An overview of potential of natural compounds to regulate epigenetic modifications in colorectal cancer: a recent update DOI Creative Commons
Susmita Roy, Dikshita Deka, K. Suresh Babu

и другие.

Epigenetics, Год журнала: 2025, Номер 20(1)

Опубликована: Апрель 16, 2025

Colorectal cancer (CRC) remains an alarming global health concern despite advancements in treatment modalities over recent decades. Among the various factors contributing to CRC, this review emphasizes critical role of epigenetic mechanisms its pathogenesis and progression. This also describes potential natural compounds altering landscape, focused mainly on DNA methylation, histone modification, non-coding RNAs. Publications from previous five years were searched retrieved using well-known search engines databases like PubMed, Google Scholar, ScienceDirect. Keywords CRC/colorectal cancer, CAC/Colitis associated inflammasomes, modulation, genistein, curcumin, quercetin, resveratrol, anthocyanins, sulforaphane, epigallocatechin-3-gallate used combinations during search. These predominantly affect pathways such as Wnt/β-catenin, NF-κB, PI3K/AKT suppress CRC cell proliferation oxidative stress enhance anti-inflammation apoptosis. However, their clinical use is restricted due low bioavailability. multiple methods exist overcome challenges this, including but not limited structural modifications, nanoparticle encapsulations, bio-enhancers, novel advanced delivery systems. improve supportive therapies that target progression epigenetically with fewer side effects. Current research focuses enhancing targeting control while minimizing effects, emphasizing improved specificity, bioavailability, efficacy standalone or synergistic therapies.

Язык: Английский

The role of interleukin-17 in inflammation-related cancers DOI Creative Commons
Xingru Zhang, Bin Li, Lü Tian

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 15

Опубликована: Янв. 21, 2025

Emerging evidence indicates a correlation between inflammation and the development progression of cancer. Among various inflammatory signals, interleukin-17 (IL-17) family cytokines serve as critical link IL-17 is highly versatile pro-inflammatory cytokine that plays pivotal role in host defense, tissue repair, pathogenesis diseases, cancer progression. During early stages tumorigenesis, signaling directly promotes proliferation tumor cells. Conversely, has been shown to exhibit antitumor immunity several models grafted subcutaneous tumors. Additionally, dynamic changes microbiome can influence secretion IL-17, thereby affecting development. The specific contingent upon its functional classification, spatiotemporal characteristics, stage In this review, we introduce fundamental biology expression profile receptors cancer, while also reviewing discussing recent advancements regarding pleiotropic effects mechanisms inflammation-related cancers. Furthermore, supplement our discussion with insights into by which impacts through interactions microbiota, explore implications therapy. This comprehensive analysis aims enhance understanding potential treatment.

Язык: Английский

Процитировано

4
The Role of Inflammation in Cancer: Mechanisms of Tumor Initiation, Progression, and Metastasis DOI Creative Commons
Atsushi Nishida, Akira Andoh

Cells, Год журнала: 2025, Номер 14(7), С. 488 - 488

Опубликована: Март 25, 2025

Inflammation is an essential component of the immune response that protects host against pathogens and facilitates tissue repair. Chronic inflammation a critical factor in cancer development progression. It affects every stage tumor development, from initiation promotion to invasion metastasis. Tumors often create inflammatory microenvironment induces angiogenesis, suppression, malignant growth. Immune cells within interact actively with cells, which drives progression through complex molecular mechanisms. triggered by factors such as infections, obesity, environmental toxins strongly linked increased risk. However, acute responses can sometimes boost antitumor immunity; thus, presents both challenges opportunities for therapeutic intervention. This review examines how contributes biology, emphasizing its dual role tumorigenesis potential target.

