Poultry Science,
Год журнала:
2023,
Номер
102(12), С. 103162 - 103162
Опубликована: Окт. 2, 2023
The
aim
of
this
study
was
to
examine
effects
various
daylight
exposure
during
the
24-h
light-dark
(L-D)
cycle
on
growth
performance,
skeletal
health,
and
welfare
state
in
broilers.
Environmental
photoperiod
related
circadian
clock,
L-D
cycle,
are
important
factors
maintaining
productive
pathophysiological
homeostasis,
psychological
reaction
humans
animals.
Currently,
lighting
programs
as
management
tools
for
providing
a
satisfactory
environmental
condition
have
been
used
commercial
broiler
production.
Four
hundred
thirty-two
1-d-old
Rose
308
chicks
were
assigned
24
pens
(18
birds/pen).
randomly
1
4
thermal
control
rooms,
then
birds
exposed
(n=6):
1)
12L,
2)
16L,
3)
18L,
or
4)
20L
at
15
d
age.
Lighting
program
bird
body
weight,
behavioral
patterns,
bone
stress
levels
evaluated
from
35
45,
respectively.
12L
well
16L
groups,
reared
under
short
photoperiods
close
natural
had
improved
production
leg
suppressed
compared
both
18L
groups.
Especially,
heavier
final
weight
averaged
daily
gain
(P
<
0.05),
higher
BMD
BMC
with
longer
wider
femur
lower
H/L
ratio
more
reached
observer
touch
test
0.05)
but
spent
shorter
latency
tonic
immobility
0.05).
Taken
together,
data
suggest
that
supplying
12
h
light
improves
performance
health
while
decreasing
broilers,
making
it
potentially
suitable
approach
The Journal of Physiology,
Год журнала:
2023,
Номер
601(20), С. 4491 - 4538
Опубликована: Сен. 27, 2023
The
physiological
consequences
of
stress
often
manifest
in
the
gastrointestinal
tract.
Traumatic
or
chronic
is
associated
with
widespread
maladaptive
changes
throughout
gut,
although
comparatively
little
known
about
effects
acute
stress.
Furthermore,
these
stress-induced
gut
may
increase
susceptibility
to
disorders
and
infection,
impact
critical
features
neural
behavioural
response
by
impairing
gut-brain
axis
communication.
Understanding
mechanisms
behind
enteric
nervous
system
circuitry,
visceral
sensitivity,
barrier
function,
permeability,
microbiota
following
an
important
research
objective
pathophysiological
implications
both
neurogastroenterology
psychiatry.
Moreover,
has
emerged
as
a
key
aspect
physiology
sensitive
In
this
review,
we
focus
on
different
aspects
tract
including
function
well
immune,
humoral
neuronal
elements
involved
discuss
evidence
for
role
disorders.
Existing
gaps
current
literature
are
highlighted,
possible
avenues
future
integrated
perspective
have
been
suggested.
A
more
complete
understanding
spatial
temporal
dynamics
host
microbial
kinds
stressors
will
enable
full
exploitation
diagnostic
therapeutic
potential
fast-evolving
field
host-microbiome
interactions.
Vaccines,
Год журнала:
2024,
Номер
12(2), С. 191 - 191
Опубликована: Фев. 13, 2024
Vaccines
are
essential
tools
to
prevent
infection
and
control
transmission
of
infectious
diseases
that
threaten
public
health.
Most
agents
enter
their
hosts
across
mucosal
surfaces,
which
make
up
key
first
lines
host
defense
against
pathogens.
Mucosal
immune
responses
play
critical
roles
in
provide
durable
better
recall
responses.
Substantial
attention
has
been
focused
on
developing
effective
vaccines
elicit
robust
localized
systemic
by
administration
via
routes.
yield
protection
superior
parenterally
delivered
vaccines.
Beyond
valuable
immunogenicity,
can
be
less
expensive
easier
administer
without
a
need
for
injection
materials
more
highly
trained
personnel.
However,
faces
many
challenges,
much
effort
directed
at
development.
