Journal of Personalized Medicine,
Год журнала:
2022,
Номер
12(10), С. 1634 - 1634
Опубликована: Окт. 2, 2022
Previous
studies
have
explored
the
role
of
microbiome
in
attention-deficit/hyperactivity
disorder
(ADHD).
However,
whether
is
correlated
with
emotional-behavioral
disturbances,
most
common
comorbid
symptom
ADHD,
remains
unclear.
We
established
a
cross-sectional
study
which
6-
to
18-year-old
children
ADHD
who
were
receiving
no
medication
and
healthy
control
group
without
recruited
analyze
their
composition.
Microbiota
fecal
samples
collected
analyzed
using
16s
rRNA
gene
sequencing
approach.
In
comparison
group,
gut
microbiota
exhibited
significantly
lower
beta
diversity.
The
abundance
phylum
Proteobacteria
genera
Agathobacter,
Phascolarctobacterium,
Prevotella_2,
Acidaminococcus,
Roseburia,
Ruminococcus
gnavus
was
increased
compared
group.
Linear
discriminant
effect
size
(LEfSe)
analysis
used
highlight
specific
bacteria
phylotypes
that
differentially
altered
between
groups.
A
regression
performed
investigate
association
symptoms
ADHD.
significant
noted
withdrawal
depression
Agathobacter
(p
=
0.044),
rule-breaking
behavior
0.046)
after
adjusting
for
sex,
age,
core
score.
This
advances
knowledge
how
composition
may
contribute
detailed
mechanisms
underlying
pathophysiology
still
require
further
investigation.
Nutrients,
Год журнала:
2023,
Номер
15(14), С. 3258 - 3258
Опубликована: Июль 23, 2023
The
number
of
individuals
experiencing
mental
disorders
(e.g.,
anxiety
and
depression)
has
significantly
risen
in
recent
years.
Therefore,
it
is
essential
to
seek
prevention
treatment
strategies
for
disorders.
Several
gut
microbiota,
especially
Firmicutes
Bacteroidetes,
are
demonstrated
affect
health
through
microbiota-gut-brain
axis,
the
microbiota
dysbiosis
can
be
related
disorders,
such
as
anxiety,
depression,
other
On
hand,
dietary
components,
including
probiotics
Lactobacillus
Bifidobacterium),
prebiotics
fiber
alpha-lactalbumin),
synbiotics,
postbiotics
short-chain
fatty
acids),
dairy
products,
spices
Zanthoxylum
bungeanum,
curcumin,
capsaicin),
fruits,
vegetables,
medicinal
herbs,
so
on,
could
exert
protective
effects
against
by
enhancing
beneficial
while
suppressing
harmful
ones.
In
this
paper,
disorder-associated
summarized.
addition,
components
on
targeting
discussed.
This
paper
helpful
develop
some
natural
products
into
pharmaceuticals
functional
foods
prevent
treat
Abstract
Previous
studies
have
shown
a
bidirectional
communication
between
human
gut
microbiota
and
the
brain,
known
as
microbiota–gut–brain
axis
(MGBA).
The
MGBA
influences
host's
nervous
system
development,
emotional
regulation,
cognitive
function
through
neurotransmitters,
immune
modulation,
metabolic
pathways.
Factors
like
diet,
lifestyle,
genetics,
environment
shape
composition
together.
Most
research
explored
how
regulates
host
physiology
its
potential
in
preventing
treating
neurological
disorders.
However,
individual
heterogeneity
of
microbiota,
strains
playing
dominant
role
diseases,
interactions
these
microbial
metabolites
with
central/peripheral
systems
still
need
exploration.
This
review
summarizes
driving
neurodevelopmental
disorders
(autism
spectrum
disorder
attention
deficit/hyperactivity
disorder),
neurodegenerative
diseases
(Alzheimer's
Parkinson's
disease),
mood
(anxiety
depression)
recent
years
discusses
current
clinical
preclinical
microbe‐based
interventions,
including
dietary
intervention,
probiotics,
prebiotics,
fecal
transplantation.
It
also
puts
forward
insufficient
on
provides
framework
for
further
Children,
Год журнала:
2024,
Номер
11(7), С. 796 - 796
Опубликована: Июнь 28, 2024
The
formation
of
the
human
gut
microbiome
initiates
in
utero,
and
its
maturation
is
established
during
first
2–3
years
life.
