Title: “Labels Matter: Is it stress or is it Trauma?”

Translational Psychiatry, Год журнала: 2021, Номер 11(1)

Опубликована: Июль 10, 2021

Abstract In neuroscience, the term ‘Stress’ has a negative connotation because of its potential to trigger or exacerbate psychopathologies. Yet in face exposure stress, more common reaction stress is resilience, indicating that resilience rule and stress-related pathology exception. This critical neural mechanisms associated with psychopathology are expected differ significantly from those resilience. Research labels terminology affect research directions, conclusions drawn results, way we think about topic, while choice often influenced by biases hidden assumptions. It therefore important adopt differentiates between conditions, leading different outcomes. Here, propose conceptually associate ‘stress’/‘stressful experience’ ‘stress resilience’, restricting use ‘trauma’ only reference exposures lead pathology. We acknowledge there as yet no ideal ways for addressing murkiness border stressful traumatic experiences. ignoring these differences hampers our ability elucidate trauma-related pathologies on one hand, other. Accordingly, discuss how translate such conceptual into practice.

Язык: Английский

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A Baldwin interpretation of adult hippocampal neurogenesis: from functional relevance to physiopathology

Molecular Psychiatry, Год журнала: 2021, Номер 27(1), С. 383 - 402

Опубликована: Июнь 8, 2021

Abstract Hippocampal adult neurogenesis has been associated to many cognitive, emotional, and behavioral functions dysfunctions, its status as a selected effect or an “appendix of the brain” debated. In this review, we propose understand hippocampal process underlying “Baldwin effect”, particular situation in evolution where fitness does not rely on natural selection genetic traits, but “ontogenetic adaptation” changing environment. This supports view that strong distinction between developmental is made. We their are constitution lifelong adaptation, respectively, basic repertoire cognitive emotional behaviors. adaptation occurs through new forms binding, i.e., association dissociation more elements. further suggests difference made vulnerability (or resilience), stemming from dysfunctional highly functional) neurogenesis, neurogenesis. According hypothesis, distinct risk factors for various mental disorders adults. framework avenues research implication disorders.

Язык: Английский

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Sex-divergent long-term effects of single prolonged stress in adult rats

Behavioural Brain Research, Год журнала: 2020, Номер 401, С. 113096 - 113096

Опубликована: Дек. 24, 2020

Язык: Английский

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Translational models of stress and resilience: An applied neuroscience methodology review

Neuroscience Applied, Год журнала: 2024, Номер 3, С. 104064 - 104064

Опубликована: Янв. 1, 2024

Stress, encompassing psychological, physical, and physiological challenges, is an important factor affecting individual's well-being potentially leading to psychiatric, neurodegenerative, immune, metabolic disorders. However, not everyone exposed stress develops these conditions, highlighting the concept of resilience. Resilience a dynamic process categorized into four dimensions: pre-existing resilience capacity, ongoing processes, post-stress outcomes, recovery from psychopathologies. These dimensions involve genomic, cellular, systemic interactions influenced by genetic factors, early life experiences, adult experiences in addition community/environmental health behaviors. The biological response encompasses endocrine, autonomic, immunological, behavioral components, modulated stressor characteristics individual traits. Due limitations studying humans, translational models using rodents cell cultures are essential. Rodent include acute, chronic, traumatic paradigms, aiding study stress-related molecular outcomes. Additionally, models, such as prenatal maternal separation, provide insights developmental impacts. In this review, first, rodent for lifelong exposure will be summarized considering their validity, advantages, limitations. Subsequently, overview designed enhance capacity rodents, later employed outcomes given. Lastly, focus shifted culture iPSCs models. Finally, future considerations focused on improving used discussed. It aimed designs access more effective biomarkers associated with Stress complex phenomena various spanning levels. Integrating data across remains crucial unraveling complexities disorders

Язык: Английский

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A Behavioral Screening Method for Predicting PTSD-like Phenotypes: Novel Application to Female Rats

Journal of Neuroscience Methods, Год журнала: 2025, Номер unknown, С. 110380 - 110380

Опубликована: Янв. 1, 2025

Язык: Английский

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The Utility of Prolonged Chronic Unpredictable Stress to Study the Effects of Chronic Fluoxetine, Eicosapentaenoic Acid, and Lipopolysaccharide on Anxiety‐Like Behavior and Hippocampal Transcriptomic Responses in Male Rats

Journal of Neuroscience Research, Год журнала: 2025, Номер 103(2)

