Frontiers in Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Ноя. 6, 2024
In
this
hypothesis
article,
the
potential
clinicopathological
associations
of
Calcitonin
Gene
Related
Peptide
(CGRP)
with
development
synuclein-associated
neurodegenerative
disorders
(SAND)
are
discussed.
The
presence
α
-syn
and
CGRP
in
CNS
ENS
intricate
role
its
related
pathways
inflammation,
apoptosis,
metabolism,
neuromodulation,
brain-gut
communication
analyzed.
Since
is
confirmed,
modulating
CGRP-potential
may
lead
to
novel
disease-modifying
therapies.
Science,
Год журнала:
2025,
Номер
388(6742), С. 96 - 104
Опубликована: Апрель 4, 2025
T
cells
have
emerged
as
orchestrators
of
pain
amplification,
but
the
mechanism
by
which
control
processing
is
unresolved.
We
found
that
regulatory
(T
reg
cells)
could
inhibit
nociception
through
a
was
not
dependent
on
their
ability
to
regulate
immune
activation
and
tissue
repair.
Site-specific
depletion
or
expansion
meningeal
(mT
in
mice
led
female-specific
sex
hormone–dependent
modulation
mechanical
sensitivity.
Specifically,
mT
produced
endogenous
opioid
enkephalin
exerted
an
antinociceptive
action
delta
receptor
expressed
MrgprD
+
sensory
neurons.
Although
restrains
nociceptive
processing,
it
dispensable
for
cell–mediated
immunosuppression.
Thus,
our
findings
uncovered
sexually
dimorphic
immunological
circuit
nociception,
establishing
sentinels
homeostasis.
Allergology International,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
The
gut-brain
axis
exemplifies
the
bidirectional
connection
between
intestines
and
brain,
as
evidenced
by
impact
of
severe
stress
on
gastrointestinal
symptoms
including
abdominal
pain
diarrhea,
conversely,
influence
discomfort
mood.
Clinical
observations
support
notion
connection,
an
increased
prevalence
inflammatory
bowel
disease
(IBD)
in
patients
with
depression
anxiety,
well
association
changes
gut
microbiota
neurological
disorders
such
multiple
sclerosis,
Parkinson's
disease,
stroke
Alzheimer's
disease.
brain
communicate
via
complex
mechanisms
involving
cytokines,
immune
cells,
autonomic
nerves,
microbiota,
which
contribute
to
pathogenesis
certain
diseases.
Two
primary
pathways
mediate
information
exchange
intestinal
tract
brain:
signal
transduction
through
bloodstream
factors,
bacterial
metabolites
neural
pathways,
neurotransmitters
cytokines
within
nervous
system
interaction
nerve
cells
beyond.
In
recent
years,
basic
pathophysiology
have
been
gradually
elucidated.
Beyond
interaction,
emerging
evidence
suggests
extends
other
organs,
liver
lungs,
intricate
inter-organ
communication
pathways.
An
increasing
number
reports
this
clinical
cross-organ
interactions
underscore
potential
for
better
understanding
novel
therapeutic
strategies
targeting
inter-organs
networks.
Further
clarification
multiorgans
premises
transformative
insights
into
strategies.
Immunological Reviews,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 17, 2024
Summary
The
early
development
of
the
neonatal
immune
system
is
profoundly
influenced
by
exposure
to
dietary
and
microbial
antigens,
which
shapes
mucosal
tolerance.
Successful
oral
tolerance
induction
crucially
dependent
on
microbially
imprinted
cells,
most
notably
RORγt
+
regulatory
T
(Treg)
antigen
presenting
cells
essential
for
preventing
food
allergy
(FA).
FA
can
be
envisioned
result
from
disruptions
at
key
checkpoints
(CKPTs)
that
govern
induction.
These
include
gut
epithelial
sensory
effector
circuits
when
dysregulated
promote
pro‐allergic
dysbiosis.
They
also
are
disrupted
dysbiosis
responses
unleashed
dysregulation
aforementioned
cascades.
Understanding
these
developing
therapeutic
strategies
restore
homeostasis
in
FA.
