International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(7), С. 3694 - 3694
Опубликована: Март 26, 2024
Metabolic-associated fatty liver disease (MAFLD) includes several metabolic dysfunctions caused by dysregulation in the brain–gut–liver axis and, consequently, increases cardiovascular risks and dysfunction. In MAFLD, type 2 diabetes mellitus, obesity, syndrome are frequently present; these conditions related to lipogenesis systemic inflammation. This study aimed review connection between MAFLD. The inflammatory process, cellular alterations hepatocytes stellate cells, hypercaloric diet, sedentarism aggravate prognosis of patients with Thus, understand modulation physiopathology it is necessary include organokines involved this process (adipokines, myokines, osteokines, hepatokines) their clinical relevance project future perspectives condition bring light new possibilities therapeutic approaches. Adipokines responsible for activation distinct signaling different tissues, such as insulin pro-inflammatory cytokines, which important balancing substances avoid MAFLD its progression. Myokines improve quantity quality adipose contributing avoiding development Finally, hepatokines decisive improving or not progression through regulation anti-inflammatory organokines.
Язык: Английский
Процитировано
12Metabolic-Associated Fatty Liver Disease: The Influence of Oxidative Stress, Inflammation, Mitochondrial Dysfunctions, and the Role of Polyphenols
Pharmaceuticals, Год журнала: 2024, Номер 17(10), С. 1354 - 1354
Опубликована: Окт. 10, 2024
Metabolic-Associated Fatty Liver Disease (MAFLD) is a clinical-pathological scenario that occurs due to the accumulation of triglycerides in hepatocytes which considered significant cause liver conditions and contributes an increased risk death worldwide. Even though possible causes MAFLD can involve interaction genetics, hormones, nutrition, lifestyle (diet sedentary lifestyle) most influential factor developing this condition. Polyphenols comprise many natural chemical compounds be helpful managing metabolic diseases. Therefore, aim review was investigate impact oxidative stress, inflammation, mitochondrial dysfunction, role polyphenols MAFLD. Some reverse part damage related or among them are anthocyanin, baicalin, catechin, curcumin, chlorogenic acid, didymin, epigallocatechin-3-gallate, luteolin, mangiferin, puerarin, punicalagin, resveratrol, silymarin. These have actions reducing plasma enzymes, body mass index, waist circumference, adipose visceral indices, lipids, glycated hemoglobin, insulin resistance, HOMA index. They also reduce nuclear factor-KB (NF-KB), interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), blood pressure, fat content, steatosis fibrosis. On other hand, they improve HDL-c, adiponectin levels, fibrogenesis markers. results show promising prevention treatment
Язык: Английский
Процитировано
8Mediterranean vs. Western diet effects on the primate cerebral cortical pre‐synaptic proteome: Relationships with the transcriptome and multi‐system phenotypes
Alzheimer s & Dementia, Год журнала: 2025, Номер 21(3)
Опубликована: Март 1, 2025
Abstract INTRODUCTION Diet quality mediates aging‐related risks of cognitive decline, neurodegeneration, and Alzheimer's disease (AD) through poorly defined mechanisms. METHODS The effects diet on the presynaptic proteome temporal cortex were assessed in 36 female cynomolgus macaques randomized to Mediterranean or Western diets for 31 months. Associations between proteome, determined by synaptometry time‐of‐flight (SynTOF) mass spectrometry, adjacent transcriptome, multi‐system phenotypes using a machine learning approach. RESULTS Six proteins (DAT, Aβ42, calreticulin, LC3B, K48‐Ubiquitin, SLC6A8) elevated consumers ( p < 0.05). Transcriptomic data significantly predicted SynTOF markers. Selected markers correlated with changes white matter volumes, hepatosteatosis, behavioral physiological measures psychosocial stress. DISCUSSION These observations demonstrate that composition drives cortical protein composition, transcriptional profiles strongly predict proteomic profile, closely associated peripheral metabolism, stress responsivity, neuroanatomy, socio‐emotional behavior. Highlights differentially altered which is neurodegeneration decline. Presynaptic transcriptomic cortex, anatomical, physiologic, phenotypes. brain brain‐body interactions are influenced common dietary patterns, suggesting improving may be an effective means maintain health.
Язык: Английский
Процитировано
0Early stage of metabolic dysfunction associated steatotic liver disease disrupts circadian rhythm and induces neuroinflammation in rats
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Март 27, 2025
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is a chronic liver disease affecting 25% of the European population, with rising global incidence. damage includes ballooning, steatosis, inflammation and fibrosis. Associated brain disorders include sleep, cognitive issues, anxiety, depression. While neurological complications in advanced MASLD are well documented, early cerebral manifestations remain largely unexplored. This study aimed at developing an rat model to assess onset damage, focusing on impairments circadian cycle rhythm associated neuroinflammation. Sprague Dawley rats were divided into two groups: one received high-fat, high-cholesterol (HFHC) diet for 90 days, while other standard diet. Histological analysis showed significant hepatic HFHC group (p < 0.01). These lesions correlated elevated triglycerides 0.01), increased Alanine Aminotransferase, Aspartate total cholesterol, low-density lipoprotein, alongside decreased plasma high-density lipoprotein. Behavioural using activity wheels revealed that steadily maintained their level during rest periods when compared controls 0.05). behavioural alteration occurred neuroinflammation, demonstrated by changes expression 36 17 inflammatory mediators cerebellum frontal cortex respectively. increase glial cell markers (Aif1 Gfap genes) number microglial cells, differently. shows disturbances, which could reflect sleep humans. disturbances specific MASLD, occur before symptoms become clinically apparent, therefore be used as diagnosis marker patients.
