Mucosal Immunology,
Год журнала:
2023,
Номер
16(2), С. 221 - 231
Опубликована: Янв. 25, 2023
The
intestinal
barrier
is
a
complex
structure
that
allows
the
absorption
of
nutrients
while
ensuring
protection
against
pathogens
and
balanced
immunity.
development
maintenance
functional
multifactorial
process
only
partially
understood.
Here
we
review
novel
findings
on
emerging
role
mesenchymal
cells
in
this
using
insights
gained
from
lineage
tracing
approaches,
Cre-based
gene
deletion,
single-cell
transcriptomics.
current
evidence
points
toward
key
organizer
for
distinct
lineages
homeostasis,
regulating
both
epithelial
immune
components
barrier.
We
further
discuss
recent
heterogeneity
implications
regeneration
inflammatory
pathologies.
Science,
Год журнала:
2021,
Номер
374(6571), С. 1087 - 1092
Опубликована: Ноя. 25, 2021
The
brain
and
gastrointestinal
tract
are
critical
sensory
organs
responsible
for
detecting,
relaying,
integrating,
responding
to
signals
derived
from
the
internal
external
environment.
At
interface
of
this
function,
immune
cells
in
intestines
consistently
survey
environmental
factors,
eliciting
responses
that
inform
on
physiological
state
body.
Recent
research
reveals
cross-talk
along
gut-brain
axis
regulates
inflammatory
nociception,
responses,
homeostasis.
Here,
we
discuss
molecular
cellular
mechanisms
involved
signaling
inflammation
across
axis.
We
further
highlight
interactions
between
gut
inflammation-associated
diseases.
Physiological Reviews,
Год журнала:
2022,
Номер
103(2), С. 1487 - 1564
Опубликована: Дек. 15, 2022
Of
all
the
organ
systems
in
body,
gastrointestinal
tract
is
most
complicated
terms
of
numbers
structures
involved,
each
with
different
functions,
and
types
signaling
molecules
utilized.
The
digestion
food
absorption
nutrients,
electrolytes,
water
occurs
a
hostile
luminal
environment
that
contains
large
diverse
microbiota.
At
core
regulatory
control
digestive
defensive
functions
enteric
nervous
system
(ENS),
complex
neurons
glia
gut
wall.
In
this
review,
we
discuss
1)
intrinsic
neural
involved
2)
how
ENS
interacts
immune
system,
microbiota,
epithelium
to
maintain
mucosal
defense
barrier
function.
We
highlight
developments
have
revolutionized
our
understanding
physiology
pathophysiology
control.
These
include
new
molecular
architecture
ENS,
organization
function
motor
circuits,
roles
glia.
explore
transduction
stimuli
by
enteroendocrine
cells,
regulation
intestinal
glia,
local
role
microbiota
regulating
structure
ENS.
Multifunctional
work
together
glial
macrophages,
interstitial
cells
integrating
an
array
signals
initiate
outputs
are
precisely
regulated
space
time
homeostasis.
Nature Neuroscience,
Год журнала:
2023,
Номер
26(7), С. 1208 - 1217
Опубликована: Июнь 26, 2023
Autism
spectrum
disorder
(ASD)
is
a
neurodevelopmental
characterized
by
heterogeneous
cognitive,
behavioral
and
communication
impairments.
Disruption
of
the
gut-brain
axis
(GBA)
has
been
implicated
in
ASD
although
with
limited
reproducibility
across
studies.
In
this
study,
we
developed
Bayesian
differential
ranking
algorithm
to
identify
ASD-associated
molecular
taxa
profiles
10
cross-sectional
microbiome
datasets
15
other
datasets,
including
dietary
patterns,
metabolomics,
cytokine
human
brain
gene
expression
profiles.
We
found
functional
architecture
along
GBA
that
correlates
heterogeneity
phenotypes,
it
amino
acid,
carbohydrate
lipid
predominantly
encoded
microbial
species
genera
Prevotella,
Bifidobacterium,
Desulfovibrio
Bacteroides
changes,
restrictive
patterns
pro-inflammatory
The
revealed
age-matched
sex-matched
cohorts
not
present
sibling-matched
cohorts.
also
show
strong
association
between
temporal
changes
composition
phenotypes.
summary,
propose
framework
leverage
multi-omic
from
well-defined
investigate
how
influences
ASD.
