PREDICTION OF INTERSTITIAL LUNG DISEASE PROGRESSION IN SYSTEMIC SCLEROSIS PATIENTS: A COHORT STUDY ANALYSIS

The Bulletin of Contemporary Clinical Medicine, Год журнала: 2024, Номер 17(2), С. 79 - 84

Опубликована: Апрель 1, 2024

Introduction. Systemic sclerosis (scleroderma) is an autoimmune disease that often causes inflammatory fibrosing lesions of the pulmonary interstitial tissue, referred to as lung disease. It associated with a significant reduction in survival and leading immediate cause systemic scleroderma patients’ death. Progression rate varies greatly. Since specific immunosuppressive antifibrotic treatment only justified case progressive lesions, predicting progression great practical importance. Aim: To develop approaches patients. Materials Methods. Our analysis included data patients observed Registry Myositis, Scleroderma Mixed Diseases (REMISSiZ). Inclusion criteria: Age 18+ years, proven scleroderma, eligibility for ACR/EULAR (2013), repeated high-resolution computed tomography lungs interval at least 1 year. All underwent 6-minute walking tests. Results Discussion. The study 44 (43 women) aged 62.9 ± 11.5 years average. average follow-up duration was 530 231 days. Radiological younger age, p=0.03, severity Raynaud’s phenomenon, p=0.032, shorter duration, p=0.038, distance covered walk test, p=0.05. functional impairment, determined by dynamics decrease blood oxygen saturation rest (p=0.003), breath shortness according Borg scale (p=0.006), initial test (p <0.001), presence topoisomerase I antibodies (anti-Scl-70, p=0.034), complaints (p=0.043) dysphagia (p=0.034). As result reverse stepwise selection variables, three independent predictors were selected from above indicators: Dysphagia, anti-Scl-70, test. Based on these indicators, regression formula presented impairment Conclusions. X-ray-detected age phenomenon severity. predict decline functionality, it advisable consider (anti-Scl-70).

Язык: Английский

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HIV- AND TUBERCULOSIS-ASSOCIATED PERICARDITIS

The Bulletin of Contemporary Clinical Medicine, Год журнала: 2024, Номер 17(2), С. 91 - 97

Опубликована: Апрель 1, 2024

Introduction. HIV infection, despite the measures taken, continues to spread throughout world. Unfavorable course of diseases is often determined by some concomitant pathologies. Among HIV-infected patients, tuberculosis most common disease forming comorbid condition named “TB/HIV” that reaches more than a half all cases newly diagnosed in regions Russia. In recent years, due increase HIV- infected patients’ life expectancy based on antiretroviral therapy, cardiovascular diseases, such as primarily infectious pericarditis, are gradually beginning hold significant place. Aim: To select and analyze publications dealing with tuberculosis-associated pericarditis. Materials Methods. A systematic search was conducted for examined possible associations between pericardial damage, infection tuberculosis. carried out electronic databases PubMed, www.pubmed.gov; MEDLINE, www.ncbi. nlm.nih.gov; Russian scientific database eLibrary, https://www.elibrary.ru. Preference given meta-analyses or reviews, studies duplicate materials were excluded from analysis. Results Discussion. Publications epidemiology pericarditis associated world Russia presented authors different countries; both human immunodeficiency virus mycobacterium important development Tuberculous being rare manifestation tuberculosis, usually reflects severity an unfavorable prognosis. unexplained effusion, it advisable include testing differential diagnosis plan. Conclusions. Diagnosis requires multidisciplinary approach; late has

Язык: Английский

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Targeting novel regulated cell death：Ferroptosis, pyroptosis, and autophagy in sepsis-associated encephalopathy

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 174, С. 116453 - 116453

Опубликована: Март 20, 2024

Sepsis-associated encephalopathy (SAE), a common neurological complication of sepsis, is heterogenous complex clinical syndrome caused by the dysfunctional response host to infection. This leads excess mortality and morbidity worldwide. Despite relevance with high incidence, there lack understanding for its both acute/chronic pathogenesis therapeutic management. A better molecular mechanisms behind SAE may provide tools enhance efficacy. Mounting evidence indicates that some types non-apoptotic regulated cell death (RCD), such as ferroptosis, pyroptosis, autophagy, contribute SAE. Targeting these RCD meaningful targets future treatments against review summarizes core mechanism which We focus on emerging compounds can inhibit delineate their beneficial pharmacological effects Within this we suggest inhibition serve potential strategy

Язык: Английский

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Regulated Cell Death in Endometriosis