Опубликована: Фев. 1, 2025

Chronic stress is a common trigger of multiple neuropsychiatric illnesses. Animal models are widely used to study stress-induced brain disorders and their interplay with neuroinflammation other neuroimmune processes. Here, we apply the prolonged 12-week chronic unpredictable (PCUS) model examine rat behavioral hippocampal transcriptomic responses 4-week treatment classical antidepressant fluoxetine, an anti-inflammatory agent eicosapentaenoic acid (EPA), pro-inflammatory lipopolysaccharide combinations. Overall, PCUS evoked anxiety-like phenotype in rats, corrected by fluoxetine (alone or combined drugs), EPA. also pronounced hippocampi, involving > 200 differentially expressed genes. While pharmacological manipulations did not affect gene expression markedly, Gpr6, Drd2 Adora2a were downregulated stressed rats treated EPA + EPA, suggesting respective protein products (G protein-coupled receptor 6, dopamine D2 adenosine A2A receptor) as potential evolutionarily conserved targets under stress. these findings support validity paradigm useful stress-related anxiety pathogenesis, call for further research probing how various conventional novel drugs may (co)modulate neurotranscriptomic biomarkers

Язык: Английский

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Social buffering during fear extinction rescues long-term trauma-induced memory and emotional behavioral alterations in rats

Translational Psychiatry, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 21, 2025

Язык: Английский

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Sex differences in fear expression and persistence in an animal model of Post-Traumatic Stress Disorder

Neuroscience, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

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Changes in the Serum Concentration Levels of Serotonin, Tryptophan and Cortisol among Stress-Resilient and Stress-Susceptible Individuals after Experiencing Traumatic Stress

International Journal of Environmental Research and Public Health, Год журнала: 2022, Номер 19(24), С. 16517 - 16517

Опубликована: Дек. 8, 2022

Background: Stress is a common response to many environmental adversities. However, once dysregulated, this reaction can lead psychiatric illnesses, such as post-traumatic stress disorder (PTSD). Individuals develop PTSD after exposure traumatic events, severely affecting their quality of life. Nevertheless, not all individuals exposed will disorders, provided they show enhanced stress-resilience mechanisms that enable them successfully adapt stressful situations and thus avoid developing persistent psychopathology. Methods: The study involved 93 participants. Of them, 62 comprised group 31 control group. aim the was assess serotonin, cortisol tryptophan concentration levels in subjects with (stress-susceptible; PTSD-SS) healthy (stress-resilient; PTSD-SR), who had experienced event but fully recovered trauma. were between 18 50 years age (mean 35.56 ± 8.26 years). serum measured an ELISA kit. Results: It found consistent features both PTSD-SR PTSD-SS patients. reported mean increased more significantly than group, versus those Similarly, larger decrease serotonin No significant changes groups, Conclusions: These findings be useful when attempting improve resilience using neuropharmacological methods. it necessary conduct cross-sectional studies would address different types negative find out whether share pathways.

Язык: Английский

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Prophylactic Efficacy of Riluzole against Anxiety- and Depressive-Like Behaviors in Two Rodent Stress Models

Complex Psychiatry, Год журнала: 2023, Номер 9(1-4), С. 57 - 69

Опубликована: Янв. 1, 2023

Chronic stress-related illnesses such as major depressive disorder and post-traumatic stress share symptomatology, including anxiety, anhedonia, helplessness. Across disorders, neurotoxic dysregulated glutamate (Glu) signaling may underlie symptom emergence. Current first-line antidepressant drugs, which do not directly target Glu signaling, fail to provide adequate benefit for many patients are associated with high relapse rates. Riluzole modulates glutamatergic neurotransmission by increasing metabolic cycling modulating signal transduction. Clinical studies exploring riluzole's efficacy in disorders have provided varied results. However, the utility of riluzole treating specific dimensions or a prophylactic treatment has been comprehensively assessed.We investigated whether chronic (∼12-15 mg/kg/day p.o.) could prevent emergence behavioral deficits induced unpredictable mild (UCMS) mice. We assessed (i) anxiety-like behavior using elevated-plus maze, open-field test, novelty-suppressed feeding, (ii) mixed anxiety/anhedonia-like novelty-induced hypophagia (iii) anhedonia-like sucrose consumption test. Z-scoring summarized changes across tests measuring similar dimensions. In separate learned helplessness (LH) cohort, we block development helplessness-like behavior.UCMS an elevation overall emotionality that was blocked riluzole. LH behavior.This study supports medication preventing anhedonia symptoms disorders.

Язык: Английский

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