Numerous
factors
alter
composition
functions,
including
mode
delivery,
early
onset
breastfeeding,
exposure
to
antibiotics
chemicals,
maternal
stress,
among
others.
microbiome–brain
axis
refers
interconnection
biological
networks
that
allow
bidirectional
communication
between
brain,
involving
nervous,
endocrine,
immune
systems.
Evidence
suggests
metabolic
byproducts
are
actively
implicated
regulation
brain
development.
Any
disturbance
this
stage
may
adversely
affect
resulting
a
variety
neurodevelopmental
disorders
(NDDs).
In
present
study,
we
reviewed
recent
evidence
regarding
impact
on
development,
alongside
correlation
with
significant
NDDs,
such
as
autism
spectrum
disorder,
attention-deficit/hyperactivity
Tourette
syndrome,
cerebral
palsy,
fetal
alcohol
disorders,
genetic
NDDs
(Rett,
Down,
Angelman,
Turner
syndromes).
Understanding
changes
provide
new
chances
for
their
treatment
future.
Nutrients,
Год журнала:
2024,
Номер
16(14), С. 2260 - 2260
Опубликована: Июль 13, 2024
We
conducted
a
12-week
randomized
double-blind
placebo-controlled
clinical
trial
to
investigate
the
potential
impact
of
Bifidobacterium
bifidum
(Bf-688)
supplementation
on
attention-deficit/hyperactivity
disorder
(ADHD).
Children
with
ADHD
who
were
already
receiving
stable
dose
methylphenidate
(MPH)
treatment
enrolled
and
randomly
assigned
two
groups:
one
add-on
Bf-688
(daily
bacterial
count
5
×
109
CFUs)
(n
=
51)
other
placebo
51).
All
participants
underwent
assessments
using
Conners’
Continuous
Performance
Test
(CPT)
Auditory
Attention
(CATA).
Additionally,
fecal
samples
collected
at
beginning
(week
0)
endpoint
12).
Remarkably,
group
supplementation,
but
not
group,
exhibited
significant
improvements
in
omission
errors
CPT
as
well
Hit
reaction
time
both
CATA.
Gut
microbiome
analysis
revealed
increase
Firmicutes
Bacteroidetes
ratio
(F/B
ratio)
only
group.
Furthermore,
we
identified
negative
correlations
between
N-Glycan
biosynthesis
Our
results
demonstrate
that
probiotic
supplement
can
enhance
neuropsychological
performance
children
ADHD,
possibly
by
altering
composition
gut
microbiota,
ultimately
leading
reduced
biosynthesis.
Microorganisms,
Год журнала:
2022,
Номер
10(10), С. 2009 - 2009
Опубликована: Окт. 11, 2022
The
aim
of
our
work
is
to
summarize
the
current
state
knowledge
on
gut
microbiota
differences
in
children
and
adolescents
with
psychiatric
disorders.
To
find
relevant
articles,
PubMed,
Web
Science,
Google
Scholar
databases
were
searched.
Articles
English
presenting
original
data
comparing
composition
child
patients
healthy
selected.
Finally,
we
identified
55
articles
eligible
for
purpose.
majority
autism
spectrum
disorders
(ASD)
investigated.
A
smaller
number
studies
evaluating
attention-deficit/hyperactivity
disorder
(ADHD),
Rett
syndrome,
anorexia
nervosa,
depressive
(DD),
tic
found.
main
findings
this
research
are
discussed
review,
focusing
age-related
specificity
between
individual
diagnosis.
conclude,
evidently
different
from
that
controls.
most
pronounced
seen
ASD,
less
ADHD.
Moreover,
changes
not
identical
those
adult
patients,
as
Ruminococcus,
Turicibacter,
Bilophila
increased
adults,
decreased
Parabacteroides
Alistipes
more
frequently
represented
but
depression.
available
suggest
some
genera
have
a
abundance
(e.g.,
Bilophila,
Bifidobacterium,
Clostridium,
Coprococcus,
Faecalibacterium,
Ruminococcus),
suggesting
their
importance
gut–brain
axis.