Язык: Английский

Процитировано

3
Chronic Gastrointestinal Disorders and miRNA-Associated Disease: An Up-to-Date DOI Open Access
Alessandro Giammona, Bruno G. Galuzzi, Elena Imperia

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(1), С. 413 - 413

Опубликована: Янв. 6, 2025

Chronic gastrointestinal disorders such as inflammatory bowel diseases (IBDs) and irritable syndrome (IBS) impose significant health burdens globally. IBDs, encompassing Crohn’s disease ulcerative colitis, are multifactorial characterized by chronic inflammation of the tract. On other hand, IBS is one principal tract functional abdominal pain altered habits. Although precise etiopathogenesis these remains unclear, mounting evidence suggests that non-coding RNA molecules play crucial roles in regulating gene expression associated with inflammation, apoptosis, oxidative stress, tissue permeability, thus influencing progression. miRNAs have emerged possible reliable biomarkers, they can be analyzed biological fluids patients at a low cost. This review explores IBDs IBS, focusing on their involvement control hallmarks. By an extensive literature employing bioinformatics tools, we identified frequently studied concerning diseases. Ultimately, specific could proposed diagnostic biomarkers for IBS. Their ability to secreted into biofluids makes them promising candidates non-invasive tools. Therefore, understanding molecular mechanisms through ways which regulate immune responses provide new insights pathogenesis open avenues miRNA-based therapeutic interventions.

Язык: Английский

Процитировано

1
Inflammation and cancer: molecular mechanisms and clinical consequences DOI Creative Commons
Hikmet Akkız, Cem Şimşek, Deniz Balcı

и другие.

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Март 17, 2025

Inflammation, a hallmark of cancer, has been associated with tumor progression, transition into malignant phenotype and efficacy anticancer treatments in cancer. It affects all stages from the initiation carcinogenesis to metastasis. Chronic inflammation induces immunosup-pression, providing an environment conducive carcinogenesis, whereas acute antitumor immune response, leading suppression. Solid tumors have inflammatory microenvironment (TME) containing cancer cells, stromal soluble molecules, which plays key role progression therapy response. Both cells TME are highly plastic constantly change their phenotypic functional properties. Cancer-associated inflammation, majority consists innate important cell plasticity, development drug resistance. Today, combined used advanced technologies, such as single-cell RNA sequencing spatial molecular imaging analysis, pathways linking chronic largely elucidated. In this review article, we highlighted cellular mechanisms involved cancer-associated its effects on treatment We also comprehensively setting GI cancers.

Язык: Английский

Процитировано

1
C1Q+ TPP1+ macrophages promote colon cancer progression through SETD8-driven p53 methylation DOI Creative Commons
Veronica Veschi, Francesco Verona, Sebastiano Di Bella

и другие.

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Март 31, 2025

In many tumors, the tumor suppressor TP53 is not mutated, but functionally inactivated. However, mechanisms underlying p53 functional inactivation remain poorly understood. SETD8 sole enzyme known to mono-methylate on lysine 382 (p53K382me1), resulting in inhibition of its pro-apoptotic and growth-arresting functions. We analyzed p53K382me1 expression clinical colorectal cancer (CRC) inflammatory bowel disease (IBD) samples. Histopathological examinations, RNA sequencing, ChIP assay preclinical vivo CRC models, were used assess role cells immune cell infiltration. By integrating bulk RNAseq scRNAseq approaches patients, SETD8-mediated regulation resulted most significantly enriched pathway. was confined stem (CR-CSCs) C1Q+ TPP1+ tumor-associated macrophages (TAMs) patient tissues, with high levels predicting decreased survival probability. TAMs promote CR-CSCs through IL-6 MCP-1 secretion increased CEBPD, which directly binds promoter thus enhancing transcription. The direct binding C1Q present receptor (C1QR) mediates cross-talk between two compartments. As monotherapy, genetic pharmacological (UNC0379) affects growth metastasis formation mouse avatars, enhanced effects observed when combined targeting. These findings suggest that may be an early step initiation, especially inflammation-induced CRC, could serve as a biomarker therapeutic target adjuvant setting for advanced CRCs.

Язык: Английский

Процитировано

1
Current understandings of colibactin regulation DOI
Emily Addington, Sofia Sandalli, Andrew J. Roe

и другие.

Microbiology, Год журнала: 2024, Номер 170(2)

Опубликована: Фев. 5, 2024

Graphical Abstract

Язык: Английский

Процитировано

7
AGA Clinical Practice Update on Management of Inflammatory Bowel Disease in Patients With Malignancy: Commentary DOI
Jordan E. Axelrad, Jana G. Hashash, Steven H. Itzkowitz

и другие.

