Toxics,
Год журнала:
2024,
Номер
12(12), С. 918 - 918
Опубликована: Дек. 19, 2024
Brominated
flame
retardants
(BFRs)
are
a
type
of
widespread
pollutant
that
can
be
transmitted
through
particulate
matter,
such
as
dust
in
the
air,
and
have
been
associated
with
various
adverse
health
effects,
diabetes,
metabolic
syndrome,
cardiovascular
disease.
However,
there
is
limited
research
on
link
between
exposure
to
mixtures
BFRs
depression
general
population.
To
analyze
association
population,
nationally
representative
data
from
National
Health
Nutrition
Examination
Survey
(NHANES;
2005-2016)
were
used.
In
final
analysis,
total
8138
adults
aged
20
years
older
included.
investigate
potential
relationship
outcomes,
we
used
binary
logistic
regression,
restricted
cubic
spline
(RCS),
quantile-based
g
computation
(QGC),
weighted
quantile
sum
(WQS)
regression.
The
findings
showed
serum
BFR
concentrations
depressive
symptoms
over
broad
spectrum.
Binary
regression
RCS
analysis
certain
BFRs,
particularly
PBB153,
significantly
positively
incidence
depression,
even
after
adjustment
for
confounders
(p
<
0.05).
Mixed
was
also
found
stronger
men.
two
most
influential
PBB153
PBDE85,
identified
both
mixed
models
risk
factors
concern.
Our
study
new
insights
into
but
sizable
population-based
cohort
studies
toxicology
mechanism
will
needed
establish
causality.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(36), С. 19838 - 19851
Опубликована: Авг. 26, 2024
Depression
is
a
widespread
disease,
with
high
mortality
and
recurrence
rates.
Recent
studies
have
shown
that
elevated
cytokine
levels
are
implicated
in
the
molecular
mechanisms
of
depression.
Oxidative
stress
contributes
to
stimulation
production.
Growing
evidence
suggests
ginsenoside
Re
(Gs-Re)
exerts
neuroprotective
effect
on
hippocampus
by
suppressing
oxidative
inflammation.
However,
mechanism
Gs-Re
treatment
depression
remain
understudied.
This
study
aimed
evaluate
antidepressant-like
effects
possible
underlying
mechanisms.
In
this
article,
was
studied
both
vitro
(H
PLoS ONE,
Год журнала:
2025,
Номер
20(2), С. e0311207 - e0311207
Опубликована: Фев. 10, 2025
Saikosaponin
A
(SSA),
a
key
ingredient
of
Chaihu-Shugan-San,
has
been
shown
to
possess
anti-inflammatory,
antioxidant
and
antidepressant
properties.
Therefore,
the
present
study
aimed
investigate
potential
mechanism
action
effect
SSA
on
reserpine-induced
depressive-like
symptoms
in
mice.
Establishing
mouse
model
depression
using
intraperitoneal
injection
reserpine
(RSP).
Forced
swimming
test,
tail
suspension
test
sucrose
preference
were
used
assess
depression-like
behavior
The
results
showed
that
mice
exposed
RSP
not
only
weight
loss
depressive
behavior,
but
also
elevated
levels
IL-1β
TNF-α,
as
well
upregulated
reactive
oxygen
species
(ROS)
lipid
peroxides
hippocampus.
Detection
changes
intestinal
flora
16S
rRNA,
it
was
observed
changed
following
treatment.
Not
there
an
increase
overall
abundance
microbiota,
significant
down-regulation
Firmicutes
up-regulation
Verrucomicrobia
at
phylum
level.
Furthermore,
treatment
markedly
improved
induced
by
RSP,
alleviated
damage
hippocampus,
monoamine
neurotransmitters,
suppressed
inflammatory
factors
reduced
hippocampal
oxidative
stress,
restored
gut
microbiota
disruption
RSP-induced
findings
propose
alleviate
enhancing
neurotransmitter
levels,
suppressing
inflammation,
modifying
microbial
composition.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 21, 2025
Previously,
abobotulinumtoxinA
(aboBoNT-A)
injected
intraoperatively
resulted
in
effective,
but
delayed
post-surgical
analgesia
pigs.
Here,
we
explore
the
efficacy
of
preemptively
administered
aboBoNT-A
intact
animals
on
pain
and
associated
behaviors
following
a
full-skin-muscle
incision
retraction
surgery
lower
back.
AboBoNT-A
(200
U/animal)
or
saline,
distributed
across
ten
points,
were
around
anticipated
15,
5,
1
day
before
via
ID
route
(part
A)
15
days
ID,
intramuscular
(IM)
subcutaneous
(SC)
routes
B).