World Journal of Gastroenterology,
Год журнала:
2023,
Номер
29(28), С. 4368 - 4383
Опубликована: Июль 26, 2023
The
human
intestine
is
a
natural
environment
ecosystem
of
complex
diversified
and
dynamic
microorganisms,
determined
through
process
competition
selection
during
life.
Those
intestinal
microorganisms
called
microbiota
are
involved
in
variety
mechanisms
the
organism,
they
interact
with
host
therefore
contact
organs
various
systems.
However,
play
crucial
role
maintaining
homeostasis,
also
influencing
its
behaviour.
Thus,
perform
series
biological
functions
important
for
well-being.
provides
nutrients,
simultaneously
drawing
many
benefits
such
as
their
contribution
to
metabolic,
trophic,
immunological,
other
functions.
For
these
reasons
it
has
been
reported
that
quantitative
qualitative
composition
can
protective
or
harmful
on
health.
Therefore,
dysbiosis
lead
an
association
unfavourable
factors
which
dysregulation
physiological
processes
homeostasis.
pre-viously
noted
gut
participate
pathogenesis
autoimmune
diseases,
chronic
inflammation,
diabetes
mellitus,
obesity
atherosclerosis,
neurological
disorders
(e.g.,
autism,
etc.)
colorectal
cancer,
more.
Cell,
Год журнала:
2023,
Номер
186(16), С. 3386 - 3399.e15
Опубликована: Авг. 1, 2023
The
gastrointestinal
tract
is
in
a
state
of
constant
motion.
These
movements
are
tightly
regulated
by
the
presence
food
and
help
digestion
mechanically
breaking
down
propelling
gut
content.
Mechanical
sensing
thought
to
be
essential
for
regulating
motility;
however,
identity
neuronal
populations,
molecules
involved,
functional
consequences
this
sensation
unknown.
Here,
we
show
that
humans
lacking
PIEZO2
exhibit
impaired
bowel
motility.
Piezo2
mouse
dorsal
root,
but
not
nodose
ganglia
required
sense
content,
activity
slows
transit
rates
stomach,
small
intestine,
colon.
Indeed,
directly
detect
colon
distension
vivo.
Our
study
unveils
mechanosensory
mechanisms
regulate
luminal
contents
throughout
gut,
which
critical
process
ensure
proper
digestion,
nutrient
absorption,
waste
removal.
Neuroimmune
cross-talk
participates
in
intestinal
tissue
homeostasis
and
host
defense.
However,
the
matrix
of
interactions
between
arrays
molecularly
defined
neuron
subsets
immunocyte
lineages
remains
unclear.
We
used
a
chemogenetic
approach
to
activate
eight
distinct
neuronal
subsets,
assessing
effects
by
deep
immunophenotyping,
microbiome
profiling,
transcriptomics
organs.
Distinct
immune
perturbations
followed
activation:
Nitrergic
neurons
regulated
T
helper
17
(T
Annual Review of Immunology,
Год журнала:
2024,
Номер
42(1), С. 489 - 519
Опубликована: Июнь 28, 2024
Recent
advances
have
contributed
to
a
mechanistic
understanding
of
neuroimmune
interactions
in
the
intestine
and
revealed
an
essential
role
this
cross
talk
for
gut
homeostasis
modulation
inflammatory
infectious
intestinal
diseases.
In
review,
we
describe
innervation
by
intrinsic
extrinsic
neurons
then
focus
on
bidirectional
communication
between
immune
cells.
First,
highlight
contribution
neuronal
subtypes
development
colitis
discuss
different
epithelial
cell
types
that
are
regulated
via
release
neuropeptides
neurotransmitters.
Next,
review
inflammation
visceral
hypersensitivity
summarize
how
mediators
induce
peripheral
central
sensitization
gut-innervating
sensory
neurons.
Finally,
outline
importance
cells
microbiota
survival
function
populations
at
during
bacterial
helminth
infection.