In
this
article,
we
review
the
history
vaccine
development
present
an
overview
compartment
biology
immunity
plays
defending
infection,
knowledge
helped
inform
We
explore
new
progress
design
optimization
novel
approaches
created
improve
efficacy
safety
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9366 - 9366
Опубликована: Авг. 29, 2024
The
human
gastrointestinal
tract
hosts
a
complex
and
dynamic
community
of
microorganisms
known
as
the
gut
microbiota,
which
play
pivotal
role
in
numerous
physiological
processes,
including
digestion,
metabolism,
immune
function.
Recent
research
has
highlighted
significant
impact
diet
on
microbiota
composition
functionality,
consequential
effects
host
health.
Concurrently,
there
is
growing
evidence
linking
to
inflammation,
key
factor
many
chronic
diseases
such
inflammatory
bowel
disease
(IBD),
obesity,
diabetes,
cardiovascular
(CVDs).
This
review
explores
how
dietary
components
influence
composition,
these
microbial
changes
affect
pathways,
therapeutic
implications
modulating
this
axis
for
prevention
management.
Beneficial
patterns,
Mediterranean
(MD)
plant-based
diets,
promote
diverse
balanced
supporting
anti-inflammatory
pathways.
Conversely,
Western
(WD),
high
saturated
fats
refined
sugars,
associated
with
dysbiosis
increased
inflammation.
With
all
links
between
three
variables
considered,
attempts
offer
thorough
examination
triangle
formed
by
food.
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Фев. 9, 2024
The
human
brain
remains
one
of
the
greatest
challenges
for
modern
medicine,
yet
it
is
most
integral
and
sometimes
overlooked
aspects
medicine.
consists
roughly
100
billion
neurons,
trillion
neuronal
connections
consumes
about
20–25%
body’s
energy.
Emerging
evidence
highlights
that
insufficient
or
inadequate
nutrition
linked
to
an
increased
risk
health,
mental
psychological
functioning
compromise.
A
core
component
this
relationship
includes
intricate
dynamics
brain-gut-microbiota
(BGM)
system,
which
a
progressively
recognized
factor
in
sphere
mental/brain
health.
bidirectional
between
brain,
gut,
gut
microbiota
along
BGM
system
not
only
affects
nutrient
absorption
utilization,
but
also
exerts
substantial
influence
on
cognitive
processes,
mood
regulation,
neuroplasticity,
other
indices
Neuroplasticity
brain’s
capacity
adaptation
neural
regeneration
response
stimuli.
Understanding
neuroplasticity
considering
interventions
enhance
remarkable
ability
change
through
experience
constitutes
burgeoning
area
research
has
potential
improving
well-being,
resilience,
overall
health
optimal
lifestyle
interventions.
nexus
both
academic
clinical
perspectives
nutritional
neuroscience
emerges
as
potent
tool
patient
outcomes,
proactively
mitigate
challenges,
improve
management
treatment
existing
conditions
by
championing
health-promoting
dietary
patterns,
rectifying
deficiencies,
seamlessly
integrating
nutrition-centered
strategies
into
care.
Abstract
Sleep
deficiency
is
associated
with
obesity,
but
the
mechanisms
underlying
this
connection
remain
unclear.
Here,
we
identify
a
sleep-inducible
hypothalamic
protein
hormone
in
humans
and
mice
that
suppresses
obesity.
This
cleaved
from
reticulocalbin-2
(RCN2),
name
it
Raptin.
Raptin
release
timed
by
circuit
vasopressin-expressing
neurons
suprachiasmatic
nucleus
to
RCN2-positive
paraventricular
nucleus.
levels
peak
during
sleep,
which
blunted
sleep
deficiency.
binds
glutamate
metabotropic
receptor
3
(GRM3)
of
hypothalamus
stomach
inhibit
appetite
gastric
emptying,
respectively.
Raptin-GRM3
signaling
mediates
anorexigenic
effects
via
PI3K-AKT
signaling.
Of
note,
verify
connections
between
deficiencies
sleeping
state,
impaired
release,
obesity
patients
Moreover,
carrying
an
RCN2
nonsense
variant
present
night
eating
syndrome
These
data
define
unique
food
intake
prevents