We
assessed
mechanical
sensitivity
(withdrawal
force;
WF),
distress
behavior
score
(DBS),
latency
to
approach
investigator
after
for
7
days.AboBoNT-A,
surgery,
didn't
alter
any
baseline
behaviors,
5-fold
increases
WF,
75%
reduction
DBS
70%
latencies
(all
p
<
0.01).
Injections
5
led
similar
effects,
albeit
with
fewer
reaching
thresholds,
while
those
made
less
effective.
SC
IM
injections
ineffective.
Thus,
represents
most
optimal
condition
postoperative
analgesia.
These
findings
warrant
clinical
investigation
postsurgical
pain.
Inflammopharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 27, 2025
Quercetin
is
a
flavonoid
commonly
found
in
various
fruits,
vegetables,
and
grains.
Studies
have
demonstrated
that
quercetin
may
help
protect
neuronal
cells
from
damage
caused
by
neurotoxins
associated
with
Parkinson's
disease,
however,
the
underlying
mechanism
remains
unclear.
The
current
study
aimed
to
investigate
neuroprotective
effects
of
MPTP-induced
disease
mouse
models
elucidate
its
mechanistic
role
modulating
PI3K/Akt/GSK-3β
signaling
pathway.
Male
C57BL/6
mice
were
divided
into
control,
MPTP,
quercetin,
MPTP
+
groups.
protective
on
evaluated
using
animal
behaviour
analysis,
histopathological
examination,
immunofluorescence
staining.
Subsequently,
network
pharmacology
was
utilized
determine
primary
target
sites
disease.
Finally,
western
blotting
molecular
docking
techniques
applied
validate
identified
targets.
significantly
improved
motor
deficits
mice,
reduced
atrophy,
preserved
TH+
dopaminergic
neurons.
Western
analysis
revealed
upregulated
anti-inflammatory
IL-10
(p
<
0.01)
TGF-β
while
suppressing
pro-inflammatory
IL-1β
iNOS
0.01).
It
activated
pathway
increasing
phosphorylation
PI3K
0.01),
Akt
GSK-3β
also
elevated
anti-apoptotic
Bcl-2
pro-apoptotic
Bax
Caspase-9
Molecular
confirmed
strong
binding
between
(binding
energies:
-6.44
-5.24
kcal/mol).
alleviates
pathology
inhibiting
neuroinflammation,
reducing
apoptosis,
activating
These
findings
underscore
potential
as
multi-target
therapeutic
agent
for
Pharmacological Research,
Год журнала:
2025,
Номер
unknown, С. 107717 - 107717
Опубликована: Март 1, 2025
Anxiety
and
depression
are
common
non-motor
symptoms
of
Parkinson's
disease
(PD)
that
significantly
affect
patients'
quality
life.
In
recent
years,
our
understanding
PD
has
advanced
through
multifaceted
studies
on
the
pathological
mechanisms
associated
with
anxiety
in
PD.
These
classic
psychiatric
involve
complex
pathophysiology,
both
distinct
features
connections
to
underlying
aetiology
Furthermore,
co-occurrence
blurs
boundaries
between
them.
Therefore,
a
comprehensive
summary
pathogenic
will
aid
better
addressing
emergence
these
This
article
integrates
neuroanatomical,
neural
projection,
neurotransmitter,
neuroinflammatory,
brain-gut
axis,
neurotrophic,
hypothalamic-pituitary-adrenal
genetic
perspectives
provide
description
core
alterations
PD,
aiming
an
up-to-date
perspective
broader
therapeutic
prospects
for
patients
suffering
from
or
depression.
The Korean journal of pain,
Год журнала:
2024,
Номер
37(2), С. 91 - 106
Опубликована: Март 4, 2024
The
mechanisms
of
the
chronic
pain
and
depression
comorbidity
have
gained
significant
attention
in
recent
years.The
complement
system,
widely
involved
central
nervous
system
diseases
mediating
non-specific
immune
body,
remains
incompletely
understood
its
involvement
depression.This
review
aims
to
consolidate
findings
from
studies
on
depression,
proposing
that
it
may
serve
as
a
promising
shared
therapeutic
target
for
both
conditions.Complement
proteins
C1q,
C3,
C5,
well
their
cleavage
products
C3a
C5a,
along
with
associated
receptors
C3aR,
CR3,
C5aR,
are
believed
implications
comorbid
mechanism.The
primary
potential
encompass
cascade
C1q/C3-CR3
activation
microglia
synaptic
pruning
amygdala
hippocampus,
role
C3/C3a-C3aR
interaction
between
astrocytes
microglia,
leading
pruning,
C3a-C3aR
axis
C5a-C5aR
trigger
inflammation
within
system.We
focus
depression.
