Trends in Ecology & Evolution, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Physiological Reviews, Год журнала: 2024, Номер 104(3), С. 1205 - 1263
Опубликована: Март 14, 2024
Stress resilience is the phenomenon that some people maintain their mental health despite exposure to adversity or show only temporary impairments followed by quick recovery. Resilience research attempts unravel factors and mechanisms make possible harness its insights for development of preventative interventions in individuals at risk acquiring stress-related dysfunctions. Biological has been lagging behind psychological social sciences but seen a massive surge recent years. At same time, progress this field hampered methodological challenges related finding suitable operationalizations study designs, replicating findings, modeling animals. We embed review behavioral, neuroimaging, neurobiological, systems biological findings adults critical methods discussion. find preliminary evidence hippocampus-based pattern separation prefrontal-based cognitive control functions protect against pathological fears aftermath singular, event-type stressors [as found fear-related disorders, including simpler forms posttraumatic stress disorder (PTSD)] facilitating perception safety. Reward system-based pursuit savoring positive reinforcers appear more generalized dysfunctions anxious-depressive spectrum resulting from severe longer-lasting (as depression, comorbid anxiety, PTSD). Links between preserved functioning these neural under neuroplasticity, immunoregulation, gut microbiome composition, integrity barrier blood-brain are beginning emerge. On basis, avenues pointed out.
Язык: Английский
Процитировано
26
Frontiers in Neuroendocrinology, Год журнала: 2024, Номер 72, С. 101118 - 101118
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
21
Biochemistry (Moscow), Год журнала: 2023, Номер 88(5), С. 565 - 589
Опубликована: Май 1, 2023
The review analyzes modern concepts about the control of various mechanisms hippocampal neuroplasticity in adult mammals and humans by glucocorticoids. Glucocorticoid hormones ensure coordinated functioning key components plasticity: neurogenesis, glutamatergic neurotransmission, microglia astrocytes, systems neurotrophic factors, neuroinflammation, proteases, metabolic hormones, neurosteroids. Regulatory are diverse; along with direct action glucocorticoids through their receptors, there conciliated glucocorticoid-dependent effects, as well numerous interactions between components. Despite fact that many connections this complex regulatory scheme have not yet been established, study factors considered work forms growth points field glucocorticoid-regulated processes brain primarily hippocampus. These studies fundamentally important for translation into clinic potential treatment/prevention common diseases emotional cognitive spheres respective comorbid conditions.
Язык: Английский
Процитировано
35
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2025, Номер 137, С. 111280 - 111280
Опубликована: Фев. 3, 2025
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12155 - 12155
Опубликована: Ноя. 12, 2024
The interplay between functional food nutrients and neurosteroids has garnered significant attention for its potential to enhance stress resilience in health and/or disease. Several bioactive nutrients, including medicinal herbs, flavonoids, bioavailable polyphenol-combined nanoparticles, as well probiotics, vitamin D omega-3 fatty acids, have been shown improve blood-brain barrier (BBB) dysfunction, endogenous neurosteroid homeostasis brain function. These can inhibit oxidative neuroinflammation, which are linked the pathogenesis of various neurological disorders. Interestingly, flavonoids exhibit dose-dependent effects, activating nuclear factor erythroid 2-related 2 (Nrf2) pathway at physiological/low dose (neurohormesis). This leads upregulation antioxidant phase II genes proteins such heme oxygenase-1 (HO-1) sirtuin-1 (Sirt1), activated by curcumin resveratrol, respectively. adaptive neuronal response mechanisms help protect against reactive oxygen species (ROS) neurotoxicity. Impaired Nrf2 hormone signaling exacerbate selective vulnerability neuroinflammatory conditions, contributing onset progression neurodegenerative psychiatric disorders, Alzheimer's disease, anxiety depression other due neurons stress. review focuses on targeting redox regulate BBB damage associated with altered GABAergic neurotransmission. By exploring underlying molecular using innovative technologies, we aim develop promising neuroprotective strategies personalized nutritional neuroregenerative therapies prevent or attenuate ultimately promoting health.
