A randomized, double-blinded, placebo-controlled clinical trial on Lactobacillus-containing cultured milk drink as adjuvant therapy for depression in irritable bowel syndrome

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Апрель 25, 2024

Irritable bowel syndrome (IBS) is frequently linked with coexisting mental illnesses. Our previous study discovered that 32.1% of IBS patients had subthreshold depression (SD), placing them at higher risk developing major depression. Gut microbiota modulation through psychobiotics was found to influence via the gut-brain axis. However, efficacy lessening among remains ambiguous. The study's aim investigate roles cultured milk drinks containing 10

Язык: Английский

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NEUROBIOLOGICAL ASPECTS OF PATHOGENETIC MECHANISMS IN THE DEVELOPMENT OF POST-TRAUMATIC STRESS DISORDER (LITERATURE REVIEW)

Eastern Ukrainian Medical Journal, Год журнала: 2025, Номер 13(1), С. 39 - 54

Опубликована: Янв. 1, 2025

Post-traumatic stress disorder (PTSD) occurs as a result of exposure to life-threatening traumatic event or situation involving violence. The main manifestations PTSD are obsessive re-experiencing the event, increased nervous arousal, avoidance stimuli related emotional and cognitive disorders that persist for long time. This mental is exhausting causes changes make it difficult sometimes impossible patients with function professionally socially. results in significant clinical burden high socioeconomic costs. Materials methods. authors have reviewed more than 100 scientific papers from world literature on problems diagnosis, symptoms, pathophysiological neurobiological mechanisms play an important role development can be used key elements choice treatment measures. Results. multifactorial disease, therefore, numerous factors involved its occurrence progression. immediate response activation neuroendocrine autonomic systems release adrenaline norepinephrine. involvement hypothalamic-pituitary-adrenal system subsequent secretion cortisol may trigger development. A link has been found between activity noradrenergic system, glucocorticoid exposure, impaired interaction neurons amygdala prefrontal cortex. In addition, glucocorticoids associated immune neuroinflammation. Inflammatory cytokines regulate modify functioning neurotransmitters such serotonin dopamine, which contributes onset progression symptoms. Conclusions. data large number studies allow us confirm following pathogenesis PTSD. These include vegetative regulation, dysfunction immunological regulatory inflammatory mechanisms, dysregulation monoaminergic transmission system. Further study pathogenetic pathways will better implementation strategy medical care

Язык: Английский

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Central Neurobiological Mechanisms of Stress Resistance in Post-Traumatic Stress States

Neuroscience and Behavioral Physiology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 14, 2025

Язык: Английский

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From Cell to Organ: Exploring the Toxicological Correlation of Organophosphorus Compounds in Living System

Toxicology, Год журнала: 2025, Номер unknown, С. 154049 - 154049

Опубликована: Янв. 1, 2025

Язык: Английский

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The neuroscientific basis of post-traumatic stress disorder (PTSD): From brain to treatment

Progress in brain research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Accrued reductions in heart rate following transcutaneous vagal nerve stimulation in adults with posttraumatic stress disorder

Frontiers in Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Март 28, 2025

Post-Traumatic Stress Disorder (PTSD) is a condition marked by chronic autonomic dysregulation, including heightened arousal and increased heart rate, contributing to higher risk of cardiovascular disease (CVD). tcVNS has been shown in prior work decrease reduce rate participants with PTSD during stimulation 2-3 min afterward. No studies have investigated effects on objective physiological markers such as over hour-long timescales. The purpose this study was investigate the active versus sham responses stress traumatized individuals without undergoing 3 h traumatic reminder protocol. Understanding extended periods lasting several hours crucial better assess its potential benefits inform treatment strategies for population. A total 41 participants, 22 (sex: 16 female, six male; age: 41.5 ± 12.89 years) 19 nine 10 32.79 7.10 years), participated mechanistic clinical trial that elicited trauma-incited replaying recorded scripts followed or (double-blind, randomized). Continuous electrocardiogram data were collected used measure temporal alignment resampling beat-by-beat time series performed distinctively enable timepoint averaging entire research visit. We then aggregated across same group (active/sham × PTSD/non-PTSD) multi-hour Analysis revealed accrued reductions among who received compared those (P < 0.05). These not observed non-PTSD participants. Notably, reduced approximately 5% below baseline levels end ∼3 h-long protocol, indicating cardiac function. induces PTSD, potentially suggesting temporary reduction associated PTSD.

