model characterizes this effect showing suggestions bias participants’ choices how much they weigh tastiness against healthiness food, which further vmPFC–dlPFC psychophysiological interactions when participants expect decreased Thus, suggestion-induced beliefs shape addressing through cognitive regulation value computation within cortex.

Язык: Английский

Процитировано

6
Acetylcholine modulates the precision of prediction error in the auditory cortex DOI Creative Commons
David Pérez-González, Ana B. Lao-Rodríguez, Cristián Aedo

и другие.

eLife, Год журнала: 2024, Номер 12

Опубликована: Янв. 19, 2024

A fundamental property of sensory systems is their ability to detect novel stimuli in the ambient environment. The auditory brain contains neurons that decrease response repetitive sounds but increase firing rate or deviant stimuli; difference between both responses known as stimulus-specific adaptation neuronal mismatch (nMM). Here, we tested effect microiontophoretic applications ACh on cortex (AC) anesthetized rats during an oddball paradigm, including cascade controls. Results indicate modulates nMM, affecting prediction error not repetition suppression, and this manifested predominantly infragranular cortical layers. differential standards, relative deviants (in terms averages variances), was consistent with representational sharpening accompanies precision errors. These findings suggest plays important role modulating signaling AC gating access these signals higher cognitive levels.

Язык: Английский

Процитировано

6
Aberrant heartbeat-evoked potential in schizophrenia DOI Creative Commons
Akihiro Koreki, Kamiyu Ogyu, Takahiro Miyazaki

и другие.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2024, Номер 132, С. 110969 - 110969

Опубликована: Фев. 16, 2024

Язык: Английский

Процитировано

5
Psilocybin increases optimistic engagement over time: computational modelling of behaviour in rats DOI Creative Commons
Elizabeth L. Fisher, Ryan Smith, Kyna‐Anne Conn

и другие.

Translational Psychiatry, Год журнала: 2024, Номер 14(1)

Опубликована: Сен. 30, 2024

Язык: Английский

Процитировано

5
Formalizing psychological interventions through network control theory DOI Creative Commons
Julia Elina Stocker, Georgia Koppe, Hanna Reich

и другие.

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Авг. 24, 2023

Despite the growing deployment of network representation to comprehend psychological phenomena, question whether and how networks can effectively describe effects interventions remains elusive. Network control theory, engineering study networked interventions, has recently emerged as a viable methodology characterize guide interventions. However, there is scarcity empirical studies testing extent which it be useful within context. In this paper, we investigate representative intervention experiment, use theory model predict its effect. Using data, showed that: (1) observed effect, in terms sensitivity specificity, relates regional theoretic metrics (average modal controllability), (2) size change following negatively correlates with whole-network topology that quantifies "ease" described by (control energy), (3) responses after predicted based on formal results from theory. These insights assert significant potential tool for investigating Drawing specific example overarching framework further elaborate conceptualization methodological considerations, future directions burgeoning field.

Язык: Английский

Процитировано

10
Neurochemical markers of uncertainty processing in humans DOI Creative Commons
Nazia Jassim, Peter Thestrup Waade, Owen Parsons

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Фев. 19, 2025

Abstract How individuals process and respond to uncertainty has important implications for cognition mental health. Here we use computational phenotyping examine individualised “uncertainty fingerprints” in relation neurometabolites trait anxiety humans. We introduce a novel categorical state-transition extension of the Hierarchical Gaussian Filter (HGF) capture implicit learning four-choice probabilistic sensorimotor reversal task by tracking beliefs about stimulus transitions. Using 7-Tesla Magnetic Resonance Spectroscopy, measured baseline neurotransmitter levels primary motor cortex (M1). Model-based results revealed dynamic belief updating response environmental changes. further found region-specific relationships between M1 glutamate+ glutamine prediction errors volatility beliefs, revealing an neural marker High was associated with faster post-reversal responses. By integrating modelling neurochemical assessments, this study provides insights into neurocomputations that drive individual differences processing uncertainty.

Язык: Английский

Процитировано

0
How preferences enslave attention: calling into question the endogenous/exogenous dichotomy from an active inference perspective DOI Creative Commons
Darius Parvizi-Wayne

Phenomenology and the Cognitive Sciences, Год журнала: 2024, Номер unknown

Опубликована: Сен. 18, 2024

Язык: Английский

Процитировано

3
Frequency-specific changes in prefrontal activity associated with maladaptive belief updating in volatile environments in euthymic bipolar disorder DOI Creative Commons
Marina Ivanova, Ksenia Germanova, D. S. Petelin

и другие.

Translational Psychiatry, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 17, 2025

Язык: Английский

Процитировано

0
As One and Many: Relating Individual and Emergent Group-Level Generative Models in Active Inference DOI Creative Commons
Peter Thestrup Waade, C. Olesen, Jonathan Ehrenreich Laursen

и другие.

Entropy, Год журнала: 2025, Номер 27(2), С. 143 - 143

Опубликована: Фев. 1, 2025

Active inference under the Free Energy Principle has been proposed as an across-scales compatible framework for understanding and modelling behaviour self-maintenance. Crucially, a collective of active agents can, if they maintain group-level Markov blanket, constitute larger agent with generative model its own. This potential computational scale-free structures speaks to application self-organizing systems across spatiotemporal scales, from cells human collectives. Due difficulty reconstructing that explains emergent agents, there little research on this kind multi-scale inference. Here, we propose data-driven methodology characterising relation between dynamics constituent individual agents. We apply methods cognitive psychiatry, applicable well other types approaches. Using simple Multi-Armed Bandit task example, employ new ActiveInference.jl library Julia simulate who are equipped blanket. use sampling-based parameter estimation make inferences about agent, show is non-trivial relationship models constitute, even in setting. Finally, point number ways which might be applied better understand relations nested scales.

Язык: Английский

Процитировано

0