Clinical Gastroenterology and Hepatology, Год журнала: 2024, Номер 22(7), С. 1365 - 1372

Опубликована: Май 14, 2024

Язык: Английский

Процитировано

5
Revisiting Luteolin Against the Mediators of Human Metastatic Colorectal Carcinoma: A Biomolecular Approach DOI
Ankita Chakraborty,

Advaitha Midde,

Pritha Chakraborty

и другие.

Journal of Cellular Biochemistry, Год журнала: 2024, Номер 126(1)

Опубликована: Сен. 20, 2024

ABSTRACT Metastatic colorectal carcinoma (mCRC) is one of the prevalent subtypes human cancers and caused by alterations various lifestyle diet‐associated factors. β‐catenin, GSK‐3β, PI3K‐α, AKT1, NF‐κB p50 are known to be critical regulators tumorigenesis immunopathogenesis mCRC. Unfortunately, current drugs have limited efficacy, side effects can lead chemoresistance. Therefore, searching for a nontoxic, efficacious anti‐mCRC agent crucial utmost interest. The present study demonstrates identification productive nontoxic through five‐targets (β‐catenin, p50)‐based three‐tier (binding affinity, pharmacokinetics, pharmacophore) screening strategy involving series 30 phytocompounds having background anti‐inflammatory/anti‐mCRC efficacy alongside 5‐fluorouracil (FU), reference drug. Luteolin (a phyto‐flavonoid) was eventually rendered as most potent safe phytocompound. This inference verified three rounds validation. Firstly, luteolin found effective against different mCRC cell lines (HCT‐15, HCT‐116, DLD‐1, HT‐29) without hampering viability non‐tumorigenic ones (RWPE‐1). Secondly, curtail clonogenicity CRC cells, finally, it also disrupted formation colospheroids, characteristic metastasis. While studying mechanistic insights, inhibit β‐catenin activity key regulator mCRC) direct physical interactions, promoting its degradation activating GSK3‐β ceasing activation inactivating AKT1 PI3K‐α. inhibited activity, which could useful in mitigating mCRC‐associated proinflammatory milieu. In conclusion, our provides evidence on recommends further studies animal models determine effectiveness this natural compound treating future.

Язык: Английский

Процитировано

5
Inflammatory bowel disease, colitis, and cancer: unmasking the chronic inflammation link DOI Creative Commons
Vahid Khaze, Saeed Noorolyai, Mahya Ahmadpour Youshanlui

и другие.

International Journal of Colorectal Disease, Год журнала: 2024, Номер 39(1)

Опубликована: Окт. 28, 2024

Chronic inflammation is a significant driver in the development of various diseases, including cancer. Colitis-associated colorectal cancer (CA-CRC) refers to increased risk individuals with chronic inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease. This narrative review examines link between CA-CRC. A comprehensive literature search was conducted using PubMed, Scopus, Web Science, focusing on studies published 2000 2024. Studies were selected based relevance role CA-CRC, specifically targeting molecular pathways clinical implications. Both mechanistic reviewed. Sustained colon fosters pro-tumorigenic environment, leading initiation progression Prevention strategies must focus controlling inflammation, optimizing IBD management, implementing regular screenings. Emerging therapies key immune responses, along microbiome modulation, hold promise for reducing CA-CRC risk. Understanding these mechanisms provides path toward personalized treatment better outcomes patients at

Язык: Английский

Процитировано

5
Genetics, diet, microbiota, and metabolome: partners in crime for colon carcinogenesis DOI Creative Commons
Marta La Vecchia,

G. Sala,

Marika Sculco

и другие.

Clinical and Experimental Medicine, Год журнала: 2024, Номер 24(1)

Опубликована: Окт. 29, 2024

Colorectal cancer (CRC) ranks among the most prevalent malignant tumors worldwide, with a multifactorial etiology encompassing genetic, environmental, and life-style factors, as well intestinal microbiota its metabolome. These risk factors often work together in specific groups of patients, influencing how CRC develops progresses. Importantly, alterations gut act critical nexus this interplay, significantly affecting susceptibility to CRC. This review highlights recent insights into unmodifiable modifiable for they might interact Understanding mechanisms these interactions will help us develop targeted, precision-medicine strategies that can adjust composition meet individual health needs, preventing or treating more effectively.

Язык: Английский

Процитировано

5