Molecules,
Год журнала:
2024,
Номер
29(23), С. 5700 - 5700
Опубликована: Дек. 2, 2024
Neurodegenerative
diseases
such
as
Alzheimer's
disease
(AD),
Parkinson's
(PD),
and
Huntington's
(HD)
have
become
a
major
global
health
burden,
but
the
detailed
pathogeneses
of
neurodegenerative
are
still
unknown,
current
treatments
mainly
aimed
at
controlling
symptoms;
there
no
curative
for
or
progressive
cognitive,
behavioral,
functional
impairments
that
they
cause.
Studies
shown
some
plant
extracts
with
pungent
flavor
components
certain
neuroprotective
effect
in
diseases,
their
mechanisms
involve
inhibiting
neuronal
apoptosis,
promoting
regeneration,
reducing
mitochondrial
degeneration,
production
oxides
reactive
oxygen
species
cells,
which
great
significance
exploring
treatment
diseases.
In
this
review,
we
searched
PubMed
database
relevant
literature
collected
past
15
years.
Finally,
summarized
protective
effects
capsaicin,
piperine,
curcumin,
cannabinoids,
allicin,
nicotine
on
nervous
system,
focusing
molecular
signaling
pathways
activate.
addition,
also
compiled
laboratory
experiments,
preclinical
various
The
goal
is
to
further
explore
potential
effective
drugs
provide
new
ideas
research
specific
these
substances
targets
drug
action
future.
Science,
Год журнала:
2025,
Номер
388(6742), С. 96 - 104
Опубликована: Апрель 4, 2025
T
cells
have
emerged
as
orchestrators
of
pain
amplification,
but
the
mechanism
by
which
control
processing
is
unresolved.
We
found
that
regulatory
(T
reg
cells)
could
inhibit
nociception
through
a
was
not
dependent
on
their
ability
to
regulate
immune
activation
and
tissue
repair.
Site-specific
depletion
or
expansion
meningeal
(mT
in
mice
led
female-specific
sex
hormone–dependent
modulation
mechanical
sensitivity.
Specifically,
mT
produced
endogenous
opioid
enkephalin
exerted
an
antinociceptive
action
delta
receptor
expressed
MrgprD
+
sensory
neurons.
Although
restrains
nociceptive
processing,
it
dispensable
for
cell–mediated
immunosuppression.
Thus,
our
findings
uncovered
sexually
dimorphic
immunological
circuit
nociception,
establishing
sentinels
homeostasis.
Allergology International,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
The
gut-brain
axis
exemplifies
the
bidirectional
connection
between
intestines
and
brain,
as
evidenced
by
impact
of
severe
stress
on
gastrointestinal
symptoms
including
abdominal
pain
diarrhea,
conversely,
influence
discomfort
mood.
Clinical
observations
support
notion
connection,
an
increased
prevalence
inflammatory
bowel
disease
(IBD)
in
patients
with
depression
anxiety,
well
association
changes
gut
microbiota
neurological
disorders
such
multiple
sclerosis,
Parkinson's
disease,
stroke
Alzheimer's
disease.
brain
communicate
via
complex
mechanisms
involving
cytokines,
immune
cells,
autonomic
nerves,
microbiota,
which
contribute
to
pathogenesis
certain
diseases.
Two
primary
pathways
mediate
information
exchange
intestinal
tract
brain:
signal
transduction
through
bloodstream
factors,
bacterial
metabolites
neural
pathways,
neurotransmitters
cytokines
within
nervous
system
interaction
nerve
cells
beyond.
In
recent
years,
basic
pathophysiology
have
been
gradually
elucidated.
Beyond
interaction,
emerging
evidence
suggests
extends
other
organs,
liver
lungs,
intricate
inter-organ
communication
pathways.
An
increasing
number
reports
this
clinical
cross-organ
interactions
underscore
potential
for
better
understanding
novel
therapeutic
strategies
targeting
inter-organs
networks.
Further
clarification
multiorgans
premises
transformative
insights
into
strategies.