Язык: Английский
Процитировано
8
Neurobiology of Stress, Год журнала: 2024, Номер 33, С. 100670 - 100670
Опубликована: Сен. 3, 2024
Exposure to chronic stress contributes considerably the development of cognitive impairments in psychiatric disorders such as depression, generalized anxiety disorder (GAD), obsessive-compulsive (OCD), post-traumatic (PTSD), and addictive behavior. Unfortunately, unlike mood-related symptoms, are not effectively treated by available therapies, a situation part resulting from still incomplete knowledge neurobiological substrates that underly domains difficulty generating interventions both efficacious safe. In this review, we will present an overview affected with specific focus on flexibility, behavioral inhibition, working memory. We then consider effects neuronal correlates function factors which may modulate interaction cognition. Finally, discuss intervention strategies for treatment stress-related gaps emerging new treatments under development. Understanding how impairment occurs during exposure is crucial make progress towards effective therapeutic approaches.
Язык: Английский
Процитировано
7
Journal of Affective Disorders, Год журнала: 2023, Номер 331, С. 369 - 379
Опубликована: Март 25, 2023
Язык: Английский
Процитировано
12
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Апрель 2, 2024
Background: Depression is a severe mental disorder that poses significant threat to both the physical and wellbeing of individuals. Currently, there are various methods for treating depression, including traditional Chinese herbal formulations like Chaihu-Shugan-San (CSS), which have shown effective antidepressant effects in clinical animal research. Objective: This review aims provide comprehensive synthesis evidence related CSS, considering preclinical studies, uncover its potential multi-level, multi-pathway, multi-target mechanisms depression identify active ingredients. Methods: A thorough search was conducted electronic databases, PubMed, MEDLINE, Web Science, Google Scholar, CNKI, Wanfang, using keywords such as “Chaihu Shugan” “depression” retrieve relevant literature on CSS The process adhered PRISMA guidelines. Results: consolidates underlying It emphasizes involvement regulation monoaminergic neurotransmitter systems, synaptic plasticity, hypothalamic-pituitary-adrenal axis, among other aspects. Conclusion: exerts pivotal role through pathways, system, inflammation, brain-derived neurotrophic factor levels, brain-gut axis. facilitates understanding current state research, fostering an in-depth exploration etiological discovery novel drugs.
Язык: Английский
Процитировано
4
Frontiers in Neuroendocrinology, Год журнала: 2024, Номер 74, С. 101146 - 101146
Опубликована: Июль 1, 2024
Over the past two decades, there has been increasing evidence for importance of rapid-onset actions corticosteroid hormones in brain. Here, we highlight distinct rapid that regulate excitatory and inhibitory synaptic transmission hypothalamus, hippocampus, basolateral amygdala, prefrontal cortex. The receptors mediate are located at or close to plasma membrane, though many receptor characteristics remain unresolved. Rapid-onset effects play a role fast neuroendocrine feedback as well higher brain functions, including increased aggression anxiety, impaired memory retrieval. non-genomic precede complement slow-onset, long-lasting transcriptional steroids. Both slow appear be indispensable adapt continuously changing environment, their imbalance can increase an individual's susceptibility psychopathology.
Язык: Английский
Процитировано
4
BMC Psychiatry, Год журнала: 2025, Номер 25(1)
Опубликована: Янв. 7, 2025
Abstract Background Childhood adversities and traumata (CAT) increase the risk for various mental disorders, including clinical high-risk of psychosis (CHR-P) state its main comorbidities, i.e., depression, social phobia. However, these relations are likely mediated by personal coping behaviors. This cross-sectional study investigates relationships between CAT domains, coping, CHR-P, Methods Using path analyses, we analyzed data 736 patients (mean age 24 years, 67% male) who presented at an early detection service 2002 2013, answered questionnaires on CAT, depressiveness, phobia, underwent examination CHR-P according to recommendations Guidance project European Psychiatric Association. Results All models (total sample, males females) showed good excellent fit data. In all models, higher scores maladaptive negative effect emotional abuse health outcomes. Additionally, in total sample males, lower adaptive neglect, physical neglect was associated with that, turn, were linked depression phobia but not CHR-P. Overall, effects than those although more diversely CAT. Furthermore, interrelated widely explained which significantly them. Conclusions Our findings underscore complex interplay domains their relevant mediators outcomes that reflect underlying sex-specific psychological, social, cultural neurobiological mechanisms. Supporting a broader view traditional focus sexual abuse, results indicate important role descriptively, is most strongly strategies A detailed understanding will future help develop multi-dimensional, holistic approach treatment have experienced Trial registration The registered German Clinical Register ( https://drks.de/ ) as DRKS00024469 02/24/2021.
Язык: Английский
Процитировано
0