Biomolecules, Год журнала: 2024, Номер 14(2), С. 142 - 142

Опубликована: Янв. 23, 2024

Regulated cell death (RCD) represents a distinct mode of demise, differing from accidental (ACD), characterized by specific signaling cascades orchestrated diverse biomolecules. The regular process plays crucial role in upholding internal homeostasis, acting as safeguard against biological or chemical damage. Nonetheless, programmed deaths have the potential to activate an immune–inflammatory response, potentially contributing diseases enlisting immune cells and releasing pro-inflammatory factors. Endometriosis, prevalent gynecological ailment, remains incompletely understood despite substantial progress unraveling associated pathways. Its complexity is intricately tied dysregulation inflammatory responses, with various RCD processes such apoptosis, autophagic death, pyroptosis, ferroptosis implicated its development. Notably, limited research explores association between endometriosis pathways like pyroptosis cuproptosis. exploration regulated context holds tremendous for further advancements. This article thoroughly reviews molecular mechanisms governed their implications endometriosis. A comprehensive understanding mechanism has catalyze development promising therapeutic strategies chart course future directions field.

Язык: Английский

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Maresin1 improves hippocampal neuroinflammation and cognitive function in septic rats by activating the SLC7A11 / GPX4 ferroptosis signaling pathway

International Immunopharmacology, Год журнала: 2024, Номер 131, С. 111792 - 111792

Опубликована: Март 13, 2024

Sepsis-associated encephalopathy (SAE) is a prevalent complication of sepsis, with hippocampal neuroinflammation playing crucial role in SAE-induced cognitive impairment. Maresin1 (MaR1), bioactive docosahexaenoic acid (DHA) metabolite, demonstrates comprehensive anti-inflammatory and neuroprotective attributes. Yet, its protective efficacy against decline remains unexplored. In this investigation, we implemented rat SAE model via cecal ligation puncture (CLP), while lipopolysaccharide (LPS) stimulation HT22 cells simulated an vitro model; both models were pre-treated MaR1. We evaluated learning memory using water maze, assessed neuron damage Nissl FJC staining, observed mitochondrial alterations through TEM. vivo assays gauged levels Fe

Язык: Английский

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The mechanism and therapeutic strategies in Doxorubicin induced cardiotoxicity: Role of programmed cell death

Cell Stress and Chaperones, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

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PANoptosis: a novel target for cardiovascular diseases

Trends in Pharmacological Sciences, Год журнала: 2024, Номер 45(8), С. 739 - 756

Опубликована: Авг. 1, 2024

Язык: Английский

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What is the impact of ferroptosis on diabetic cardiomyopathy: a systematic review

Heart Failure Reviews, Год журнала: 2023, Номер 29(1), С. 1 - 11

Опубликована: Авг. 9, 2023

Язык: Английский

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Baicalin Attenuates Diabetic Cardiomyopathy In Vivo and In Vitro by Inhibiting Autophagy and Cell Death Through SENP1/SIRT3 Signaling Pathway Activation

Antioxidants and Redox Signaling, Год журнала: 2024, Номер unknown

Опубликована: Апрель 30, 2024

Diabetic heart damage can lead to cardiomyocyte death, which endangers human health. Baicalin (BAI) is a bioactive compound that plays an important role in cardiovascular diseases. Sentrin/SUMO-specific protease 1 (

Язык: Английский

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Astragaloside IV alleviates septic myocardial injury through DUSP1-Prohibitin 2 mediated mitochondrial quality control and ER-autophagy

Journal of Advanced Research, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Septic cardiomyopathy (SCM) is a complication of myocardial injury in patients with severe sepsis. This study highlights the potential Astragaloside IV(AS) treatment septic and provides reference for developing cardioprotective drugs targeting DUSP1-PHB2-related mitochondria-ER interaction. Dual specificity phosphatase-1 (DUSP1)/Prohibitin 2 cardiomyocyte-specific knockout mice (DUSP1/PHB2CKO) /DUSP1 transgenic (DUSP1/PHB2TG) were used to generate LPS-induced sepsis models. The pathological mechanism by which AS-IV improves heart was detected using cardiac ultrasound, fluorescence staining, transmission electron microscopy, western blotting. After siRNA cardiomyocytes DUSP-1/PHB2, changes mitochondrial function morphology determined qPCR, blotting, ELISA, laser confocal targeted therapeutic effects further examined. SCM leads dysfunction. However, IV (AS) normalizes homeostasis ER function. Notably, protective effect blocked DUSP1/Prohibitin but remained unaffected DUSP1 (DUSP1/PHB2TG). AS DUSP1-PHB2 related

Язык: Английский

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