Mapping expectancy-based appetitive placebo effects onto the brain in women

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 4, 2024

Abstract Suggestions about hunger can generate placebo effects on experiences. But, the underlying neurocognitive mechanisms are unknown. Here, we show in 255 women that expectancies, induced by suggestion-based interventions, determine sensations and economic food choices. Functional magnetic resonance imaging a subgroup ( n = 57/255) provides evidence strength of expecting to decrease moderates medial prefrontal cortex activation at time choice attenuates ventromedial (vmPFC) responses value. Dorsolateral linked interference resolution formally mediates hunger. A drift-diffusion model characterizes this effect showing suggestions bias participants’ choices how much they weigh tastiness against healthiness food, which further vmPFC–dlPFC psychophysiological interactions when participants expect decreased Thus, suggestion-induced beliefs shape addressing through cognitive regulation value computation within cortex.

Language: Английский

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Acetylcholine modulates the precision of prediction error in the auditory cortex

eLife, Journal Year: 2024, Volume and Issue: 12

Published: Jan. 19, 2024

A fundamental property of sensory systems is their ability to detect novel stimuli in the ambient environment. The auditory brain contains neurons that decrease response repetitive sounds but increase firing rate or deviant stimuli; difference between both responses known as stimulus-specific adaptation neuronal mismatch (nMM). Here, we tested effect microiontophoretic applications ACh on cortex (AC) anesthetized rats during an oddball paradigm, including cascade controls. Results indicate modulates nMM, affecting prediction error not repetition suppression, and this manifested predominantly infragranular cortical layers. differential standards, relative deviants (in terms averages variances), was consistent with representational sharpening accompanies precision errors. These findings suggest plays important role modulating signaling AC gating access these signals higher cognitive levels.

Language: Английский

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Conceptual foundations of physiological regulation incorporating the free energy principle and self-organized criticality

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 155, P. 105459 - 105459

Published: Nov. 11, 2023

Bettinger, J. S., K. Friston. Conceptual Foundations of Physiological Regulation incorporating the Free Energy Principle & Self-Organized Criticality. NEUROSCI BIOBEHAV REV 23(x) 144-XXX, 2022. Since late nineteen-nineties, concept homeostasis has been contextualized within a broader class "allostatic" dynamics characterized by wider-berth causal factors including social, psychological and environmental entailments; fundamental nature integrated brain-body dynamics; plus role anticipatory, top-down constraints supplied intrinsic regulatory models. Many these evidentiary are integral in original descriptions homeostasis; subsequently integrated; and/or cite more-general operating principles self-organization. As result, allostasis may be generalized to larger category variational systems biology, engineering physics terms advances complex systems, statistical mechanics involving heterogenous (hierarchical/heterarchical, modular) like brain-networks internal milieu. This paper offers three-part treatment. 1) interpret "allostasis" emphasize relational foundation physiological stability; 2) adapt as "stability through change" include "return stability" 3) reframe model with conceptual criticality that licenses upgrade dynamics.

Language: Английский

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Aberrant heartbeat-evoked potential in schizophrenia

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2024, Volume and Issue: 132, P. 110969 - 110969

Published: Feb. 16, 2024

Language: Английский

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Frequency-specific changes in prefrontal activity associated with maladaptive belief updating in volatile environments in euthymic bipolar disorder

Translational Psychiatry, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 17, 2025

Language: Английский

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As One and Many: Relating Individual and Emergent Group-Level Generative Models in Active Inference

Entropy, Journal Year: 2025, Volume and Issue: 27(2), P. 143 - 143

Published: Feb. 1, 2025

Active inference under the Free Energy Principle has been proposed as an across-scales compatible framework for understanding and modelling behaviour self-maintenance. Crucially, a collective of active agents can, if they maintain group-level Markov blanket, constitute larger agent with generative model its own. This potential computational scale-free structures speaks to application self-organizing systems across spatiotemporal scales, from cells human collectives. Due difficulty reconstructing that explains emergent agents, there little research on this kind multi-scale inference. Here, we propose data-driven methodology characterising relation between dynamics constituent individual agents. We apply methods cognitive psychiatry, applicable well other types approaches. Using simple Multi-Armed Bandit task example, employ new ActiveInference.jl library Julia simulate who are equipped blanket. use sampling-based parameter estimation make inferences about agent, show is non-trivial relationship models constitute, even in setting. Finally, point number ways which might be applied better understand relations nested scales.

Language: Английский

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Frustration in physiology and molecular medicine

Molecular Aspects of Medicine, Journal Year: 2025, Volume and Issue: 103, P. 101362 - 101362

Published: April 23, 2025

Molecules provide the ultimate language in terms of which physiology and pathology must be understood. Myriads proteins participate elaborate networks interactions perform chemical activities coordinating life cells. To these often amazing tasks, move we think them as dynamic ensembles three dimensional structures formed first by folding polypeptide chains so to minimize conflicts between their constituent amino acids. It is apparent however that, even when completely folded, not all conflicting have been resolved structure remains "locally frustrated". Over last decades it has become clearer that this local frustration just a random accident but plays an essential part inner workings protein molecules. We will review here physical origins concept evidence important for physiology, protein-protein recognition, catalysis allostery. Also, highlight examples showing how alterations patterns can linked distinct pathologies. Finally explore extensions impact higher order levels organization systems including gene regulatory neural brain.

Language: Английский

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Neurochemical markers of uncertainty processing in humans

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Abstract How individuals process and respond to uncertainty has important implications for cognition mental health. Here we use computational phenotyping examine individualised “uncertainty fingerprints” in relation neurometabolites trait anxiety humans. We introduce a novel categorical state-transition extension of the Hierarchical Gaussian Filter (HGF) capture implicit learning four-choice probabilistic sensorimotor reversal task by tracking beliefs about stimulus transitions. Using 7-Tesla Magnetic Resonance Spectroscopy, measured baseline neurotransmitter levels primary motor cortex (M1). Model-based results revealed dynamic belief updating response environmental changes. further found region-specific relationships between M1 glutamate+ glutamine prediction errors volatility beliefs, revealing an neural marker High was associated with faster post-reversal responses. By integrating modelling neurochemical assessments, this study provides insights into neurocomputations that drive individual differences processing uncertainty.

Language: Английский

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Human regulatory systems in the age of abundance: A predictive processing perspective

Annals of the New York Academy of Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Abstract Human regulatory systems largely evolved under conditions of food and information scarcity but are now being forced to deal with abundance. The impact abundance the inability human adapt it have fed a surge in dual health challenges: (1) rise obesity related (2) stress anxiety No single framework has been developed describe why how transition from so challenging. Here, we provide speculative model based on predictive processing. We suggest that whereas (above destructive lower bounds like famine or voids) preserves fidelity relationship between prediction errors predictions, distorts this relationship. Furthermore, error minimization is enhanced (as number competing states niche restricted), opposite true also discuss warps fundamental drive for seeking novelty by fueling brain's exploration opposed exploitation) mode. Ameliorative strategies regulating may depend simulating scarcity, environmental condition which adapted over millennia.

Language: Английский

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Bird’s Eye View of Artificial Intelligence in Neuroscience

AI in neuroscience., Journal Year: 2025, Volume and Issue: 1(1), P. 16 - 41

Published: March 1, 2025

Language: Английский

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