Effects of exercise on circadian rhythms in humans

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Окт. 11, 2023

The biological clock system is an intrinsic timekeeping device that integrates internal physiology and external cues. Maintaining a healthy crucial for life. Disruptions to the body’s can lead disturbances in sleep-wake cycle abnormalities hormone regulation, blood pressure, heart rate, other vital processes. Long-term have been linked development of various common major diseases, including cardiovascular metabolic disorders, tumors, neuropsychiatric conditions, so on. External factors, such as diurnal rhythm light, significant impact on clock. Additionally, important non-photic zeitgeber, exercise regulate rhythms certain extent, making it possible become non-drug intervention preventing treating circadian disorders. This comprehensive review encompasses behavioral, physiological, molecular perspectives provide deeper understanding how influences its association with related diseases.

Язык: Английский

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The Relationship between Circadian Rhythm and Cancer Disease

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 5846 - 5846

Опубликована: Май 28, 2024

The circadian clock regulates biological cycles across species and is crucial for physiological activities biochemical reactions, including cancer onset development. interplay between the rhythm involves regulating cell division, DNA repair, immune function, hormonal balance, potential chronotherapy. This highlights importance of maintaining a healthy prevention treatment. article investigates complex relationship cancer, exploring how disruptions to internal may contribute tumorigenesis influence progression. Numerous databases are utilized conduct searches articles, such as NCBI, MEDLINE, Scopus. keywords used throughout academic archives “circadian rhythm”, ”cancer”, ”circadian clock”. Maintaining cycle prioritizing sleep habits minimizing disruptions, consistent schedules, reduced artificial light exposure, meal timing adjustments. Dysregulation gene can cause tumor growth, leading need regulate better treatment outcomes. components significantly impact cellular responses damage, influencing Understanding rhythm’s role in diseases their therapeutic targets essential treating preventing cancer. Disruptions promote abnormal development metastasis, potentially due system imbalances fluctuations.

Язык: Английский

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Three‐dimensional printed biomimetic multilayer scaffolds coordinated with sleep‐related small extracellular vesicles: A strategy for extracellular matrix homeostasis and macrophage polarization to enhance osteochondral regeneration

View, Год журнала: 2024, Номер 5(2)

Опубликована: Янв. 10, 2024

Abstract Cartilage defects resulting from injury or degeneration are a common clinical problem, and due to its avascular nature, articular cartilage has poor self‐healing capacity. Three‐dimensional (3D) bioprinting attracted great attention in tissue engineering. Melatonin (MT), hormone mainly secreted at night, plays an important role repair. Small extracellular vesicles (sEV) considered ideal drug delivery vehicles MT‐sEV (sleep‐related sEV) have the potential ability promote regeneration. Here, biomimetic multilayer scaffolds were fabricated using 3D bioprinting. A double network hydrogel, composed of methacrylated hyaluronic acid gelatin methacryloyl (HG), was prepared. HG hydrogel used create layer. bone layer formed poly(ε‐caprolactone) hydroxyapatite ultralong nanowires. Additionally, two bioinks alternately printed interface The results RNA sequencing revealed regulatory mechanisms. showed promotional effects on cell migration, proliferation, chondrogenic differentiation, matrix (ECM) deposition. Moreover, altered macrophage polarization regulated expression inflammatory cytokines. In vivo experiments demonstrated that promoted These regulate immune microenvironment secretion ECM, providing promising strategy for

Язык: Английский

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The role of circadian clock in regulating cell functions: implications for diseases

MedComm, Год журнала: 2024, Номер 5(3)

Опубликована: Март 1, 2024

Abstract The circadian clock system orchestrates daily behavioral and physiological rhythms, facilitating adaptation to environmental internal oscillations. Disruptions in rhythms have been linked increased susceptibility various diseases can exacerbate existing conditions. This review delves into the intricate regulation of diurnal gene expression cell function by clocks across diverse tissues. . Specifically, we explore rhythmicity expressions, behaviors, functions both immune non‐immune cells, elucidating regulatory effects mechanisms imposed clocks. A detailed discussion is centered on complex regulating key cellular signaling pathways. We further diseases, with a focus inflammatory cancers, systemic diseases. By highlighting intimate interplay between especially through clock‐controlled function, this contributes development novel disease intervention strategies. enhanced understanding holds significant promise for design targeted therapies that exploit improved treatment efficacy.

Язык: Английский

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The interplay between the PI3K/AKT pathway and circadian clock in physiologic and cancer‐related pathologic conditions

Cell Proliferation, Год журнала: 2024, Номер 57(7)

Опубликована: Фев. 9, 2024

Abstract The circadian clock is responsible for the regulation of different cellular processes, and its disturbance has been linked to development diseases, such as cancer. main molecular mechanism this issue crosstalk between core regulators intracellular pathways cell survival. PI3K/AKT signalling pathway one most known in case cancer initiation progression. This regulates aspects survival including proliferation, apoptosis, metabolism, response environmental stimuli. Accumulating evidence indicates that there a link activity rhythm physiologic cancer‐related pathogenesis. Different classes PI3Ks AKT isoforms are involved regulating components transcriptional functional manner. Reversely, induce rhythmic fashion PI3K pathogenic conditions. aim review re‐examine interplay normal condition pathogenesis, which provides better understanding how rhythms may be