Язык: Английский
Процитировано
0Endurance Exercise Training Alleviates Hepatic Lipocalin‐2 Release and Prevents Anxiety‐Like Disorders in Chronically Stressed Mice
Advanced Biology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 8, 2025
Abstract Exercise training can prevent anxiety disorders in both rodent models and human cohorts. The involvement of peripheral factors exercise‐mediated mental health is being appreciated. It recently shown that the hepatic biosynthesis lipocalin‐2 (LCN2) respond to chronic restraint stress (CRS) elicit anxiety‐like behaviors via inhibiting neural activity medial prefrontal cortex (mPFC). Here, it found 14‐day treadmill exercise ameliorates these CRS‐treated mice. Further assays show intervention reduces release LCN2. Meanwhile, may also counteract adverse effect LCN2 relieving cortical microglial cell proliferation. results collectively suggest modulate liver‐brain axis reshape for preventing disorders.
Язык: Английский
Процитировано
0The association between liver fibrosis score and incident dementia: A nationwide retrospective cohort study
Alzheimer s & Dementia, Год журнала: 2024, Номер 20(8), С. 5385 - 5397
Опубликована: Июль 1, 2024
Abstract BACKGROUND We assessed the relationship of liver fibrosis score with incident dementia in a large, national sample. METHODS For this retrospective cohort study, data dementia‐free individuals aged 40‐69 years were derived from electronic records largest healthcare provider Israel. The association between (FIB‐4), routine laboratory measurements, and was explored through multivariate cox regression models. RESULTS Of total sample ( N = 826,578, mean age 55 ± 8 at baseline), 636,967 (77%) had no fibrosis, 180,114 (21.8%) inconclusive status 9497 (1.2%) high risk for advanced fibrosis. Over median follow‐up 17 years, 41,089 cases recorded. Inconclusive associated increased (HR 1.09, 95%CI: 1.07–1.11 HR 1.18, 1.10–1.27, respectively). This remained robust seven sensitivity analyses. CONCLUSIONS Liver serum‐based algorithm may serve as factor general population. Highlights predict diagnosis 9% risk. Advanced 18% Findings analyses after adjustments.
Язык: Английский
Процитировано
2Modulation of Δ5- and Δ6-desaturases in the brain-liver axis
Nutrition, Год журнала: 2024, Номер 131, С. 112629 - 112629
Опубликована: Ноя. 12, 2024
Язык: Английский
Процитировано
2Interaction between trouble sleeping and diabetes on metabolic dysfunction-associated fatty liver disease and liver fibrosis in adults results from the National Health and Nutrition Examination Survey 2017–2018
European Journal of Gastroenterology & Hepatology, Год журнала: 2024, Номер 36(12), С. 1437 - 1446
Опубликована: Сен. 27, 2024
Metabolic dysfunction-associated fatty liver disease (MAFLD), trouble sleeping, and diabetes, as major public health problems, were closely related. The study examined the interaction between sleeping diabetes on MAFLD fibrosis in adults with MAFLD.
Язык: Английский
Процитировано
1Investigating the Possible Ameliorating Impact of Black Seed (Nigella sativa) Hydroethanolic Extract on Liver and Brain Tissue in a Rat Model of Polycystic Ovary
Annals of Military and Health Sciences Research, Год журнала: 2024, Номер 22(2)
Опубликована: Июнь 16, 2024
Background: Polycystic ovary syndrome (PCOS) is the most frequent endocrine disorder in women of reproductive age, which may affect various organs, including brain and liver. Objectives: This study aimed to investigate potential ameliorating effects black seed (Nigella sativa) hydroethanolic extract on liver tissues a rat model polycystic ovary. Methods: In this experimental study, eighteen female rats were divided into three groups: Control (PCO day 0 after induction PCO), vehicle receiving saline via gavage for 28 days), (BSE) BSE days). was induced by single intraperitoneal injection 2 mg/kg estradiol valerate. Liver tissue evaluated average number damaged hepatocytes (segmented nucleus cytoplasm shrinkage), Kupffer cells, lipid droplets, while assessed vacuolization, apoptosis, cell shrinkage. Results: group, weight significantly decreased, increased compared control groups. Moreover, there significant decrease cells group tissue. tissue, reduction vacuolations group. Conclusions: Black demonstrated adverse impacts PCO (reducing cells) vacuolations). Further histologic molecular analyses are needed protective thoroughly.
Язык: Английский
Процитировано
0Metabolic-Associated Fatty Liver Disease and Cognitive Performance in Type 2 Diabetes: Basal Data from the Phytate, Neurodegeneration and Diabetes (PHYND) Study
Biomedicines, Год журнала: 2024, Номер 12(9), С. 1993 - 1993
Опубликована: Сен. 2, 2024
The effect of liver fibrosis on mild cognitive impairment (MCI) and dementia risk in type 2 diabetes mellitus (T2DM) patients is unclear. Therefore, we performed a prospective cross-sectional study 219 with T2DM older than 60 years to evaluate the association between fibrosis, steatosis, impairment. Montreal Cognitive Assessment (MoCA) was used screen for MCI or dementia. Liver estimated using non-invasive Fibrosis-4 (FIB-4) score, steatosis assessed hepatic index. mean age 71 ± 6 years, 47% were women according MoCA cut-off values, 53.88% had 16.43% A moderate high advanced significantly higher compared those normal cognition (
Язык: Английский
Процитировано
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