Язык: Английский

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Mitochondrial dysfunction as a possible trigger of neuroinflammation at post-traumatic stress disorder (PTSD)

Frontiers in Physiology, Год журнала: 2023, Номер 14

Опубликована: Окт. 24, 2023

Post-traumatic stress disorder (PTSD) is a neuropsychiatric that occurs in approximately 15% of people as result some traumatic events. The main symptoms are re-experiencing and avoidance everything related to this event hyperarousal. component the pathophysiology PTSD an imbalance functioning hypothalamic-pituitary-adrenal axis (HPA) development neuroinflammation. In parallel with this, mitochondrial dysfunction observed, many other diseases. review, we focus on question how mitochondria may be involved neuroinflammation its maintaining at PTSD. First, describe differences operation neuro-endocrine system during versus We then show changes activity/expression proteins they can affect levels hormones development, well damage/pathogen-associated molecule patterns (DAMPs/PAMPs) trigger inflammation. addition, examine possibility treating PTSD-related inflammation using target.

Язык: Английский

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Prominent genetic variants and epigenetic changes in post-traumatic stress disorder among combat veterans

Molecular Biology Reports, Год журнала: 2024, Номер 51(1)

Опубликована: Фев. 23, 2024

Язык: Английский

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Assessing and Modelling of Post-Traumatic Stress Disorder Using Molecular and Functional Biomarkers

Biology, Год журнала: 2023, Номер 12(8), С. 1050 - 1050

Опубликована: Июль 26, 2023

Post-traumatic stress disorder (PTSD) is a complex psychological that develops following exposure to traumatic events. PTSD influenced by catalytic factors such as dysregulated hypothalamic-pituitary-adrenal (HPA) axis, neurotransmitter imbalances, and oxidative stress. Genetic variations may act important catalysts, impacting neurochemical signaling, synaptic plasticity, response systems. Understanding the intricate gene networks their interactions vital for comprehending underlying mechanisms of PTSD. Focusing on essential because they provide valuable insights into disorder. By understanding these interplay, researchers uncover potential targets interventions therapies, leading more effective personalized treatments individuals with The aforementioned networks, composed specific genes associated disorder, comprehensive view molecular pathways regulatory involved in Through this study disorder’s opening avenues treatments, interventions, development biomarkers early detection monitoring are provided.

Язык: Английский

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Probing the oral-brain connection: oral microbiome patterns in a large community cohort with anxiety, depression, and trauma symptoms, and periodontal outcomes

Translational Psychiatry, Год журнала: 2024, Номер 14(1)

Опубликована: Окт. 5, 2024

The role of the oral microbiome in mental health has recently been appreciated within proposed oral-brain axis. This study examined structure and composition salivary a large-scale population-based cohort individuals reporting symptoms (n = 306) compared to mentally healthy controls 164) using 16S rRNA sequencing. Mental were evaluated validated questionnaires included depression, anxiety, posttraumatic stress disorder (PTSD), with accompanying periodontal outcomes. Participants also indicated current or previous diagnoses periodontitis, gingivitis. variables influenced overall microbiome. PTSD correlated lower clr-transformed relative abundance Haemophilus sputorum higher Prevotella histicola. P. histicola was positively associated depressive scores negatively psychological quality life. Anxiety diagnosis Neisseria elongate Oribacterium asaccharolyticum. A Shuttleworthia Capnocytophaga evident those who reported clinical periodontitis diagnosis. Higher Eggerthia parainfluenzae abundances psychotherapeutic efficacy. Functional prediction analysis revealed potential for tryptophan metabolism/degradation axis, which confirmed by plasma serotonin levels across symptomatic groups. sheds light on intricate interplay between microbiota, outcomes, metabolism emphasizing need further exploration pave way novel therapeutic interventions predicting response.

Язык: Английский

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