Biomarkers in Different Asthma Phenotypes DOI Open Access
Sanja Popović‐Grle,

Anamarija Štajduhar,

Marina Lampalo

и другие.

Genes, Год журнала: 2021, Номер 12(6), С. 801 - 801

Опубликована: Май 25, 2021

Asthma is the most common respiratory disease. It has multiple phenotypes thatcan be partially differentiated by measuring disease's specific characteristics-biomarkers. The pathogenetic mechanisms are complex, and it still a challenge to choose suitable biomarkers adequately stratify patients, which became especially important with introduction of biologicals in asthma treatment. Usage an understanding underlying pathobiological lead definition endotypes. can broadly divided into two endotypes, T2-high T2-low. right combination various different under investigation, hoping help researchers clinicians better disease evaluation since theindividual approach personalized medicine imperative. Multiple superior single biomarker.

Язык: Английский

Transdermally delivered tolerogenic nanoparticles induced effective immune tolerance for asthma treatment DOI

Jiaxuan Zhao,

Penghui He,

Min Jiang

и другие.

Journal of Controlled Release, Год журнала: 2024, Номер 366, С. 637 - 649

Опубликована: Янв. 18, 2024

Язык: Английский

Процитировано

7
Wogonoside Ameliorates Airway Inflammation and Mucus Hypersecretion via NF-κB/STAT6 Signaling in Ovalbumin-Induced Murine Acute Asthma DOI
Xiu Yu,

Bicheng Cai,

Li Yu

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(13), С. 7033 - 7042

Опубликована: Март 20, 2024

Asthma is recognized as a chronic respiratory illness characterized by airway inflammation and hyperresponsiveness. Wogonoside, flavonoid glycoside, reported to significantly alleviate the response oxidative stress. Herein, this study aimed investigate therapeutic effect underlying mechanism of wogonoside on mucus hypersecretion in murine asthma model human bronchial epithelial cells (16HBE). BALB/c mice were sensitized challenged with ovalbumin (OVA). Pulmonary function number bronchoalveolar lavage fluid (BALF) examined. Pathological changes lung tissue each group evaluated via hematoxylin eosin periodic acid–Schiff staining, levels cytokines BALF immunoglobulin E serum determined an enzyme-linked immunosorbent assay. The expression relevant genes was analyzed real-time PCR. Western blotting immunofluorescence employed detect proteins 16HBE cells. Treatment 10 20 mg/kg attenuated OVA-induced increase inflammatory cell infiltration, secretion, goblet percentage improved pulmonary function. Wogonoside treatment reduced level T-helper 2 including interleukin (IL)-4, IL-5, IL-13 IgE decreased mRNA (IL-4, IL-6, IL-13, IL-1β tumor necrosis factor-α), chemokines (CCL-2, CCL-11, CCL-24), mucoproteins (MUC5AC, MUC5B, GOB5) tissues. MUC5AC phosphorylation STAT6 NF-κB p65 tissues downregulated after treatment. Thus, may effectively decrease inflammation, remodeling, blocking NF-κB/STAT6 activation.

Язык: Английский

Процитировано

7
Emerging mechanisms contributing to mast cell-mediated pathophysiology with therapeutic implications DOI
Guido H. Falduto, Annika Pfeiffer, Andrea Luker

и другие.

Pharmacology & Therapeutics, Год журнала: 2020, Номер 220, С. 107718 - 107718

Опубликована: Окт. 30, 2020

Язык: Английский

Процитировано

41
Flavonoids isolated from loquat (Eriobotrya japonica) leaves inhibit oxidative stress and inflammation induced by cigarette smoke in COPD mice: the role of TRPV1 signaling pathways DOI
Tunyu Jian, Jian Chen, Xiaoqin Ding

и другие.

Food & Function, Год журнала: 2020, Номер 11(4), С. 3516 - 3526

Опубликована: Янв. 1, 2020

Total flavonoids isolated from loquat leaves inhibit inflammation and oxidative stress by regulating TRPV1 the related pathway in cigarette smoke-induced COPD mice.

Язык: Английский

Процитировано

40
Biomarkers in Different Asthma Phenotypes DOI Open Access
Sanja Popović‐Grle,

Anamarija Štajduhar,

Marina Lampalo

и другие.

Genes, Год журнала: 2021, Номер 12(6), С. 801 - 801

Опубликована: Май 25, 2021

Asthma is the most common respiratory disease. It has multiple phenotypes thatcan be partially differentiated by measuring disease's specific characteristics-biomarkers. The pathogenetic mechanisms are complex, and it still a challenge to choose suitable biomarkers adequately stratify patients, which became especially important with introduction of biologicals in asthma treatment. Usage an understanding underlying pathobiological lead definition endotypes. can broadly divided into two endotypes, T2-high T2-low. right combination various different under investigation, hoping help researchers clinicians better disease evaluation since theindividual approach personalized medicine imperative. Multiple superior single biomarker.

Язык: Английский

Процитировано

40