Язык: Английский

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Disrupting circadian control of autophagy induces podocyte injury and proteinuria

Kidney International, Год журнала: 2024, Номер 105(5), С. 1020 - 1034

Опубликована: Фев. 21, 2024

The circadian clock influences a wide range of biological process and controls numerous aspects physiology to adapt the daily environmental changes caused by Earth's rotation. kidney plays an important role in maintaining tubular function, but its effect on podocytes remains unclear. Here, we found that expressed CLOCK proteins, 2666 glomerular gene transcripts (13.4%), including autophagy related genes, had 24-hour rhythms. Deletion Clock resulted 1666 with loss rhythm genes. Podocyte-specific knockout mice at age three eight months showed deficient autophagy, increased albuminuria. Chromatin immunoprecipitation (ChIP) sequence analysis indicated genes were targets podocytes. ChIP-PCR further confirmed binding promoter regions Becn1 Atg12, two Furthermore, association regulated chronic sleep fragmentation diabetic disease was analyzed. Chronic rhythm, inhibition podocyte proteinuria. Rhythmic oscillations also disappeared high glucose treated glomeruli from mice. Finally, differences abolished aggravated injury proteinuria Thus, our findings demonstrate clock-dependent regulation may be essential for survival. Hence. controlled play

Язык: Английский

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Natural Compounds for Preventing Age-Related Diseases and Cancers

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(14), С. 7530 - 7530

Опубликована: Июль 9, 2024

Aging is a multifaceted process influenced by hereditary factors, lifestyle, and environmental elements. As time progresses, the human body experiences degenerative changes in major functions. The external internal signs of aging manifest various ways, including skin dryness, wrinkles, musculoskeletal disorders, cardiovascular diseases, diabetes, neurodegenerative cancer. Additionally, cancer, like aging, complex disease that arises from accumulation genetic epigenetic alterations. Circadian clock dysregulation has recently been identified as an important risk factor for cancer development. Natural compounds herbal medicines have gained significant attention their potential preventing age-related diseases inhibiting progression. These demonstrate antioxidant, anti-inflammatory, anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects well circadian regulation. This review explores cancers, specific natural targeting key features these conditions.

Язык: Английский

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Wearables in Chronomedicine and Interpretation of Circadian Health

Diagnostics, Год журнала: 2025, Номер 15(3), С. 327 - 327

Опубликована: Янв. 30, 2025

Wearable devices have gained increasing attention for use in multifunctional applications related to health monitoring, particularly research of the circadian rhythms cognitive functions and metabolic processes. In this comprehensive review, we encompass how wearables can be used study disease. We highlight importance these as markers well-being potential predictors outcomes. focus on wearable technologies sleep research, medicine, chronomedicine beyond domain emphasize actigraphy a validated tool monitoring sleep, activity, light exposure. discuss various mathematical methods currently analyze actigraphic data, such parametric non-parametric approaches, linear, non-linear, neural network-based applied quantify non-circadian variability. also introduce novel actigraphy-derived markers, which personalized proxies status, assisting discriminating between disease, offering insights into neurobehavioral status. lifestyle factors physical activity exposure modulate brain health. establishing reference standards measures further refine data interpretation improve clinical The review calls existing tools methods, deepen our understanding health, develop healthcare strategies.

Язык: Английский

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From population-based to personalized laboratory medicine: continuous monitoring of individual laboratory data with wearable biosensors

Critical Reviews in Clinical Laboratory Sciences, Год журнала: 2025, Номер unknown, С. 1 - 30

Опубликована: Фев. 1, 2025

Monitoring individuals' laboratory data is essential for assessing their health status, evaluating the effectiveness of treatments, predicting disease prognosis and detecting subclinical conditions. Currently, monitoring performed intermittently, measuring serum, plasma, whole blood, urine occasionally other body fluids at predefined time intervals. The ideal approach entails continuous measurement concentration activity biomolecules in all fluids, including solid tissues. This can be achieved through use biosensors strategically placed various locations on human where measurements are required monitoring. High-tech wearable provide an ideal, noninvasive, esthetically pleasing solution data. However, despite significant advances biosensor technology, capacities number different analytes that continuously monitored patients not yet desired level. In this review, we conducted a literature search examined: (i) overview background personalized medicine, (ii) used individuals, (iii) types methods biomolecules, (iv) statistical algorithms analysis interpretation evaluation.

Язык: Английский

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A Transcriptomic Dataset of Liver Tissues from Global and Liver-Specific Bmal1 Knockout Mice

Scientific Data, Год журнала: 2025, Номер 12(1)

Опубликована: Фев. 3, 2025

The circadian clock regulates various physiological processes in mammals. core gene Bmal1 is crucial for maintaining the oscillations of system by controlling rhythmic expression numerous clock-controlled genes. To explore transcriptional changes associated with deletion liver tissues, we collected tissues from global and liver-specific knockout mice, along their respective control groups, at two time points (CT2 CT14) used them transcriptome sequencing analysis. Genotyping, locomotor activity analysis, comprehensive quality analyses, including base scores, GC content, mapping rates, confirmed high data. Differential analysis RT-qPCR validation reliability validity dataset. These data offer a valuable resource researchers investigating role BMAL1 physiology, pathology, broader field biology.

Язык: Английский

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