Other
bacterial
might
be
important
pathophysiology
specific
adolescents,
Akkermansia
Desulfovibrio
or
Romboutsia
DD.
Based
findings,
assume
corrections
potential
improve
clinical
symptoms
patients.
Journal of Child Psychology and Psychiatry,
Год журнала:
2023,
Номер
64(9), С. 1280 - 1291
Опубликована: Апрель 5, 2023
Background
Dysbiosis
in
the
gut
microbial
community
might
be
involved
pathophysiology
of
attention‐deficit/hyperactivity
disorder
(ADHD).
The
fungal
component
microbiome,
namely
mycobiota,
is
a
hyperdiverse
group
multicellular
eukaryotes
that
can
influence
host
intestinal
permeability.
This
study
therefore
aimed
to
investigate
impact
mycobiome
dysbiosis
and
permeability
on
ADHD.
Methods
Faecal
samples
were
collected
from
35
children
with
ADHD
healthy
controls.
Total
DNA
was
extracted
faecal
internal
transcribed
spacer
regions
sequenced
using
high‐throughput
next‐generation
sequencing
(NGS).
taxonomic
classification
analysed
bioinformatics
tools
differentially
expressed
species
between
control
groups
identified.
An
vitro
assay
(Caco‐2
cell
layer)
used
evaluate
biological
effects
epithelial
barrier
function.
Results
β‐diversity
(the
diversity
two
communities
),
but
not
α‐diversity
within
community),
reflected
differences
composition
groups.
At
phylum
level,
displayed
significantly
higher
abundance
Ascomycota
lower
Basidiomycota
than
group.
genus
Candida
(especially
albicans
)
increased
patients
compared
In
addition,
revealed
C.
secretions
enhanced
Caco‐2
cells.
Conclusions
current
first
explore
altered
NGS
platform
findings
this
indicated
associated
susceptibility
Journal of Attention Disorders,
Год журнала:
2023,
Номер
27(8), С. 880 - 886
Опубликована: Март 6, 2023
This
study
aims
that
oxidative
stress
and
inflammation
status
in
children
adolescents
with
attention
deficit
hyperactivity
disorder
(ADHD)
compared
to
their
healthy
peers.Thirty
ADHD
controls
were
included
this
study.
diagnosis
according
the
DSM-V
Conners'
teacher
parent
rating
scale
by
a
structured
psychiatric
interview.
Total
oxidant
(TOS),
total
antioxidant
(TAS),
native
thiol
levels
determined
using
photometric
methods.
Presepsin,
Interleukin
(IL)
1-ß,
IL-6,
Tumor
Necrosis
Factor-alpha
(TNF-α)
measured
commercial
ELISA
kits.We
showed
TOS
index
significantly
higher
group,
TAS
was
lower
than
control
group
(p<.001).
Similarly,
IL1-ß,
TNF-α
statistically
group.
Backward
LR
regression
analysis
reveals
IL-6
predicted
ADHD.TOS
may
play
role
pathogenesis
of
ADHD.
The Kaohsiung Journal of Medical Sciences,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
Attention-deficit/hyperactivity
disorder
(ADHD)
is
a
common
psychiatric
condition
among
children
and
adolescents,
often
associated
with
high
risk
of
comorbidities.
Currently,
ADHD
diagnosis
relies
exclusively
on
clinical
presentation
patient
history,
underscoring
the
need
for
clinically
relevant,
reliable,
objective
biomarkers.
Such
biomarkers
may
enable
earlier
lead
to
improved
treatment
outcomes.
Our
research
team
has
focused
identifying
potential
by
investigating
its
possible
pathomechanisms,
consideration
aforementioned
criteria.
Given
significant
sex-related
differences
in
prevalence
(male
predominance)
age-related
variability
symptomatology,
we
explored
role
neuroendocrine
systems
ADHD.
Specifically,
examined
epigenetic
regulation
mechanism
involved
pathogenesis
developed
diagnostic
model
based
peripheral
microRNA.
Additionally,
investigated
microbiota
dysbiosis
pathophysiology
provided
novel
insights
into
management.
This
paper
presents
summary
our
findings
By
analyzing
blood,
salivary,
fecal
samples,
identified
several
promising
that
serve
as
parameters
improving
accuracy
Further
involving
larger
cohort
studies
required
confirm
reliability
these
